{"id":51386,"date":"2024-12-17T15:31:11","date_gmt":"2024-12-17T15:31:11","guid":{"rendered":""},"modified":"2024-12-17T15:31:11","modified_gmt":"2024-12-17T15:31:11","slug":"%d8%aa%d8%b1%d8%ac%d9%85%d9%87-%d9%81%d8%a7%d8%b1%d8%b3%db%8c-%d9%85%d9%82%d8%a7%d9%84%d9%87-51386","status":"publish","type":"product","link":"https:\/\/express24.ir\/d\/product\/%d8%aa%d8%b1%d8%ac%d9%85%d9%87-%d9%81%d8%a7%d8%b1%d8%b3%db%8c-%d9%85%d9%82%d8%a7%d9%84%d9%87-51386\/","title":{"rendered":"\u062a\u0631\u062c\u0645\u0647 \u0641\u0627\u0631\u0633\u06cc \u0645\u0642\u0627\u0644\u0647 \u0648\u0627\u06a9\u0646\u0634 \u0632\u0627\u06cc\u06cc \u0648 \u0627\u06cc\u0645\u0646\u06cc \u0632\u0627\u06cc\u06cc \u062f\u0631 \u0628\u0631\u0627\u0628\u0631 MPXV \u062a\u0632\u0631\u06cc\u0642 \u062f\u0627\u062e\u0644 \u062c\u0644\u062f\u06cc Vaccinia Ankara \u0627\u0635\u0644\u0627\u062d \u0634\u062f\u0647 \u062f\u0631 \u0645\u0642\u0627\u06cc\u0633\u0647 \u0628\u0627 \u0645\u0633\u06cc\u0631 \u0632\u06cc\u0631 \u062c\u0644\u062f\u06cc \u0627\u0633\u062a\u0627\u0646\u062f\u0627\u0631\u062f"},"content":{"rendered":"\n\n\n\n\n\n\n\n\n\n\n\n
\u0639\u0646\u0648\u0627\u0646 \u0645\u0642\u0627\u0644\u0647 \u0628\u0647 \u0627\u0646\u06af\u0644\u06cc\u0633\u06cc <\/td>\nReactogenicity and immunogenicity against MPXV of the intradermal administration of Modified Vaccinia Ankara compared to the standard subcutaneous route<\/td>\n<\/tr>\n
\u0639\u0646\u0648\u0627\u0646 \u0645\u0642\u0627\u0644\u0647 \u0628\u0647 \u0641\u0627\u0631\u0633\u06cc <\/td>\n\u062a\u0631\u062c\u0645\u0647 \u0641\u0627\u0631\u0633\u06cc \u0645\u0642\u0627\u0644\u0647 \u0648\u0627\u06a9\u0646\u0634 \u0632\u0627\u06cc\u06cc \u0648 \u0627\u06cc\u0645\u0646\u06cc \u0632\u0627\u06cc\u06cc \u062f\u0631 \u0628\u0631\u0627\u0628\u0631 MPXV \u062a\u0632\u0631\u06cc\u0642 \u062f\u0627\u062e\u0644 \u062c\u0644\u062f\u06cc Vaccinia Ankara \u0627\u0635\u0644\u0627\u062d \u0634\u062f\u0647 \u062f\u0631 \u0645\u0642\u0627\u06cc\u0633\u0647 \u0628\u0627 \u0645\u0633\u06cc\u0631 \u0632\u06cc\u0631 \u062c\u0644\u062f\u06cc \u0627\u0633\u062a\u0627\u0646\u062f\u0627\u0631\u062f<\/td>\n<\/tr>\n
\u0646\u0648\u06cc\u0633\u0646\u062f\u06af\u0627\u0646 <\/td>\n ProfileValentina Mazzotta, ProfilePierluca Piselli, ProfileAlessandro Cozzi Lepri, ProfileGiulia Matusali, ProfileEleonora Cimini, ProfileRozenn Esvan, ProfileFrancesca Colavita, ProfileRoberta Gagliardini, ProfileStefania Notari, Alessandra Oliva, ProfileSilvia Meschi, ProfileRita Casetti, Giulia Micheli, ProfileLicia Bordi, Alessandro Giacinta, ProfileGermana Grassi, ProfileSaba Gebremeskel Tekle, ProfileClaudia Cimaglia, ProfileJessica Paulicelli, ProfileAlessandro Caioli, Paola Gall\u00ec, Giulia Del Duca, ProfileMiriam Lichtner, ProfileLoredana Sarmati, ProfileEnrica Tamburrini, ProfileClaudio Mastroianni, ProfileAlessandra Latini, Paolo Faccendini, ProfileCarla Fontana, ProfileEmauele Nicastri, ProfileAndrea Siddu, ProfileAlessandra Barca, Francesco Vaia, ProfileEnrico Girardi, ProfileFabrizio Maggi, ProfileAndrea Antinori, MPOX Vaccine Lazio Study Group<\/td>\n<\/tr>\n
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\u062a\u0639\u062f\u0627\u062f \u0635\u0641\u062d\u0627\u062a<\/td>\n31<\/td>\n<\/tr>\n
\u0644\u06cc\u0646\u06a9 \u062f\u0627\u0646\u0644\u0648\u062f \u0631\u0627\u06cc\u06af\u0627\u0646 \u0645\u0642\u0627\u0644\u0647 \u0627\u0646\u06af\u0644\u06cc\u0633\u06cc<\/td>\n\u062f\u0627\u0646\u0644\u0648\u062f \u0645\u0642\u0627\u0644\u0647<\/a><\/td>\n<\/tr>\n
\u062f\u0633\u062a\u0647 \u0628\u0646\u062f\u06cc \u0645\u0648\u0636\u0648\u0639\u0627\u062a <\/td>\nInfectious Diseases (except HIV\/AIDS)
\n\u0628\u06cc\u0645\u0627\u0631\u06cc \u0647\u0627\u06cc \u0639\u0641\u0648\u0646\u06cc (\u0628\u0647 \u062c\u0632 HIV\/AIDS)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\r\n\r\n \r\n \r\n \r\n \r\n
\u0641\u0631\u0645\u062a \u0627\u0631\u0627\u0626\u0647 \u062a\u0631\u062c\u0645\u0647 \u0645\u0642\u0627\u0644\u0647 <\/td>\r\n \u062a\u062d\u0648\u06cc\u0644 \u0628\u0647 \u0635\u0648\u0631\u062a \u0641\u0627\u06cc\u0644 \u0648\u0631\u062f<\/td>\r\n <\/tr>\r\n
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\u062c\u062f\u0627\u0648\u0644 \u0648 \u0641\u0631\u0645\u0648\u0644 \u0647\u0627 <\/td>\r\n \u06a9\u0644\u06cc\u0647 \u062c\u062f\u0627\u0648\u0644 \u0648 \u0641\u0631\u0645\u0648\u0644 \u0647\u0627 \u0646\u06cc\u0632 \u062f\u0631 \u0641\u0627\u06cc\u0644 \u062a\u062d\u0648\u06cc\u0644\u06cc \u0648\u0631\u062f \u062f\u0631\u062c \u0645\u06cc\u200c\u0634\u0648\u0646\u062f.<\/td>\r\n <\/tr>\r\n<\/table>\r\n\r\n\n

