{"id":51080,"date":"2024-12-14T13:45:31","date_gmt":"2024-12-14T13:45:31","guid":{"rendered":""},"modified":"2024-12-14T13:45:31","modified_gmt":"2024-12-14T13:45:31","slug":"%d8%aa%d8%b1%d8%ac%d9%85%d9%87-%d9%81%d8%a7%d8%b1%d8%b3%db%8c-%d9%85%d9%82%d8%a7%d9%84%d9%87-51080","status":"publish","type":"product","link":"https:\/\/express24.ir\/d\/product\/%d8%aa%d8%b1%d8%ac%d9%85%d9%87-%d9%81%d8%a7%d8%b1%d8%b3%db%8c-%d9%85%d9%82%d8%a7%d9%84%d9%87-51080\/","title":{"rendered":"\u062a\u0631\u062c\u0645\u0647 \u0641\u0627\u0631\u0633\u06cc \u0645\u0642\u0627\u0644\u0647 \u062a\u063a\u06cc\u06cc\u0631\u0627\u062a \u0631\u0641\u062a\u0627\u0631\u06cc \u062f\u0631 \u0632\u0648\u0627\u0644 \u0639\u0642\u0644 \u0641\u0631\u0648\u0646\u062a\u0648\u0645\u067e\u0648\u0631\u0627\u0644 \u0648 \u0647\u0645\u0628\u0633\u062a\u06af\u06cc \u0647\u0627\u06cc \u0634\u0646\u0627\u062e\u062a\u06cc \u0648 \u0639\u0635\u0628\u06cc \u0622\u0646\u0627\u062a\u0648\u0645\u06cc\u06a9\u06cc \u0622\u0646\u0647\u0627"},"content":{"rendered":"\n\n\n\n\n\n\n\n\n\n\n\n
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\u0639\u0646\u0648\u0627\u0646 \u0645\u0642\u0627\u0644\u0647 \u0628\u0647 \u0641\u0627\u0631\u0633\u06cc <\/td>\n\u062a\u0631\u062c\u0645\u0647 \u0641\u0627\u0631\u0633\u06cc \u0645\u0642\u0627\u0644\u0647 \u062a\u063a\u06cc\u06cc\u0631\u0627\u062a \u0631\u0641\u062a\u0627\u0631\u06cc \u062f\u0631 \u0632\u0648\u0627\u0644 \u0639\u0642\u0644 \u0641\u0631\u0648\u0646\u062a\u0648\u0645\u067e\u0648\u0631\u0627\u0644 \u0648 \u0647\u0645\u0628\u0633\u062a\u06af\u06cc \u0647\u0627\u06cc \u0634\u0646\u0627\u062e\u062a\u06cc \u0648 \u0639\u0635\u0628\u06cc \u0622\u0646\u0627\u062a\u0648\u0645\u06cc\u06a9\u06cc \u0622\u0646\u0647\u0627<\/td>\n<\/tr>\n
\u0646\u0648\u06cc\u0633\u0646\u062f\u06af\u0627\u0646 <\/td>\n ProfileMatthew A. Rouse, ProfileMasud Husain, ProfilePeter Garrard, ProfileKaralyn Patterson, ProfileJames B. Rowe, ProfileMatthew A. Lambon Ralph<\/td>\n<\/tr>\n
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\u0686\u06a9\u06cc\u062f\u0647<\/h2>\n

Behavioural changes are a central feature of frontotemporal dementia (FTD); they occur in both behavioural-variant (bvFTD) and semantic dementia (SD)\/semantic-variant primary progressive aphasia subtypes. In this study we addressed two current clinical knowledge gaps; (i) are there qualitative or clear distinctions between behavioural profiles in bvFTD and SD, and (ii) what are the precise roles of the prefrontal cortex vs. anterior temporal lobes in supporting social behaviour? Resolving these conundrums is crucial for improving diagnostic accuracy and for the development of targeted interventions to treat challenging behaviours in FTD. Informant questionnaires to assess behavioural changes included the Cambridge Behavioural Inventory-Revised and two targeted measures of apathy and impulsivity. Participants completed a detailed neuropsychological battery to permit