{"id":51253,"date":"2024-12-17T14:44:33","date_gmt":"2024-12-17T14:44:33","guid":{"rendered":""},"modified":"2024-12-17T14:44:33","modified_gmt":"2024-12-17T14:44:33","slug":"%d8%aa%d8%b1%d8%ac%d9%85%d9%87-%d9%81%d8%a7%d8%b1%d8%b3%db%8c-%d9%85%d9%82%d8%a7%d9%84%d9%87-51253","status":"publish","type":"product","link":"https:\/\/express24.ir\/d\/product\/%d8%aa%d8%b1%d8%ac%d9%85%d9%87-%d9%81%d8%a7%d8%b1%d8%b3%db%8c-%d9%85%d9%82%d8%a7%d9%84%d9%87-51253\/","title":{"rendered":"\u062a\u0631\u062c\u0645\u0647 \u0641\u0627\u0631\u0633\u06cc \u0645\u0642\u0627\u0644\u0647 \u0645\u06a9\u0627\u062a\u0628\u0627\u062a: \u062c\u0647\u0634 \u0645\u06a9\u0631\u0631 ECSIT \u06a9\u0647 V140A \u0631\u0627 \u06a9\u062f \u0645\u06cc \u06a9\u0646\u062f\u060c \u0628\u0627\u0639\u062b \u0627\u06cc\u062c\u0627\u062f \u0627\u0644\u062a\u0647\u0627\u0628 \u0634\u062f\u06cc\u062f \u0648 \u0633\u0646\u062f\u0631\u0645 \u0647\u0645\u0648\u0641\u0627\u06af\u0648\u0633\u06cc\u062a\u06cc\u06a9 \u062f\u0631 \u0644\u0646\u0641\u0648\u0645 \u0633\u0644\u0648\u0644 NK\/T \u062e\u0627\u0631\u062c \u06af\u0631\u0647\u06cc \u0645\u06cc \u0634\u0648\u062f."},"content":{"rendered":"\n\n\n\n\n\n\n\n\n\n\n\n
\u0639\u0646\u0648\u0627\u0646 \u0645\u0642\u0627\u0644\u0647 \u0628\u0647 \u0627\u0646\u06af\u0644\u06cc\u0633\u06cc <\/td>\nCorrespondence: Recurrent ECSIT mutation encoding V140A triggers hyperinflammation and promotes hemophagocytic syndrome in extranodal NK\/T cell lymphoma<\/td>\n<\/tr>\n
\u0639\u0646\u0648\u0627\u0646 \u0645\u0642\u0627\u0644\u0647 \u0628\u0647 \u0641\u0627\u0631\u0633\u06cc <\/td>\n\u062a\u0631\u062c\u0645\u0647 \u0641\u0627\u0631\u0633\u06cc \u0645\u0642\u0627\u0644\u0647 \u0645\u06a9\u0627\u062a\u0628\u0627\u062a: \u062c\u0647\u0634 \u0645\u06a9\u0631\u0631 ECSIT \u06a9\u0647 V140A \u0631\u0627 \u06a9\u062f \u0645\u06cc \u06a9\u0646\u062f\u060c \u0628\u0627\u0639\u062b \u0627\u06cc\u062c\u0627\u062f \u0627\u0644\u062a\u0647\u0627\u0628 \u0634\u062f\u06cc\u062f \u0648 \u0633\u0646\u062f\u0631\u0645 \u0647\u0645\u0648\u0641\u0627\u06af\u0648\u0633\u06cc\u062a\u06cc\u06a9 \u062f\u0631 \u0644\u0646\u0641\u0648\u0645 \u0633\u0644\u0648\u0644 NK\/T \u062e\u0627\u0631\u062c \u06af\u0631\u0647\u06cc \u0645\u06cc \u0634\u0648\u062f.<\/td>\n<\/tr>\n
\u0646\u0648\u06cc\u0633\u0646\u062f\u06af\u0627\u0646 <\/td>\n ProfileJing Quan Lim, ProfileDachuan Huang, ProfileChoon Kiat Ong<\/td>\n<\/tr>\n
\u0641\u0631\u0645\u062a \u0645\u0642\u0627\u0644\u0647 \u0627\u0646\u06af\u0644\u06cc\u0633\u06cc <\/td>\nPDF<\/td>\n<\/tr>\n
\u0632\u0628\u0627\u0646 \u0645\u0642\u0627\u0644\u0647 \u062a\u062d\u0648\u06cc\u0644\u06cc <\/td>\n\u062a\u0631\u062c\u0645\u0647 \u0641\u0627\u0631\u0633\u06cc<\/td>\n<\/tr>\n
\u0641\u0631\u0645\u062a \u0645\u0642\u0627\u0644\u0647 \u062a\u0631\u062c\u0645\u0647 \u0634\u062f\u0647 <\/td>\n\u0628\u0647 \u0635\u0648\u0631\u062a \u0641\u0627\u06cc\u0644 \u0648\u0631\u062f<\/td>\n<\/tr>\n
