{"id":50965,"date":"2024-12-11T14:48:03","date_gmt":"2024-12-11T14:48:03","guid":{"rendered":""},"modified":"2024-12-11T14:48:03","modified_gmt":"2024-12-11T14:48:03","slug":"%d8%aa%d8%b1%d8%ac%d9%85%d9%87-%d9%81%d8%a7%d8%b1%d8%b3%db%8c-%d9%85%d9%82%d8%a7%d9%84%d9%87-50965","status":"publish","type":"product","link":"https:\/\/express24.ir\/d\/product\/%d8%aa%d8%b1%d8%ac%d9%85%d9%87-%d9%81%d8%a7%d8%b1%d8%b3%db%8c-%d9%85%d9%82%d8%a7%d9%84%d9%87-50965\/","title":{"rendered":"\u062a\u0631\u062c\u0645\u0647 \u0641\u0627\u0631\u0633\u06cc \u0645\u0642\u0627\u0644\u0647 \u0627\u0632 \u062f\u0633\u062a \u062f\u0627\u062f\u0646 \u0639\u0645\u0644\u06a9\u0631\u062f \u067e\u0631\u0648\u062a\u0626\u06cc\u0646 \u0645\u062a\u0635\u0644 \u0634\u0648\u0646\u062f\u0647 \u0628\u0647 RNA PRRC2B \u0628\u0627\u0639\u062b \u0646\u0642\u0635 \u062a\u0631\u062c\u0645\u0647 \u0648 \u0646\u0627\u0647\u0646\u062c\u0627\u0631\u06cc \u0645\u0627\u062f\u0631\u0632\u0627\u062f\u06cc \u0642\u0644\u0628\u06cc \u0639\u0631\u0648\u0642\u06cc \u0645\u06cc \u0634\u0648\u062f."},"content":{"rendered":"\n\n\n\n\n\n\n\n\n\n\n\n
\u0639\u0646\u0648\u0627\u0646 \u0645\u0642\u0627\u0644\u0647 \u0628\u0647 \u0627\u0646\u06af\u0644\u06cc\u0633\u06cc <\/td>\nLoss-of-function of RNA-binding protein PRRC2B causes translational defects and congenital cardiovascular malformation<\/td>\n<\/tr>\n
\u0639\u0646\u0648\u0627\u0646 \u0645\u0642\u0627\u0644\u0647 \u0628\u0647 \u0641\u0627\u0631\u0633\u06cc <\/td>\n\u062a\u0631\u062c\u0645\u0647 \u0641\u0627\u0631\u0633\u06cc \u0645\u0642\u0627\u0644\u0647 \u0627\u0632 \u062f\u0633\u062a \u062f\u0627\u062f\u0646 \u0639\u0645\u0644\u06a9\u0631\u062f \u067e\u0631\u0648\u062a\u0626\u06cc\u0646 \u0645\u062a\u0635\u0644 \u0634\u0648\u0646\u062f\u0647 \u0628\u0647 RNA PRRC2B \u0628\u0627\u0639\u062b \u0646\u0642\u0635 \u062a\u0631\u062c\u0645\u0647 \u0648 \u0646\u0627\u0647\u0646\u062c\u0627\u0631\u06cc \u0645\u0627\u062f\u0631\u0632\u0627\u062f\u06cc \u0642\u0644\u0628\u06cc \u0639\u0631\u0648\u0642\u06cc \u0645\u06cc \u0634\u0648\u062f.<\/td>\n<\/tr>\n
\u0646\u0648\u06cc\u0633\u0646\u062f\u06af\u0627\u0646 <\/td>\nDebojyoti Das, Eng-Soon Khor, Feng Jiang, Jiali He, Yui Kawakami, Lindsey Wainwright, Jared Hollinger, Joshua Geiger, Huan Liu, Fanju Meng, George A. Porter Jr., Zhenggen Jin, ProfilePatrick Murphy, Peng Yao<\/td>\n<\/tr>\n
\u0641\u0631\u0645\u062a \u0645\u0642\u0627\u0644\u0647 \u0627\u0646\u06af\u0644\u06cc\u0633\u06cc <\/td>\nPDF<\/td>\n<\/tr>\n