investigation of the relationship between cognitive status (including social-semantic knowledge, general semantic processing and executive function) with behaviour change in FTD. To explore changes in regional grey matter volume, a subset of patients had structural MRI. Diagnosis-based group comparisons were supplemented by a transdiagnostic approach which encompassed the spectrum of bvFTD, SD and \u201cmixed\u201d or intermediate cases. Such an approach is sensitive to the systematic graded variation in FTD and allows the neurobiological underpinnings of behaviour change to be explored across the entire FTD spectrum. We found a wide range of behavioural changes across FTD. Although quantitatively more severe on average in bvFTD, as expected, the item-level analyses found no evidence for qualitative differences in behavioural profiles or \u201cbehavioural double dissociations\u201d between bvFTD and SD. Comparisons of self and informant ratings revealed strong discrepancies in the perspective of the caregiver vs. patient. Logistic regression revealed that neuropsychological measures had better discriminative accuracy for bvFTD vs. SD than carer-reported behavioural measures. A principal component analysis of all informant questionnaire domains extracted three components, interpreted as reflecting: (1) apathy, (2) challenging behaviours and (3) activities of daily living. More severe apathy in both FTD subtypes was associated with (a) increased levels of impaired executive function and (b) anterior cingulate cortex atrophy. Questionnaire ratings of impaired behaviour did not correlate with either anterior temporal lobe atrophy or degraded social-semantic knowledge. Together, these findings highlight the presence of a wide range of behavioural changes in both bvFTD and SD, which vary by degree rather than quality. We recommend a transdiagnostic approach for future studies of the neuropsychological and neuroanatomical underpinnings of behavioural deficits in FTD.<\/p>\n

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\u06a9\u0631\u062f\u06cc\u0645.\u0627\u06af\u0631\u0686\u0647 \u0628\u0647 \u0637\u0648\u0631 \u0645\u062a\u0648\u0633\u0637 \u200b\u200b\u062f\u0631 BVFTD \u0628\u0647 \u0637\u0648\u0631 \u0645\u062a\u0648\u0633\u0637 \u200b\u200b\u0634\u062f\u06cc\u062f\u062a\u0631 \u0627\u0633\u062a \u060c \u0647\u0645\u0627\u0646\u0637\u0648\u0631 \u06a9\u0647 \u0627\u0646\u062a\u0638\u0627\u0631 \u0645\u06cc \u0631\u0648\u062f \u060c \u062a\u062c\u0632\u06cc\u0647 \u0648 \u062a\u062d\u0644\u06cc\u0644 \u0633\u0637\u062d \u0645\u0648\u0631\u062f \u0647\u06cc\u0686 \u0645\u062f\u0631\u06a9\u06cc \u0628\u0631\u0627\u06cc \u062a\u0641\u0627\u0648\u062a \u0647\u0627\u06cc \u06a9\u06cc\u0641\u06cc \u062f\u0631 \u067e\u0631\u0648\u0641\u0627\u06cc\u0644 \u0647\u0627\u06cc \u0631\u0641\u062a\u0627\u0631\u06cc \u06cc\u0627 “\u062a\u0641\u06a9\u06cc\u06a9 \u0645\u0636\u0627\u0639\u0641 \u0631\u0641\u062a\u0627\u0631\u06cc” \u0628\u06cc\u0646 BVFTD \u0648 SD \u067e\u06cc\u062f\u0627 \u0646\u06a9\u0631\u062f.