{"id":51207,"date":"2024-12-17T14:09:25","date_gmt":"2024-12-17T14:09:25","guid":{"rendered":""},"modified":"2024-12-17T14:09:25","modified_gmt":"2024-12-17T14:09:25","slug":"%d8%aa%d8%b1%d8%ac%d9%85%d9%87-%d9%81%d8%a7%d8%b1%d8%b3%db%8c-%d9%85%d9%82%d8%a7%d9%84%d9%87-51207","status":"publish","type":"product","link":"https:\/\/express24.ir\/d\/product\/%d8%aa%d8%b1%d8%ac%d9%85%d9%87-%d9%81%d8%a7%d8%b1%d8%b3%db%8c-%d9%85%d9%82%d8%a7%d9%84%d9%87-51207\/","title":{"rendered":"\u062a\u0631\u062c\u0645\u0647 \u0641\u0627\u0631\u0633\u06cc \u0645\u0642\u0627\u0644\u0647 \u0645\u0637\u0627\u0644\u0639\u0647 \u0627\u0646\u062c\u0645\u0646 \u06af\u0633\u062a\u0631\u062f\u0647 \u0698\u0646\u0648\u0645 \u062f\u0631 \u0645\u0648\u0631\u062f \u0627\u0646\u0632\u0648\u0627\u06cc \u0627\u062c\u062a\u0645\u0627\u0639\u06cc \u062f\u0631 63497 \u0698\u0627\u067e\u0646\u06cc \u0627\u0632 \u062c\u0645\u0639\u06cc\u062a \u0639\u0645\u0648\u0645\u06cc"},"content":{"rendered":"\n\n\n\n\n\n\n\n\n\n\n\n
\u0639\u0646\u0648\u0627\u0646 \u0645\u0642\u0627\u0644\u0647 \u0628\u0647 \u0627\u0646\u06af\u0644\u06cc\u0633\u06cc <\/td>\nGenome-wide Association Study of Social Isolation in 63 497 Japanese Individuals from the General Population<\/td>\n<\/tr>\n
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\u0646\u0648\u06cc\u0633\u0646\u062f\u06af\u0627\u0646 <\/td>\nHisashi Ohseto, Kosuke Inoue, Ippei Takahashi, Taku Obara, Akira Narita, Mami Ishikuro, Masatsugu Orui, Keiko Murakami, Aoi Noda, Genki Shinoda, Masato Takase, Naoki Nakaya, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Ippei Chiba, Sayuri Tokioka, Yuka Kotozaki, Atsushi Shimizu, Kozo Tanno, Atsushi Hozawa, Gen Tamiya, Naoki Kondo, Shinichi Kuriyama<\/td>\n<\/tr>\n
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\u062f\u0633\u062a\u0647 \u0628\u0646\u062f\u06cc \u0645\u0648\u0636\u0648\u0639\u0627\u062a <\/td>\nGenetic and Genomic Medicine
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\u0686\u06a9\u06cc\u062f\u0647<\/h2>\n

Social isolation, characterized by a lack of social connections with family, friends, and others, is associated with adverse health outcomes. However, the genetic contribution to the susceptibility to social isolation remains unclear. This study aimed to identify genetic loci associated with social isolation using the Lubben Social Network Scale (LSNS-6) in a Japanese population. The Tohoku Medical Megabank Community-Based Cohort Study was conducted between 2013 and 2016. The participants were genotyped using the Affymetrix Axiom Japonica Array. The LSNS-6 was used to assess familial and friend ties through six questions and social isolation statuses were defined as total scale, family subscale, and friend subscale. Genome-wide association studies (GWASs) were conducted using a generalized linear mixed model, adjusting for age, sex, and 10 genetic principal components. In total, 63 497 participants who completed genotyping and the LSNS-6 were included. The mean age was 59.4\u00b111.9 years, and 41 126 (64.8%) were female. Significant genetic loci were identified in GWASs for the total scale (rs10736933 near ACADSB and HMX3) and friend subscale of LSNS-6 (rs1778366 near LINC02315 and LRFN5). This study provides the first genome-wide evidence of social isolation in the Japanese population, suggesting associations with ACADSB, HMX3, LINC02315, and LRFN5. These findings could enable personalized prevention and intervention for social isolation and related psychiatric disorders.<\/p>\n

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126 \u0646\u0641\u0631 (8 \/64 \u066a) \u0632\u0646 \u0628\u0648\u062f\u0646\u062f.\u0645\u06a9\u0627\u0646\u0647\u0627\u06cc \u0698\u0646\u062a\u06cc\u06a9\u06cc \u0642\u0627\u0628\u0644 \u062a\u0648\u062c\u0647\u06cc \u062f\u0631 GWAS \u0628\u0631\u0627\u06cc \u06a9\u0644 \u0645\u0642\u06cc\u0627\u0633 (RS10736933 \u062f\u0631 \u0646\u0632\u062f\u06cc\u06a9\u06cc ACADSB \u0648 HMX3) \u0648 \u062e\u0631\u062f\u0647 \u0645\u0642\u06cc\u0627\u0633 \u062f\u0648\u0633\u062a LSNS-6 (RS1778366 \u062f\u0631 \u0646\u0632\u062f\u06cc\u06a9\u06cc LINC02315 \u0648 LRFN5) \u0645\u0634\u062e\u0635 \u0634\u062f.\u0627\u06cc\u0646 \u0645\u0637\u0627\u0644\u0639\u0647 \u0627\u0648\u0644\u06cc\u0646 \u0634\u0648\u0627\u0647\u062f \u06af\u0633\u062a\u0631\u062f\u0647 \u0698\u0646\u0648\u0645 \u062f\u0631 \u0645\u0648\u0631\u062f \u0627\u0646\u0632\u0648\u0627\u06cc \u0627\u062c\u062a\u0645\u0627\u0639\u06cc \u062f\u0631 \u062c\u0645\u0639\u06cc\u062a \u0698\u0627\u067e\u0646 \u0631\u0627 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\u06a9\u06cc\u0641\u06cc\u062a \u062a\u0631\u062c\u0645\u0647 <\/td>\r\n \u0628\u0633\u06cc\u0627\u0631 \u0628\u0627\u0644\u0627. \u0645\u0642\u0627\u0644\u0647 \u0641\u0642\u0637 \u062a\u0648\u0633\u0637 \u0645\u062a\u0631\u062c\u0645\u06cc\u0646 \u0628\u0627 \u0645\u062f\u0631\u06a9 \u062f\u0627\u0646\u0634\u06af\u0627\u0647\u06cc \u0645\u062a\u0631\u062c\u0645\u06cc \u062a\u0631\u062c\u0645\u0647 \u0645\u06cc\u200c\u0634\u0648\u062f.<\/td>\r\n <\/tr>\r\n\t\t
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