\u0632\u0628\u0627\u0646 \u0645\u0642\u0627\u0644\u0647 \u062a\u062d\u0648\u06cc\u0644\u06cc <\/td>\n\u062a\u0631\u062c\u0645\u0647 \u0641\u0627\u0631\u0633\u06cc<\/td>\n<\/tr>\n
\u0641\u0631\u0645\u062a \u0645\u0642\u0627\u0644\u0647 \u062a\u0631\u062c\u0645\u0647 \u0634\u062f\u0647 <\/td>\n\u0628\u0647 \u0635\u0648\u0631\u062a \u0641\u0627\u06cc\u0644 \u0648\u0631\u062f<\/td>\n<\/tr>\n
\u0646\u062d\u0648\u0647 \u062a\u062d\u0648\u06cc\u0644 \u062a\u0631\u062c\u0645\u0647 <\/td>\n\u062f\u0648 \u062a\u0627 \u0633\u0647 \u0631\u0648\u0632 \u067e\u0633 \u0627\u0632 \u062b\u0628\u062a \u0633\u0641\u0627\u0631\u0634 (\u0628\u0647 \u0635\u0648\u0631\u062a \u0641\u0627\u06cc\u0644 \u062f\u0627\u0646\u0644\u0648\u062f\u06cc)<\/td>\n<\/tr>\n
\u062a\u0639\u062f\u0627\u062f \u0635\u0641\u062d\u0627\u062a<\/td>\n56<\/td>\n<\/tr>\n
\u0644\u06cc\u0646\u06a9 \u062f\u0627\u0646\u0644\u0648\u062f \u0631\u0627\u06cc\u06af\u0627\u0646 \u0645\u0642\u0627\u0644\u0647 \u0627\u0646\u06af\u0644\u06cc\u0633\u06cc<\/td>\n\u062f\u0627\u0646\u0644\u0648\u062f \u0645\u0642\u0627\u0644\u0647<\/a><\/td>\n<\/tr>\n
\u062f\u0633\u062a\u0647 \u0628\u0646\u062f\u06cc \u0645\u0648\u0636\u0648\u0639\u0627\u062a <\/td>\nCardiovascular Medicine
\n\u062f\u0627\u0631\u0648\u0647\u0627\u06cc \u0639\u0631\u0648\u0642\u06cc<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\r\n\r\n \r\n \r\n \r\n \r\n
\u0641\u0631\u0645\u062a \u0627\u0631\u0627\u0626\u0647 \u062a\u0631\u062c\u0645\u0647 \u0645\u0642\u0627\u0644\u0647 <\/td>\r\n \u062a\u062d\u0648\u06cc\u0644 \u0628\u0647 \u0635\u0648\u0631\u062a \u0641\u0627\u06cc\u0644 \u0648\u0631\u062f<\/td>\r\n <\/tr>\r\n
\u0632\u0645\u0627\u0646 \u062a\u062d\u0648\u06cc\u0644 \u062a\u0631\u062c\u0645\u0647 \u0645\u0642\u0627\u0644\u0647 <\/td>\r\n \u0628\u06cc\u0646 2 \u062a\u0627 3 \u0631\u0648\u0632 \u067e\u0633 \u0627\u0632 \u062b\u0628\u062a \u0633\u0641\u0627\u0631\u0634<\/td>\r\n <\/tr>\r\n\t
\u06a9\u06cc\u0641\u06cc\u062a \u062a\u0631\u062c\u0645\u0647 <\/td>\r\n \u0628\u0633\u06cc\u0627\u0631 \u0628\u0627\u0644\u0627. \u0645\u0642\u0627\u0644\u0647 \u0641\u0642\u0637 \u062a\u0648\u0633\u0637 \u0645\u062a\u0631\u062c\u0645\u06cc\u0646 \u0628\u0627 \u0645\u062f\u0631\u06a9 \u062f\u0627\u0646\u0634\u06af\u0627\u0647\u06cc \u0645\u062a\u0631\u062c\u0645\u06cc \u062a\u0631\u062c\u0645\u0647 \u0645\u06cc\u200c\u0634\u0648\u062f.<\/td>\r\n <\/tr>\r\n\t\t