\u0686\u06a9\u06cc\u062f\u0647<\/h2>\n

The recent resurgence of Mpox in central Africa has been declared again a Public Health Emergency of International Concern (PHEIC) requiring coordinated international responses. Vaccination is a priority to expand protection and enhance control strategies, but the vaccine\u2019s need exceeds the currently available doses. Intradermal administration of one-fifth of the standard Modified-Vaccinia-Ankara (MVA-BN) dose was temporarily authorized during the 2022 PHEIC. Studies conducted before 2022 provided evidence about the humoral response against the Vaccinia virus (VACV) after vaccination but not against the Mpox virus (MPXV). Moreover, no data are available on the T-cell response elicited by MVA-BN administered subcutaneously or intradermally. Here, we compare the two vaccine administration routes according to reactogenicity and immunogenicity based on data from 943 vaccine recipients during the 2022 vaccination campaign in Rome, Italy. We found that the intradermal route elicited slightly higher titers of MPXV-specific IgG and nAbs than the subcutaneous one. At the same time, no differences in cellular response were detected. MVA-BN was globally well tolerated despite higher reactogenicity for the intradermal than the subcutaneous route, especially for the reactions at the local injection site. The intradermal dose-sparing strategy was proven safe and immunogenic and would make vaccination available to more people.<\/p>\n

\u0686\u06a9\u06cc\u062f\u0647 \u0628\u0647 \u0641\u0627\u0631\u0633\u06cc (\u062a\u0631\u062c\u0645\u0647 \u0645\u0627\u0634\u06cc\u0646\u06cc)<\/h2>\n

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