\u0646\u062d\u0648\u0647 \u062a\u062d\u0648\u06cc\u0644 \u062a\u0631\u062c\u0645\u0647 <\/td>\n\u062f\u0648 \u062a\u0627 \u0633\u0647 \u0631\u0648\u0632 \u067e\u0633 \u0627\u0632 \u062b\u0628\u062a \u0633\u0641\u0627\u0631\u0634 (\u0628\u0647 \u0635\u0648\u0631\u062a \u0641\u0627\u06cc\u0644 \u062f\u0627\u0646\u0644\u0648\u062f\u06cc)<\/td>\n<\/tr>\n
\u062a\u0639\u062f\u0627\u062f \u0635\u0641\u062d\u0627\u062a<\/td>\n9<\/td>\n<\/tr>\n
\u0644\u06cc\u0646\u06a9 \u062f\u0627\u0646\u0644\u0648\u062f \u0631\u0627\u06cc\u06af\u0627\u0646 \u0645\u0642\u0627\u0644\u0647 \u0627\u0646\u06af\u0644\u06cc\u0633\u06cc<\/td>\n\u062f\u0627\u0646\u0644\u0648\u062f \u0645\u0642\u0627\u0644\u0647<\/a><\/td>\n<\/tr>\n
\u062f\u0633\u062a\u0647 \u0628\u0646\u062f\u06cc \u0645\u0648\u0636\u0648\u0639\u0627\u062a <\/td>\nAllergy and Immunology
\n\u062d\u0633\u0627\u0633\u06cc\u062a \u0648 \u0627\u06cc\u0645\u0648\u0646\u0648\u0644\u0648\u0698\u06cc<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\r\n\r\n \r\n \r\n \r\n \r\n
\u0641\u0631\u0645\u062a \u0627\u0631\u0627\u0626\u0647 \u062a\u0631\u062c\u0645\u0647 \u0645\u0642\u0627\u0644\u0647 <\/td>\r\n \u062a\u062d\u0648\u06cc\u0644 \u0628\u0647 \u0635\u0648\u0631\u062a \u0641\u0627\u06cc\u0644 \u0648\u0631\u062f<\/td>\r\n <\/tr>\r\n
\u0632\u0645\u0627\u0646 \u062a\u062d\u0648\u06cc\u0644 \u062a\u0631\u062c\u0645\u0647 \u0645\u0642\u0627\u0644\u0647 <\/td>\r\n \u0628\u06cc\u0646 2 \u062a\u0627 3 \u0631\u0648\u0632 \u067e\u0633 \u0627\u0632 \u062b\u0628\u062a \u0633\u0641\u0627\u0631\u0634<\/td>\r\n <\/tr>\r\n\t
\u06a9\u06cc\u0641\u06cc\u062a \u062a\u0631\u062c\u0645\u0647 <\/td>\r\n \u0628\u0633\u06cc\u0627\u0631 \u0628\u0627\u0644\u0627. \u0645\u0642\u0627\u0644\u0647 \u0641\u0642\u0637 \u062a\u0648\u0633\u0637 \u0645\u062a\u0631\u062c\u0645\u06cc\u0646 \u0628\u0627 \u0645\u062f\u0631\u06a9 \u062f\u0627\u0646\u0634\u06af\u0627\u0647\u06cc \u0645\u062a\u0631\u062c\u0645\u06cc \u062a\u0631\u062c\u0645\u0647 \u0645\u06cc\u200c\u0634\u0648\u062f.<\/td>\r\n <\/tr>\r\n\t\t
\u062c\u062f\u0627\u0648\u0644 \u0648 \u0641\u0631\u0645\u0648\u0644 \u0647\u0627 <\/td>\r\n \u06a9\u0644\u06cc\u0647 \u062c\u062f\u0627\u0648\u0644 \u0648 \u0641\u0631\u0645\u0648\u0644 \u0647\u0627 \u0646\u06cc\u0632 \u062f\u0631 \u0641\u0627\u06cc\u0644 \u062a\u062d\u0648\u06cc\u0644\u06cc \u0648\u0631\u062f \u062f\u0631\u062c \u0645\u06cc\u200c\u0634\u0648\u0646\u062f.<\/td>\r\n <\/tr>\r\n<\/table>\r\n\r\n\n

\u0686\u06a9\u06cc\u062f\u0647<\/h2>\n

Recurrent somatic mutation in the ECSIT gene encoding p.V140A was reported in 19.3% (17\/88) extranodal natural-killer\/T cell lymphoma (ENKTL) and was associated with hemophagocytic syndrome (HPS). However, another cohort of similar geographical descent also had the ECSITV140A mutation as germline in 20.0% (5\/25) of ENKTL and none were somatic. The reanalysis of published data revealed that the reported somatic ECSITV140A could be germline as well. First-digit analysis on the IDs of sequencing read also found irregularity among the data that initially reported the somatic ECSITV140A mutation. As such, this study questions the only somatic genetic link of HPS in ENKTL and also introduces a simple well-known algorithm to detect data irregularity in voluminous genomic sequencing data.<\/p>\n