\u062c\u062f\u0627\u0648\u0644 \u0648 \u0641\u0631\u0645\u0648\u0644 \u0647\u0627 <\/td>\r\n \u06a9\u0644\u06cc\u0647 \u062c\u062f\u0627\u0648\u0644 \u0648 \u0641\u0631\u0645\u0648\u0644 \u0647\u0627 \u0646\u06cc\u0632 \u062f\u0631 \u0641\u0627\u06cc\u0644 \u062a\u062d\u0648\u06cc\u0644\u06cc \u0648\u0631\u062f \u062f\u0631\u062c \u0645\u06cc\u200c\u0634\u0648\u0646\u062f.<\/td>\r\n <\/tr>\r\n<\/table>\r\n\r\n\n

\u0686\u06a9\u06cc\u062f\u0647<\/h2>\n

Alternative splicing generates variant forms of proteins for a given gene and accounts for functional redundancy or diversification. A novel RNA-binding protein, Pro-rich Coiled-coil Containing Protein 2B (PRRC2B), has been reported by multiple laboratories to mediate uORF-dependent and independent regulation of translation initiation required for cell cycle progression and proliferation. We identified two alternative spliced isoforms in human and mouse hearts and HEK293T cells, full-length (FL) and exon 16-excluded isoform \u0394E16. A congenital heart disease-associated human mutation-mimicry knock-in of the equivalent variant in the mouse genome leads to the depletion of the full-length Prrc2b mRNA but not the alternative spliced truncated form \u0394E16, does not cause any apparent structural or functional disorders. In contrast, global genetic inactivation of the PRRC2B gene in the mouse genome, nullifying both mRNA isoforms, caused patent ductus arteriosus (PDA) and neonatal lethality in mice. Bulk and single nucleus transcriptome profiling analyses of embryonic mouse hearts demonstrated a significant overall downregulation of multiple smooth muscle-specific genes in Prrc2b mutant mice resulting from reduced smooth muscle cell number. Integrated analysis of proteomic changes in Prrc2b null mouse embryonic hearts and polysome-seq and RNA-seq multi-omics analysis in human HEK293T cells uncover conserved PRRC2B-regulated target mRNAs that encode essential factors required for cardiac and vascular development. Our findings reveal the connection between alternative splicing regulation of PRRC2B, PRRC2B-mediated translational control, and congenital cardiovascular development and disorder. This study may shed light on the significance of PRRC2B in human cardiovascular disease diagnosis and treatment.<\/p>\n

\u0686\u06a9\u06cc\u062f\u0647 \u0628\u0647 \u0641\u0627\u0631\u0633\u06cc (\u062a\u0631\u062c\u0645\u0647 \u0645\u0627\u0634\u06cc\u0646\u06cc)<\/h2>\n