\u0645\u0642\u0627\u06cc\u0633\u0647 \u0631\u062a\u0628\u0647 \u0647\u0627\u06cc \u062e\u0648\u062f \u0648 \u0622\u06af\u0627\u0647\u0627\u0646\u0647 \u0627\u062e\u062a\u0644\u0627\u0641\u0627\u062a \u0634\u062f\u06cc\u062f\u06cc \u0631\u0627 \u062f\u0631 \u062f\u06cc\u062f\u06af\u0627\u0647 \u0645\u0631\u0627\u0642\u0628 \u062f\u0631 \u0645\u0642\u0627\u0628\u0644 \u0628\u06cc\u0645\u0627\u0631 \u0646\u0634\u0627\u0646 \u062f\u0627\u062f.\u0631\u06af\u0631\u0633\u06cc\u0648\u0646 \u0644\u062c\u0633\u062a\u06cc\u06a9 \u0646\u0634\u0627\u0646 \u062f\u0627\u062f \u06a9\u0647 \u0627\u0642\u062f\u0627\u0645\u0627\u062a \u0639\u0635\u0628\u06cc \u0631\u0648\u0627\u0646\u06cc \u0646\u0633\u0628\u062a \u0628\u0647 \u0627\u0642\u062f\u0627\u0645\u0627\u062a \u0631\u0641\u062a\u0627\u0631\u06cc \u0628\u0627 \u06af\u0632\u0627\u0631\u0634\u06af\u0631 \u060c \u0627\u0632 \u062f\u0642\u062a \u062a\u0628\u0639\u06cc\u0636 \u0622\u0645\u06cc\u0632 \u0628\u0647\u062a\u0631 \u0628\u0631\u0627\u06cc BVFTD \u062f\u0631 \u0645\u0642\u0627\u0628\u0644 SD \u0628\u0631\u062e\u0648\u0631\u062f\u0627\u0631 \u0627\u0633\u062a.\u062a\u062c\u0632\u06cc\u0647 \u0648 \u062a\u062d\u0644\u06cc\u0644 \u0645\u0624\u0644\u0641\u0647 \u0627\u0635\u0644\u06cc \u06a9\u0644\u06cc\u0647 \u062d\u0648\u0632\u0647 \u0647\u0627\u06cc \u067e\u0631\u0633\u0634\u0646\u0627\u0645\u0647 \u0622\u06af\u0627\u0647\u0627\u0646\u0647 \u0633\u0647 \u0645\u0624\u0644\u0641\u0647 \u0631\u0627 \u0627\u0633\u062a\u062e\u0631\u0627\u062c \u06a9\u0631\u062f \u060c \u06a9\u0647 \u0628\u0647 \u0639\u0646\u0648\u0627\u0646 \u0628\u0627\u0632\u062a\u0627\u0628 \u062a\u0639\u0628\u06cc\u0631 \u0645\u06cc \u0634\u0648\u062f: (1) \u0628\u06cc \u062a\u0641\u0627\u0648\u062a\u06cc \u060c (2) \u0631\u0641\u062a\u0627\u0631\u0647\u0627\u06cc \u0686\u0627\u0644\u0634 \u0628\u0631\u0627\u0646\u06af\u06cc\u0632 \u0648 (3) \u0641\u0639\u0627\u0644\u06cc\u062a \u0647\u0627\u06cc \u0632\u0646\u062f\u06af\u06cc \u0631\u0648\u0632\u0645\u0631\u0647.\u0628\u06cc \u062a\u0641\u0627\u0648\u062a\u06cc \u0634\u062f\u06cc\u062f\u062a\u0631 \u062f\u0631 \u0647\u0631 \u062f\u0648 \u0632\u06cc\u0631\u06af\u0631\u0648\u0647 FTD \u0628\u0627 (\u0627\u0644\u0641) \u0627\u0641\u0632\u0627\u06cc\u0634 \u0633\u0637\u062d \u0639\u0645\u0644\u06a9\u0631\u062f \u0627\u062c\u0631\u0627\u06cc\u06cc \u0627\u062e\u062a\u0644\u0627\u0644 \u0648 (\u0628) \u0622\u062a\u0631\u0648\u0641\u06cc \u0642\u0634\u0631 \u0633\u06cc\u0646\u06af\u0648\u0644\u0627\u0633\u06cc\u0648\u0646 \u0642\u062f\u0627\u0645\u06cc \u0647\u0645\u0631\u0627\u0647 \u0628\u0648\u062f.