\u0686\u06a9\u06cc\u062f\u0647 \u0628\u0647 \u0641\u0627\u0631\u0633\u06cc (\u062a\u0631\u062c\u0645\u0647 \u0645\u0627\u0634\u06cc\u0646\u06cc)<\/h2>\n

\u062c\u0647\u0634 \u0633\u0648\u0645\u0627\u062a\u06cc\u06a9 \u0645\u06a9\u0631\u0631 \u062f\u0631 \u0631\u0645\u0632\u06af\u0630\u0627\u0631\u06cc \u0698\u0646 ECSIT P.V140A \u062f\u0631 19.3 \u066a (17\/88) \u0644\u0646\u0641\u0648\u0645 \u0633\u0644\u0648\u0644 \u0637\u0628\u06cc\u0639\u06cc\/\u0633\u0644\u0648\u0644 T (ENKTL) \u0627\u06a9\u0633\u062a\u0631\u0627\u0646\u0648\u062f\u0627\u0644 \u06af\u0632\u0627\u0631\u0634 \u0634\u062f \u0648 \u0628\u0627 \u0633\u0646\u062f\u0631\u0645 \u0647\u0645\u0648\u0641\u0627\u0698\u0648\u0633\u06cc\u062a\u06cc\u06a9 (HPS) \u0647\u0645\u0631\u0627\u0647 \u0628\u0648\u062f.\u0628\u0627 \u0627\u06cc\u0646 \u062d\u0627\u0644 \u060c \u06cc\u06a9 \u06af\u0631\u0648\u0647 \u062f\u06cc\u06af\u0631 \u0627\u0632 \u0646\u0632\u0648\u0644 \u062c\u063a\u0631\u0627\u0641\u06cc\u0627\u06cc\u06cc \u0645\u0634\u0627\u0628\u0647 \u0646\u06cc\u0632 \u062c\u0647\u0634 ECSITV140A \u0631\u0627 \u0628\u0647 \u0639\u0646\u0648\u0627\u0646 \u0645\u06cc\u06a9\u0631\u0648\u0628 \u062f\u0631 20.0 \u066a (5\/25) ENKTL \u0648 \u0647\u06cc\u0686 \u06cc\u06a9 \u062c\u0633\u0645\u06cc \u0646\u062f\u0627\u0634\u062a\u0646\u062f.\u062a\u062c\u0632\u06cc\u0647 \u0648 \u062a\u062d\u0644\u06cc\u0644 \u0645\u062c\u062f\u062f \u062f\u0627\u062f\u0647 \u0647\u0627\u06cc \u0645\u0646\u062a\u0634\u0631 \u0634\u062f\u0647 \u0646\u0634\u0627\u0646 \u062f\u0627\u062f \u06a9\u0647 ECSITV140A \u0633\u0648\u0645\u0627\u062a\u06cc\u06a9 \u06af\u0632\u0627\u0631\u0634 \u0634\u062f\u0647 \u0646\u06cc\u0632 \u0645\u06cc \u062a\u0648\u0627\u0646\u062f Germline \u0628\u0627\u0634\u062f.\u062a\u062c\u0632\u06cc\u0647 \u0648 \u062a\u062d\u0644\u06cc\u0644 \u0631\u0642\u0645 \u0627\u0648\u0644 \u062f\u0631 IDS \u062a\u0648\u0627\u0644\u06cc \u062e\u0648\u0627\u0646\u062f\u0647 \u0634\u062f\u0647 \u0647\u0645\u0686\u0646\u06cc\u0646 \u0628\u06cc \u0646\u0638\u0645\u06cc \u062f\u0631 \u0628\u06cc\u0646 \u062f\u0627\u062f\u0647 \u0647\u0627\u06cc\u06cc \u06a9\u0647 \u062f\u0631 \u0627\u0628\u062a\u062f\u0627 \u062c\u0647\u0634 ECSITV140A \u0633\u0648\u0645\u0627\u062a\u06cc\u06a9 \u0631\u0627 \u06af\u0632\u0627\u0631\u0634 \u06a9\u0631\u062f\u0646\u062f \u060c \u0646\u0634\u0627\u0646 \u062f\u0627\u062f.\u0628\u0647 \u0647\u0645\u06cc\u0646 \u062a\u0631\u062a\u06cc\u0628 \u060c \u0627\u06cc\u0646 \u0645\u0637\u0627\u0644\u0639\u0647 \u062a\u0646\u0647\u0627 \u067e\u06cc\u0648\u0646\u062f \u0698\u0646\u062a\u06cc\u06a9\u06cc \u062c\u0633\u0645\u06cc HPS \u062f\u0631 ENKTL \u0631\u0627 \u0632\u06cc\u0631 \u0633\u0648\u0627\u0644 \u0645\u06cc \u0628\u0631\u062f \u0648 \u0647\u0645\u0686\u0646\u06cc\u0646 \u06cc\u06a9 \u0627\u0644\u06af\u0648\u0631\u06cc\u062a\u0645 \u0633\u0627\u062f\u0647 \u0634\u0646\u0627\u062e\u062a\u0647 \u0634\u062f\u0647 \u0631\u0627 \u0628\u0631\u0627\u06cc \u062a\u0634\u062e\u06cc\u0635 \u0628\u06cc \u0646\u0638\u0645\u06cc \u062f\u0627\u062f\u0647 \u0647\u0627 \u062f\u0631 \u062f\u0627\u062f\u0647 \u0647\u0627\u06cc \u062a\u0648\u0627\u0644\u06cc \u0698\u0646\u0648\u0645\u06cc \u062d\u062c\u0645\u06cc \u0645\u0639\u0631\u0641\u06cc \u0645\u06cc \u06a9\u0646\u062f.<\/p>\n\r\n\r\n \r\n \r\n \r\n \r\n