\u062a\u0631\u06a9\u06cc\u0628\u06cc \u062c\u0627\u06cc\u06af\u0632\u06cc\u0646 \u0627\u0634\u06a9\u0627\u0644 \u0645\u062e\u062a\u0644\u0641 \u067e\u0631\u0648\u062a\u0626\u06cc\u0646 \u0647\u0627 \u0631\u0627 \u0628\u0631\u0627\u06cc \u06cc\u06a9 \u0698\u0646 \u062e\u0627\u0635 \u0627\u06cc\u062c\u0627\u062f \u0645\u06cc \u06a9\u0646\u062f \u0648 \u0628\u0631\u0627\u06cc \u0627\u0641\u0632\u0648\u0646\u06af\u06cc \u0639\u0645\u0644\u06a9\u0631\u062f\u06cc \u06cc\u0627 \u062a\u0646\u0648\u0639 \u0639\u0645\u0644\u06a9\u0631\u062f\u06cc \u0631\u0627 \u062a\u0634\u06a9\u06cc\u0644 \u0645\u06cc \u062f\u0647\u062f.\u06cc\u06a9 \u067e\u0631\u0648\u062a\u0626\u06cc\u0646 \u0627\u062a\u0635\u0627\u0644 \u062f\u0647\u0646\u062f\u0647 RNA \u062c\u062f\u06cc\u062f \u060c \u0633\u06cc\u0645 \u067e\u06cc\u0686 \u0648 \u062e\u0645\u06cc\u062f\u0647 \u062d\u0627\u0648\u06cc \u067e\u0631\u0648\u062a\u0626\u06cc\u0646 2B (PRRC2B) \u060c \u062a\u0648\u0633\u0637 \u0622\u0632\u0645\u0627\u06cc\u0634\u06af\u0627\u0647 \u0647\u0627\u06cc \u0645\u062a\u0639\u062f\u062f \u06af\u0632\u0627\u0631\u0634 \u0634\u062f\u0647 \u0627\u0633\u062a \u062a\u0627 \u0648\u0627\u0633\u0637\u0647 \u062a\u0646\u0638\u06cc\u0645 \u0648\u0627\u0628\u0633\u062a\u0647 \u0628\u0647 UORF \u0648 \u0645\u0633\u062a\u0642\u0644 \u0627\u0632 \u0634\u0631\u0648\u0639 \u062a\u0631\u062c\u0645\u0647 \u0645\u0648\u0631\u062f \u0646\u06cc\u0627\u0632 \u0628\u0631\u0627\u06cc \u067e\u06cc\u0634\u0631\u0641\u062a \u0648 \u062a\u06a9\u062b\u06cc\u0631 \u0686\u0631\u062e\u0647 \u0633\u0644\u0648\u0644\u06cc \u0628\u0627\u0634\u062f.\u0645\u0627 \u062f\u0648 \u0627\u06cc\u0632\u0648\u0641\u0631\u0645 \u0634\u06a9\u0627\u0641 \u062c\u0627\u06cc\u06af\u0632\u06cc\u0646 \u062f\u0631 \u0642\u0644\u0628 \u0627\u0646\u0633\u0627\u0646 \u0648 \u0645\u0648\u0634 \u0648 \u0633\u0644\u0648\u0644\u0647\u0627\u06cc HEK293T \u060c \u062a\u0645\u0627\u0645 \u0637\u0648\u0644 (FL) \u0648 \u0627\u06cc\u0632\u0648\u0641\u0631\u0645 16-5- \u0628\u0647 \u0648\u062c\u0648\u062f \u0622\u0645\u062f\u0647 \u0627\u0632 \u0627\u06af\u0632\u0648\u0646 \u0631\u0627 \u0634\u0646\u0627\u0633\u0627\u06cc\u06cc \u06a9\u0631\u062f\u06cc\u0645.