\u0631\u062a\u0628\u0647 \u0628\u0646\u062f\u06cc \u067e\u0631\u0633\u0634\u0646\u0627\u0645\u0647 \u0627\u0632 \u0631\u0641\u062a\u0627\u0631 \u0627\u062e\u062a\u0644\u0627\u0644 \u0628\u0627 \u0622\u062a\u0631\u0648\u0641\u06cc \u0644\u0648\u0628 \u062a\u0645\u067e\u0648\u0631\u0627\u0644 \u0642\u062f\u0627\u0645\u06cc \u06cc\u0627 \u062f\u0627\u0646\u0634 \u0627\u062c\u062a\u0645\u0627\u0639\u06cc-\u0645\u0639\u0646\u0627\u06cc\u06cc \u062a\u062e\u0631\u06cc\u0628 \u0634\u062f\u0647 \u0627\u0631\u062a\u0628\u0627\u0637 \u0646\u062f\u0627\u0631\u062f.\u0628\u0627 \u0647\u0645 \u060c \u0627\u06cc\u0646 \u06cc\u0627\u0641\u062a\u0647 \u0647\u0627 \u0648\u062c\u0648\u062f \u0637\u06cc\u0641 \u06af\u0633\u062a\u0631\u062f\u0647 \u0627\u06cc \u0627\u0632 \u062a\u063a\u06cc\u06cc\u0631\u0627\u062a \u0631\u0641\u062a\u0627\u0631\u06cc \u062f\u0631 BVFTD \u0648 SD \u0631\u0627 \u0628\u0631\u062c\u0633\u062a\u0647 \u0645\u06cc \u06a9\u0646\u062f \u060c \u06a9\u0647 \u0628\u0647 \u062c\u0627\u06cc \u06a9\u06cc\u0641\u06cc\u062a \u0627\u0632 \u0646\u0638\u0631 \u062f\u0631\u062c\u0647 \u0645\u062a\u0641\u0627\u0648\u062a \u0647\u0633\u062a\u0646\u062f.\u0645\u0627 \u06cc\u06a9 \u0631\u0648\u0634 transdiagnostic \u0631\u0627 \u0628\u0631\u0627\u06cc \u0645\u0637\u0627\u0644\u0639\u0627\u062a \u0622\u06cc\u0646\u062f\u0647 \u062f\u0631 \u0645\u0648\u0631\u062f \u0632\u06cc\u0631\u0628\u0646\u0627\u06cc \u0639\u0635\u0628\u06cc \u0631\u0648\u0627\u0646\u06cc \u0648 \u0639\u0635\u0628\u06cc \u0627\u0632 \u0646\u0642\u0635 \u0631\u0641\u062a\u0627\u0631\u06cc \u062f\u0631 FTD \u062a\u0648\u0635\u06cc\u0647 \u0645\u06cc \u06a9\u0646\u06cc\u0645.<\/p>\n\r\n\r\n \r\n \r\n \r\n \r\n
\u0641\u0631\u0645\u062a \u0627\u0631\u0627\u0626\u0647 \u062a\u0631\u062c\u0645\u0647 \u0645\u0642\u0627\u0644\u0647 <\/td>\r\n \u062a\u062d\u0648\u06cc\u0644 \u0628\u0647 \u0635\u0648\u0631\u062a \u0641\u0627\u06cc\u0644 \u0648\u0631\u062f<\/td>\r\n <\/tr>\r\n
\u0632\u0645\u0627\u0646 \u062a\u062d\u0648\u06cc\u0644 \u062a\u0631\u062c\u0645\u0647 \u0645\u0642\u0627\u0644\u0647 <\/td>\r\n \u0628\u06cc\u0646 2 \u062a\u0627 3 \u0631\u0648\u0632 \u067e\u0633 \u0627\u0632 \u062b\u0628\u062a \u0633\u0641\u0627\u0631\u0634<\/td>\r\n <\/tr>\r\n\t
\u06a9\u06cc\u0641\u06cc\u062a \u062a\u0631\u062c\u0645\u0647 <\/td>\r\n \u0628\u0633\u06cc\u0627\u0631 \u0628\u0627\u0644\u0627. \u0645\u0642\u0627\u0644\u0647 \u0641\u0642\u0637 \u062a\u0648\u0633\u0637 \u0645\u062a\u0631\u062c\u0645\u06cc\u0646 \u0628\u0627 \u0645\u062f\u0631\u06a9 \u062f\u0627\u0646\u0634\u06af\u0627\u0647\u06cc \u0645\u062a\u0631\u062c\u0645\u06cc \u062a\u0631\u062c\u0645\u0647 \u0645\u06cc\u200c\u0634\u0648\u062f.<\/td>\r\n <\/tr>\r\n\t\t
\u062c\u062f\u0627\u0648\u0644 \u0648 \u0641\u0631\u0645\u0648\u0644 \u0647\u0627 <\/td>\r\n \u06a9\u0644\u06cc\u0647 \u062c\u062f\u0627\u0648\u0644 \u0648 \u0641\u0631\u0645\u0648\u0644 \u0647\u0627 \u0646\u06cc\u0632 \u062f\u0631 \u0641\u0627\u06cc\u0644 \u062a\u062d\u0648\u06cc\u0644\u06cc \u0648\u0631\u062f \u062f\u0631\u062c \u0645\u06cc\u200c\u0634\u0648\u0646\u062f.<\/td>\r\n <\/tr>\r\n<\/table>\r\n\r\n\n","protected":false},"excerpt":{"rendered":"

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