\u0641\u0631\u0645\u062a \u0627\u0631\u0627\u0626\u0647 \u062a\u0631\u062c\u0645\u0647 \u0645\u0642\u0627\u0644\u0647 <\/td>\r\n \u062a\u062d\u0648\u06cc\u0644 \u0628\u0647 \u0635\u0648\u0631\u062a \u0641\u0627\u06cc\u0644 \u0648\u0631\u062f<\/td>\r\n <\/tr>\r\n
\u0632\u0645\u0627\u0646 \u062a\u062d\u0648\u06cc\u0644 \u062a\u0631\u062c\u0645\u0647 \u0645\u0642\u0627\u0644\u0647 <\/td>\r\n \u0628\u06cc\u0646 2 \u062a\u0627 3 \u0631\u0648\u0632 \u067e\u0633 \u0627\u0632 \u062b\u0628\u062a \u0633\u0641\u0627\u0631\u0634<\/td>\r\n <\/tr>\r\n\t
\u06a9\u06cc\u0641\u06cc\u062a \u062a\u0631\u062c\u0645\u0647 <\/td>\r\n \u0628\u0633\u06cc\u0627\u0631 \u0628\u0627\u0644\u0627. \u0645\u0642\u0627\u0644\u0647 \u0641\u0642\u0637 \u062a\u0648\u0633\u0637 \u0645\u062a\u0631\u062c\u0645\u06cc\u0646 \u0628\u0627 \u0645\u062f\u0631\u06a9 \u062f\u0627\u0646\u0634\u06af\u0627\u0647\u06cc \u0645\u062a\u0631\u062c\u0645\u06cc \u062a\u0631\u062c\u0645\u0647 \u0645\u06cc\u200c\u0634\u0648\u062f.<\/td>\r\n <\/tr>\r\n\t\t
\u062c\u062f\u0627\u0648\u0644 \u0648 \u0641\u0631\u0645\u0648\u0644 \u0647\u0627 <\/td>\r\n \u06a9\u0644\u06cc\u0647 \u062c\u062f\u0627\u0648\u0644 \u0648 \u0641\u0631\u0645\u0648\u0644 \u0647\u0627 \u0646\u06cc\u0632 \u062f\u0631 \u0641\u0627\u06cc\u0644 \u062a\u062d\u0648\u06cc\u0644\u06cc \u0648\u0631\u062f \u062f\u0631\u062c \u0645\u06cc\u200c\u0634\u0648\u0646\u062f.<\/td>\r\n <\/tr>\r\n<\/table>\r\n\r\n\n","protected":false},"excerpt":{"rendered":"

\u0639\u0646\u0648\u0627\u0646 \u0645\u0642\u0627\u0644\u0647 \u0628\u0647 \u0627\u0646\u06af\u0644\u06cc\u0633\u06cc Correspondence: Recurrent ECSIT mutation encoding V140A triggers hyperinflammation and promotes hemophagocytic syndrome in extranodal NK\/T cell […]<\/p>\n","protected":false},"featured_media":27,"comment_status":"open","ping_status":"open","template":"","meta":{"pmpro_default_level":"","site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}}},"product_cat":[21],"product_tag":[],"class_list":{"0":"post-51253","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-21","7":"pmpro-has-access","8":"desktop-align-left","9":"tablet-align-left","10":"mobile-align-left","12":"first","13":"instock","14":"downloadable","15":"shipping-taxable","16":"purchasable","17":"product-type-simple"},"yoast_head":"\n\u062a\u0631\u062c\u0645\u0647 \u0641\u0627\u0631\u0633\u06cc \u0645\u0642\u0627\u0644\u0647 \u0645\u06a9\u0627\u062a\u0628\u0627\u062a: \u062c\u0647\u0634 \u0645\u06a9\u0631\u0631 ECSIT \u06a9\u0647 V140A \u0631\u0627 \u06a9\u062f \u0645\u06cc \u06a9\u0646\u062f\u060c \u0628\u0627\u0639\u062b \u0627\u06cc\u062c\u0627\u062f \u0627\u0644\u062a\u0647\u0627\u0628 \u0634\u062f\u06cc\u062f \u0648 \u0633\u0646\u062f\u0631\u0645 \u0647\u0645\u0648\u0641\u0627\u06af\u0648\u0633\u06cc\u062a\u06cc\u06a9 \u062f\u0631 \u0644\u0646\u0641\u0648\u0645 \u0633\u0644\u0648\u0644 NK\/T \u062e\u0627\u0631\u062c \u06af\u0631\u0647\u06cc \u0645\u06cc \u0634\u0648\u062f. - \u0641\u0631\u0648\u0634\u06af\u0627\u0647 \u0627\u06a9\u0633\u067e\u0631\u0633<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/express24.ir\/d\/product\/\u062a\u0631\u062c\u0645\u0647-\u0641\u0627\u0631\u0633\u06cc-\u0645\u0642\u0627\u0644\u0647-51253\/\" \/>\n<meta property=\"og:locale\" content=\"fa_IR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u062a\u0631\u062c\u0645\u0647 \u0641\u0627\u0631\u0633\u06cc \u0645\u0642\u0627\u0644\u0647 \u0645\u06a9\u0627\u062a\u0628\u0627\u062a: \u062c\u0647\u0634 \u0645\u06a9\u0631\u0631 ECSIT \u06a9\u0647 V140A \u0631\u0627 \u06a9\u062f \u0645\u06cc \u06a9\u0646\u062f\u060c \u0628\u0627\u0639\u062b \u0627\u06cc\u062c\u0627\u062f \u0627\u0644\u062a\u0647\u0627\u0628 \u0634\u062f\u06cc\u062f \u0648 \u0633\u0646\u062f\u0631\u0645 \u0647\u0645\u0648\u0641\u0627\u06af\u0648\u0633\u06cc\u062a\u06cc\u06a9 \u062f\u0631 \u0644\u0646\u0641\u0648\u0645 \u0633\u0644\u0648\u0644 NK\/T \u062e\u0627\u0631\u062c \u06af\u0631\u0647\u06cc \u0645\u06cc \u0634\u0648\u062f. - \u0641\u0631\u0648\u0634\u06af\u0627\u0647 \u0627\u06a9\u0633\u067e\u0631\u0633\" \/>\n<meta property=\"og:description\" content=\"\u0639\u0646\u0648\u0627\u0646 \u0645\u0642\u0627\u0644\u0647 \u0628\u0647 \u0627\u0646\u06af\u0644\u06cc\u0633\u06cc Correspondence: Recurrent ECSIT mutation encoding V140A triggers hyperinflammation and promotes hemophagocytic syndrome in extranodal NK\/T cell […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/express24.ir\/d\/product\/\u062a\u0631\u062c\u0645\u0647-\u0641\u0627\u0631\u0633\u06cc-\u0645\u0642\u0627\u0644\u0647-51253\/\" \/>\n<meta property=\"og:site_name\" content=\"\u0641\u0631\u0648\u0634\u06af\u0627\u0647 \u0627\u06a9\u0633\u067e\u0631\u0633\" \/>\n<meta property=\"og:image\" content=\"https:\/\/express24.ir\/d\/wp-content\/uploads\/2024\/02\/Elsevier_logo_2019.svg_.png\" \/>\n\t<meta property=\"og:image:width\" content=\"440\" \/>\n\t<meta property=\"og:image:height\" content=\"486\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"\u0632\u0645\u0627\u0646 \u062a\u0642\u0631\u06cc\u0628\u06cc \u0628\u0631\u0627\u06cc \u062e\u0648\u0627\u0646\u062f\u0646\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 \u062f\u0642\u06cc\u0642\u0647\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/express24.ir\/d\/product\/%d8%aa%d8%b1%d8%ac%d9%85%d9%87-%d9%81%d8%a7%d8%b1%d8%b3%db%8c-%d9%85%d9%82%d8%a7%d9%84%d9%87-51253\/\",\"url\":\"https:\/\/express24.ir\/d\/product\/%d8%aa%d8%b1%d8%ac%d9%85%d9%87-%d9%81%d8%a7%d8%b1%d8%b3%db%8c-%d9%85%d9%82%d8%a7%d9%84%d9%87-51253\/\",\"name\":\"\u062a\u0631\u062c\u0645\u0647 \u0641\u0627\u0631\u0633\u06cc \u0645\u0642\u0627\u0644\u0647 \u0645\u06a9\u0627\u062a\u0628\u0627\u062a: \u062c\u0647\u0634 \u0645\u06a9\u0631\u0631 ECSIT \u06a9\u0647 V140A \u0631\u0627 \u06a9\u062f \u0645\u06cc \u06a9\u0646\u062f\u060c \u0628\u0627\u0639\u062b \u0627\u06cc\u062c\u0627\u062f \u0627\u0644\u062a\u0647\u0627\u0628 \u0634\u062f\u06cc\u062f \u0648 \u0633\u0646\u062f\u0631\u0645 \u0647\u0645\u0648\u0641\u0627\u06af\u0648\u0633\u06cc\u062a\u06cc\u06a9 \u062f\u0631 \u0644\u0646\u0641\u0648\u0645 \u0633\u0644\u0648\u0644 NK\/T \u062e\u0627\u0631\u062c \u06af\u0631\u0647\u06cc \u0645\u06cc \u0634\u0648\u062f. - \u0641\u0631\u0648\u0634\u06af\u0627\u0647 \u0627\u06a9\u0633\u067e\u0631\u0633\",\"isPartOf\":{\"@id\":\"https:\/\/express24.ir\/d\/#website\"},\"datePublished\":\"2024-12-17T14:44:33+00:00\",\"dateModified\":\"2024-12-17T14:44:33+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/express24.ir\/d\/product\/%d8%aa%d8%b1%d8%ac%d9%85%d9%87-%d9%81%d8%a7%d8%b1%d8%b3%db%8c-%d9%85%d9%82%d8%a7%d9%84%d9%87-51253\/#breadcrumb\"},\"inLanguage\":\"fa-IR\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/express24.ir\/d\/product\/%d8%aa%d8%b1%d8%ac%d9%85%d9%87-%d9%81%d8%a7%d8%b1%d8%b3%db%8c-%d9%85%d9%82%d8%a7%d9%84%d9%87-51253\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/express24.ir\/d\/product\/%d8%aa%d8%b1%d8%ac%d9%85%d9%87-%d9%81%d8%a7%d8%b1%d8%b3%db%8c-%d9%85%d9%82%d8%a7%d9%84%d9%87-51253\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u062e\u0627\u0646\u0647\",\"item\":\"https:\/\/express24.ir\/d\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"\u0641\u0631\u0648\u0634\u06af\u0627\u0647\",\"item\":\"https:\/\/express24.ir\/d\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"\u062a\u0631\u062c\u0645\u0647 \u0641\u0627\u0631\u0633\u06cc \u0645\u0642\u0627\u0644\u0647 \u0645\u06a9\u0627\u062a\u0628\u0627\u062a: \u062c\u0647\u0634 \u0645\u06a9\u0631\u0631 ECSIT \u06a9\u0647 V140A \u0631\u0627 \u06a9\u062f \u0645\u06cc \u06a9\u0646\u062f\u060c \u0628\u0627\u0639\u062b \u0627\u06cc\u062c\u0627\u062f \u0627\u0644\u062a\u0647\u0627\u0628 \u0634\u062f\u06cc\u062f \u0648 \u0633\u0646\u062f\u0631\u0645 \u0647\u0645\u0648\u0641\u0627\u06af\u0648\u0633\u06cc\u062a\u06cc\u06a9 \u062f\u0631 \u0644\u0646\u0641\u0648\u0645 \u0633\u0644\u0648\u0644 NK\/T \u062e\u0627\u0631\u062c \u06af\u0631\u0647\u06cc \u0645\u06cc \u0634\u0648\u062f.\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/express24.ir\/d\/#website\",\"url\":\"https:\/\/express24.ir\/d\/\",\"name\":\"\u0641\u0631\u0648\u0634\u06af\u0627\u0647 \u0627\u06a9\u0633\u067e\u0631\u0633\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/express24.ir\/d\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"fa-IR\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"\u062a\u0631\u062c\u0645\u0647 \u0641\u0627\u0631\u0633\u06cc \u0645\u0642\u0627\u0644\u0647 \u0645\u06a9\u0627\u062a\u0628\u0627\u062a: \u062c\u0647\u0634 \u0645\u06a9\u0631\u0631 ECSIT \u06a9\u0647 V140A \u0631\u0627 \u06a9\u062f \u0645\u06cc \u06a9\u0646\u062f\u060c \u0628\u0627\u0639\u062b \u0627\u06cc\u062c\u0627\u062f \u0627\u0644\u062a\u0647\u0627\u0628 \u0634\u062f\u06cc\u062f \u0648 \u0633\u0646\u062f\u0631\u0645 \u0647\u0645\u0648\u0641\u0627\u06af\u0648\u0633\u06cc\u062a\u06cc\u06a9 \u062f\u0631 \u0644\u0646\u0641\u0648\u0645 \u0633\u0644\u0648\u0644 NK\/T \u062e\u0627\u0631\u062c \u06af\u0631\u0647\u06cc \u0645\u06cc \u0634\u0648\u062f. - \u0641\u0631\u0648\u0634\u06af\u0627\u0647 \u0627\u06a9\u0633\u067e\u0631\u0633","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/express24.ir\/d\/product\/\u062a\u0631\u062c\u0645\u0647-\u0641\u0627\u0631\u0633\u06cc-\u0645\u0642\u0627\u0644\u0647-51253\/","og_locale":"fa_IR","og_type":"article","og_title":"\u062a\u0631\u062c\u0645\u0647 \u0641\u0627\u0631\u0633\u06cc \u0645\u0642\u0627\u0644\u0647 \u0645\u06a9\u0627\u062a\u0628\u0627\u062a: \u062c\u0647\u0634 \u0645\u06a9\u0631\u0631 ECSIT \u06a9\u0647 V140A \u0631\u0627 \u06a9\u062f \u0645\u06cc \u06a9\u0646\u062f\u060c \u0628\u0627\u0639\u062b \u0627\u06cc\u062c\u0627\u062f \u0627\u0644\u062a\u0647\u0627\u0628 \u0634\u062f\u06cc\u062f \u0648 \u0633\u0646\u062f\u0631\u0645 \u0647\u0645\u0648\u0641\u0627\u06af\u0648\u0633\u06cc\u062a\u06cc\u06a9 \u062f\u0631 \u0644\u0646\u0641\u0648\u0645 \u0633\u0644\u0648\u0644 NK\/T \u062e\u0627\u0631\u062c \u06af\u0631\u0647\u06cc \u0645\u06cc \u0634\u0648\u062f. - \u0641\u0631\u0648\u0634\u06af\u0627\u0647 \u0627\u06a9\u0633\u067e\u0631\u0633","og_description":"\u0639\u0646\u0648\u0627\u0646 \u0645\u0642\u0627\u0644\u0647 \u0628\u0647 \u0627\u0646\u06af\u0644\u06cc\u0633\u06cc Correspondence: Recurrent ECSIT mutation encoding V140A triggers hyperinflammation and promotes hemophagocytic syndrome in extranodal NK\/T cell […]","og_url":"https:\/\/express24.ir\/d\/product\/\u062a\u0631\u062c\u0645\u0647-\u0641\u0627\u0631\u0633\u06cc-\u0645\u0642\u0627\u0644\u0647-51253\/","og_site_name":"\u0641\u0631\u0648\u0634\u06af\u0627\u0647 \u0627\u06a9\u0633\u067e\u0631\u0633","og_image":[{"width":440,"height":486,"url":"https:\/\/express24.ir\/d\/wp-content\/uploads\/2024\/02\/Elsevier_logo_2019.svg_.png","type":"image\/png"}],"twitter_card":"summary_large_image","twitter_misc":{"\u0632\u0645\u0627\u0646 \u062a\u0642\u0631\u06cc\u0628\u06cc \u0628\u0631\u0627\u06cc \u062e\u0648\u0627\u0646\u062f\u0646":"1 \u062f\u0642\u06cc\u0642\u0647"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/express24.ir\/d\/product\/%d8%aa%d8%b1%d8%ac%d9%85%d9%87-%d9%81%d8%a7%d8%b1%d8%b3%db%8c-%d9%85%d9%82%d8%a7%d9%84%d9%87-51253\/","url":"https:\/\/express24.ir\/d\/product\/%d8%aa%d8%b1%d8%ac%d9%85%d9%87-%d9%81%d8%a7%d8%b1%d8%b3%db%8c-%d9%85%d9%82%d8%a7%d9%84%d9%87-51253\/","name":"\u062a\u0631\u062c\u0645\u0647 \u0641\u0627\u0631\u0633\u06cc \u0645\u0642\u0627\u0644\u0647 \u0645\u06a9\u0627\u062a\u0628\u0627\u062a: \u062c\u0647\u0634 \u0645\u06a9\u0631\u0631 ECSIT \u06a9\u0647 V140A \u0631\u0627 \u06a9\u062f \u0645\u06cc \u06a9\u0646\u062f\u060c \u0628\u0627\u0639\u062b \u0627\u06cc\u062c\u0627\u062f \u0627\u0644\u062a\u0647\u0627\u0628 \u0634\u062f\u06cc\u062f \u0648 \u0633\u0646\u062f\u0631\u0645 \u0647\u0645\u0648\u0641\u0627\u06af\u0648\u0633\u06cc\u062a\u06cc\u06a9 \u062f\u0631 \u0644\u0646\u0641\u0648\u0645 \u0633\u0644\u0648\u0644 NK\/T \u062e\u0627\u0631\u062c \u06af\u0631\u0647\u06cc \u0645\u06cc \u0634\u0648\u062f. - \u0641\u0631\u0648\u0634\u06af\u0627\u0647 \u0627\u06a9\u0633\u067e\u0631\u0633","isPartOf":{"@id":"https:\/\/express24.ir\/d\/#website"},"datePublished":"2024-12-17T14:44:33+00:00","dateModified":"2024-12-17T14:44:33+00:00","breadcrumb":{"@id":"https:\/\/express24.ir\/d\/product\/%d8%aa%d8%b1%d8%ac%d9%85%d9%87-%d9%81%d8%a7%d8%b1%d8%b3%db%8c-%d9%85%d9%82%d8%a7%d9%84%d9%87-51253\/#breadcrumb"},"inLanguage":"fa-IR","potentialAction":[{"@type":"ReadAction","target":["https:\/\/express24.ir\/d\/product\/%d8%aa%d8%b1%d8%ac%d9%85%d9%87-%d9%81%d8%a7%d8%b1%d8%b3%db%8c-%d9%85%d9%82%d8%a7%d9%84%d9%87-51253\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/express24.ir\/d\/product\/%d8%aa%d8%b1%d8%ac%d9%85%d9%87-%d9%81%d8%a7%d8%b1%d8%b3%db%8c-%d9%85%d9%82%d8%a7%d9%84%d9%87-51253\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"\u062e\u0627\u0646\u0647","item":"https:\/\/express24.ir\/d\/"},{"@type":"ListItem","position":2,"name":"\u0641\u0631\u0648\u0634\u06af\u0627\u0647","item":"https:\/\/express24.ir\/d\/"},{"@type":"ListItem","position":3,"name":"\u062a\u0631\u062c\u0645\u0647 \u0641\u0627\u0631\u0633\u06cc \u0645\u0642\u0627\u0644\u0647 \u0645\u06a9\u0627\u062a\u0628\u0627\u062a: \u062c\u0647\u0634 \u0645\u06a9\u0631\u0631 ECSIT \u06a9\u0647 V140A \u0631\u0627 \u06a9\u062f \u0645\u06cc \u06a9\u0646\u062f\u060c \u0628\u0627\u0639\u062b \u0627\u06cc\u062c\u0627\u062f \u0627\u0644\u062a\u0647\u0627\u0628 \u0634\u062f\u06cc\u062f \u0648 \u0633\u0646\u062f\u0631\u0645 \u0647\u0645\u0648\u0641\u0627\u06af\u0648\u0633\u06cc\u062a\u06cc\u06a9 \u062f\u0631 \u0644\u0646\u0641\u0648\u0645 \u0633\u0644\u0648\u0644 NK\/T \u062e\u0627\u0631\u062c \u06af\u0631\u0647\u06cc \u0645\u06cc \u0634\u0648\u062f."}]},{"@type":"WebSite","@id":"https:\/\/express24.ir\/d\/#website","url":"https:\/\/express24.ir\/d\/","name":"\u0641\u0631\u0648\u0634\u06af\u0627\u0647 \u0627\u06a9\u0633\u067e\u0631\u0633","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/express24.ir\/d\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"fa-IR"}]}},"_links":{"self":[{"href":"https:\/\/express24.ir\/d\/wp-json\/wp\/v2\/product\/51253","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/express24.ir\/d\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/express24.ir\/d\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/express24.ir\/d\/wp-json\/wp\/v2\/comments?post=51253"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/express24.ir\/d\/wp-json\/wp\/v2\/media\/27"}],"wp:attachment":[{"href":"https:\/\/express24.ir\/d\/wp-json\/wp\/v2\/media?parent=51253"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/express24.ir\/d\/wp-json\/wp\/v2\/product_cat?post=51253"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/express24.ir\/d\/wp-json\/wp\/v2\/product_tag?post=51253"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}