\u0636\u0631\u0628 \u0648 \u0634\u062a\u0645 \u0648 \u062a\u0642\u0644\u06cc\u062f \u0627\u0632 \u062c\u0647\u0634 \u0628\u0647 \u0628\u06cc\u0645\u0627\u0631\u06cc \u0642\u0644\u0628\u06cc \u0645\u0627\u062f\u0631\u0632\u0627\u062f\u06cc \u0627\u0632 \u0646\u0648\u0639 \u0645\u0639\u0627\u062f\u0644 \u0622\u0646 \u062f\u0631 \u0698\u0646\u0648\u0645 \u0645\u0648\u0634 \u0645\u0646\u062c\u0631 \u0628\u0647 \u06a9\u0627\u0647\u0634 mRNA \u0698\u0646 PRRC2B \u062a\u0645\u0627\u0645 \u0637\u0648\u0644 \u0645\u06cc \u0634\u0648\u062f \u0627\u0645\u0627 \u0641\u0631\u0645 \u06a9\u0648\u062a\u0627\u0647 \u0634\u062f\u0647 \u0627\u06cc \u062c\u0627\u06cc\u06af\u0632\u06cc\u0646 \u0394E16 \u0646\u06cc\u0633\u062a \u060c \u0628\u0627\u0639\u062b \u0627\u06cc\u062c\u0627\u062f \u0647\u06cc\u0686 \u06af\u0648\u0646\u0647 \u0627\u062e\u062a\u0644\u0627\u0644 \u062f\u0631 \u0633\u0627\u062e\u062a\u0627\u0631\u06cc \u06cc\u0627 \u0639\u0645\u0644\u06a9\u0631\u062f\u06cc \u0646\u0645\u06cc \u0634\u0648\u062f\u0628\u0634\u0631\u062f\u0631 \u0645\u0642\u0627\u0628\u0644 \u060c \u063a\u06cc\u0631\u0641\u0639\u0627\u0644 \u0633\u0627\u0632\u06cc \u0698\u0646\u062a\u06cc\u06a9\u06cc \u062c\u0647\u0627\u0646\u06cc \u0698\u0646 prrc2b \u062f\u0631 \u0698\u0646\u0648\u0645 \u0645\u0648\u0634 \u060c \u0647\u0631 \u062f\u0648 \u0627\u06cc\u0632\u0648\u0641\u0631\u0645 mRNA \u0631\u0627 \u0628\u0627\u0637\u0644 \u0645\u06cc \u06a9\u0646\u062f \u060c \u0628\u0627\u0639\u062b \u0627\u06cc\u062c\u0627\u062f \u062d\u0642 \u062b\u0628\u062a \u0627\u062e\u062a\u0631\u0627\u0639 \u0634\u0631\u06cc\u0627\u0646\u06cc (PDA) \u0648 \u0645\u0631\u06af \u0648 \u0645\u06cc\u0631 \u0646\u0648\u0632\u0627\u062f\u0627\u0646 \u062f\u0631 \u0645\u0648\u0634 \u0647\u0627 \u0645\u06cc \u0634\u0648\u062f.\u062a\u062c\u0632\u06cc\u0647 \u0648 \u062a\u062d\u0644\u06cc\u0644 \u067e\u0631\u0648\u0641\u0627\u06cc\u0644 \u0631\u0648\u0646\u0648\u0634\u062a \u0641\u0644\u0647 \u0648 \u062a\u06a9 \u0647\u0633\u062a\u0647 \u0627\u06cc \u0627\u0632 \u0642\u0644\u0628 \u0645\u0627\u0648\u0633 \u062c\u0646\u06cc\u0646\u06cc \u060c \u0645\u0647\u0627\u0631 \u06a9\u0644\u06cc \u0642\u0627\u0628\u0644 \u062a\u0648\u062c\u0647\u06cc \u0627\u0632 \u0698\u0646\u0647\u0627\u06cc \u062e\u0627\u0635 \u0639\u0636\u0644\u0627\u062a \u0635\u0627\u0641 \u062f\u0631 \u0645\u0648\u0634 \u0647\u0627\u06cc \u062c\u0647\u0634 \u06cc\u0627\u0641\u062a\u0647 PRRC2B \u0631\u0627 \u0646\u0634\u0627\u0646 \u0645\u06cc \u062f\u0647\u062f \u06a9\u0647 \u0646\u0627\u0634\u06cc \u0627\u0632 \u06a9\u0627\u0647\u0634 \u062a\u0639\u062f\u0627\u062f \u0633\u0644\u0648\u0644 \u0647\u0627\u06cc \u0639\u0636\u0644\u0627\u0646\u06cc \u0635\u0627\u0641 \u0627\u0633\u062a.\u062a\u062c\u0632\u06cc\u0647 \u0648 \u062a\u062d\u0644\u06cc\u0644 \u06cc\u06a9\u067e\u0627\u0631\u0686\u0647 \u0627\u0632 \u062a\u063a\u06cc\u06cc\u0631\u0627\u062a \u067e\u0631\u0648\u062a\u0626\u0648\u0645\u06cc\u06a9 \u062f\u0631 \u0642\u0644\u0628 \u0647\u0627\u06cc \u062c\u0646\u06cc\u0646\u06cc \u0645\u0648\u0634 \u062a\u0647\u06cc PRRC2B \u0648 \u062a\u062c\u0632\u06cc\u0647 \u0648 \u062a\u062d\u0644\u06cc\u0644 \u0686\u0646\u062f\u0645\u06cc\u06a9 Polysome-Seq \u0648 RNA-SEQ \u062f\u0631 \u0633\u0644\u0648\u0644\u0647\u0627\u06cc HEK293T \u0627\u0646\u0633\u0627\u0646 \u0627\u0632 mRNA \u0647\u0627\u06cc \u0647\u062f\u0641 \u062a\u0646\u0638\u06cc\u0645 \u0634\u062f\u0647 PRRC2B \u0645\u062d\u0627\u0641\u0638\u062a \u0645\u06cc \u0634\u0648\u062f \u06a9\u0647 \u0639\u0648\u0627\u0645\u0644 \u0627\u0633\u0627\u0633\u06cc \u0645\u0648\u0631\u062f \u0646\u06cc\u0627\u0632 \u0628\u0631\u0627\u06cc \u0631\u0634\u062f \u0642\u0644\u0628\u06cc \u0648 \u0639\u0631\u0648\u0642\u06cc \u0631\u0627 \u0631\u0645\u0632\u06af\u0630\u0627\u0631\u06cc \u0645\u06cc \u06a9\u0646\u0646\u062f.\u06cc\u0627\u0641\u062a\u0647 \u0647\u0627\u06cc \u0645\u0627 \u0627\u0631\u062a\u0628\u0627\u0637 \u0628\u06cc\u0646 \u062a\u0646\u0638\u06cc\u0645 \u062a\u0631\u06a9\u06cc\u0628\u06cc \u062c\u0627\u06cc\u06af\u0632\u06cc\u0646 PRRC2B \u060c \u06a9\u0646\u062a\u0631\u0644 \u062a\u0631\u062c\u0645\u0647 \u062a\u0631\u062c\u0645\u0647 \u0628\u0627 \u0648\u0627\u0633\u0637\u0647 PRRC2B \u0648 \u0631\u0634\u062f \u0648 \u0627\u062e\u062a\u0644\u0627\u0644 \u0642\u0644\u0628\u06cc \u0639\u0631\u0648\u0642\u06cc \u0645\u0627\u062f\u0631\u0632\u0627\u062f\u06cc \u0631\u0627 \u0646\u0634\u0627\u0646 \u0645\u06cc \u062f\u0647\u062f.\u0627\u06cc\u0646 \u0645\u0637\u0627\u0644\u0639\u0647 \u0645\u0645\u06a9\u0646 \u0627\u0633\u062a \u0627\u0647\u0645\u06cc\u062a PRRC2B \u0631\u0627 \u062f\u0631 \u062a\u0634\u062e\u06cc\u0635 \u0648 \u062f\u0631\u0645\u0627\u0646 \u0628\u06cc\u0645\u0627\u0631\u06cc \u0647\u0627\u06cc \u0642\u0644\u0628\u06cc \u0639\u0631\u0648\u0642\u06cc \u0627\u0646\u0633\u0627\u0646 \u0631\u0648\u0634\u0646 \u06a9\u0646\u062f.<\/p>\n\r\n\r\n \r\n \r\n \r\n \r\n
\u0641\u0631\u0645\u062a \u0627\u0631\u0627\u0626\u0647 \u062a\u0631\u062c\u0645\u0647 \u0645\u0642\u0627\u0644\u0647 <\/td>\r\n \u062a\u062d\u0648\u06cc\u0644 \u0628\u0647 \u0635\u0648\u0631\u062a \u0641\u0627\u06cc\u0644 \u0648\u0631\u062f<\/td>\r\n <\/tr>\r\n
\u0632\u0645\u0627\u0646 \u062a\u062d\u0648\u06cc\u0644 \u062a\u0631\u062c\u0645\u0647 \u0645\u0642\u0627\u0644\u0647 <\/td>\r\n \u0628\u06cc\u0646 2 \u062a\u0627 3 \u0631\u0648\u0632 \u067e\u0633 \u0627\u0632 \u062b\u0628\u062a \u0633\u0641\u0627\u0631\u0634<\/td>\r\n <\/tr>\r\n\t
\u06a9\u06cc\u0641\u06cc\u062a \u062a\u0631\u062c\u0645\u0647 <\/td>\r\n \u0628\u0633\u06cc\u0627\u0631 \u0628\u0627\u0644\u0627. \u0645\u0642\u0627\u0644\u0647 \u0641\u0642\u0637 \u062a\u0648\u0633\u0637 \u0645\u062a\u0631\u062c\u0645\u06cc\u0646 \u0628\u0627 \u0645\u062f\u0631\u06a9 \u062f\u0627\u0646\u0634\u06af\u0627\u0647\u06cc \u0645\u062a\u0631\u062c\u0645\u06cc \u062a\u0631\u062c\u0645\u0647 \u0645\u06cc\u200c\u0634\u0648\u062f.<\/td>\r\n <\/tr>\r\n\t\t
\u062c\u062f\u0627\u0648\u0644 \u0648 \u0641\u0631\u0645\u0648\u0644 \u0647\u0627 <\/td>\r\n \u06a9\u0644\u06cc\u0647 \u062c\u062f\u0627\u0648\u0644 \u0648 \u0641\u0631\u0645\u0648\u0644 \u0647\u0627 \u0646\u06cc\u0632 \u062f\u0631 \u0641\u0627\u06cc\u0644 \u062a\u062d\u0648\u06cc\u0644\u06cc \u0648\u0631\u062f \u062f\u0631\u062c \u0645\u06cc\u200c\u0634\u0648\u0646\u062f.<\/td>\r\n <\/tr>\r\n<\/table>\r\n\r\n\n","protected":false},"excerpt":{"rendered":"

\u0639\u0646\u0648\u0627\u0646 \u0645\u0642\u0627\u0644\u0647 \u0628\u0647 \u0627\u0646\u06af\u0644\u06cc\u0633\u06cc Loss-of-function of RNA-binding protein PRRC2B causes translational defects and congenital cardiovascular malformation \u0639\u0646\u0648\u0627\u0646 \u0645\u0642\u0627\u0644\u0647 \u0628\u0647 \u0641\u0627\u0631\u0633\u06cc […]<\/p>\n","protected":false},"featured_media":27,"comment_status":"open","ping_status":"open","template":"","meta":{"pmpro_default_level":"","site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}}},"product_cat":[21],"product_tag":[],"class_list":{"0":"post-50965","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-21","7":"pmpro-has-access","8":"desktop-align-left","9":"tablet-align-left","10":"mobile-align-left","12":"first","13":"instock","14":"downloadable","15":"shipping-taxable","16":"purchasable","17":"product-type-simple"},"yoast_head":"\n\u062a\u0631\u062c\u0645\u0647 \u0641\u0627\u0631\u0633\u06cc \u0645\u0642\u0627\u0644\u0647 \u0627\u0632 \u062f\u0633\u062a \u062f\u0627\u062f\u0646 \u0639\u0645\u0644\u06a9\u0631\u062f \u067e\u0631\u0648\u062a\u0626\u06cc\u0646 \u0645\u062a\u0635\u0644 \u0634\u0648\u0646\u062f\u0647 \u0628\u0647 RNA PRRC2B \u0628\u0627\u0639\u062b \u0646\u0642\u0635 \u062a\u0631\u062c\u0645\u0647 \u0648 \u0646\u0627\u0647\u0646\u062c\u0627\u0631\u06cc \u0645\u0627\u062f\u0631\u0632\u0627\u062f\u06cc \u0642\u0644\u0628\u06cc \u0639\u0631\u0648\u0642\u06cc \u0645\u06cc \u0634\u0648\u062f. - \u0641\u0631\u0648\u0634\u06af\u0627\u0647 \u0627\u06a9\u0633\u067e\u0631\u0633<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/express24.ir\/d\/product\/\u062a\u0631\u062c\u0645\u0647-\u0641\u0627\u0631\u0633\u06cc-\u0645\u0642\u0627\u0644\u0647-50965\/\" \/>\n<meta property=\"og:locale\" content=\"fa_IR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u062a\u0631\u062c\u0645\u0647 \u0641\u0627\u0631\u0633\u06cc \u0645\u0642\u0627\u0644\u0647 \u0627\u0632 \u062f\u0633\u062a \u062f\u0627\u062f\u0646 \u0639\u0645\u0644\u06a9\u0631\u062f \u067e\u0631\u0648\u062a\u0626\u06cc\u0646 \u0645\u062a\u0635\u0644 \u0634\u0648\u0646\u062f\u0647 \u0628\u0647 RNA PRRC2B \u0628\u0627\u0639\u062b \u0646\u0642\u0635 \u062a\u0631\u062c\u0645\u0647 \u0648 \u0646\u0627\u0647\u0646\u062c\u0627\u0631\u06cc \u0645\u0627\u062f\u0631\u0632\u0627\u062f\u06cc \u0642\u0644\u0628\u06cc \u0639\u0631\u0648\u0642\u06cc \u0645\u06cc \u0634\u0648\u062f. - \u0641\u0631\u0648\u0634\u06af\u0627\u0647 \u0627\u06a9\u0633\u067e\u0631\u0633\" \/>\n<meta property=\"og:description\" content=\"\u0639\u0646\u0648\u0627\u0646 \u0645\u0642\u0627\u0644\u0647 \u0628\u0647 \u0627\u0646\u06af\u0644\u06cc\u0633\u06cc Loss-of-function of RNA-binding protein PRRC2B causes translational defects and congenital cardiovascular malformation \u0639\u0646\u0648\u0627\u0646 \u0645\u0642\u0627\u0644\u0647 \u0628\u0647 \u0641\u0627\u0631\u0633\u06cc […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/express24.ir\/d\/product\/\u062a\u0631\u062c\u0645\u0647-\u0641\u0627\u0631\u0633\u06cc-\u0645\u0642\u0627\u0644\u0647-50965\/\" \/>\n<meta property=\"og:site_name\" content=\"\u0641\u0631\u0648\u0634\u06af\u0627\u0647 \u0627\u06a9\u0633\u067e\u0631\u0633\" \/>\n<meta property=\"og:image\" content=\"https:\/\/express24.ir\/d\/wp-content\/uploads\/2024\/02\/Elsevier_logo_2019.svg_.png\" \/>\n\t<meta property=\"og:image:width\" content=\"440\" \/>\n\t<meta property=\"og:image:height\" content=\"486\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"\u0632\u0645\u0627\u0646 \u062a\u0642\u0631\u06cc\u0628\u06cc \u0628\u0631\u0627\u06cc \u062e\u0648\u0627\u0646\u062f\u0646\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 \u062f\u0642\u06cc\u0642\u0647\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/express24.ir\/d\/product\/%d8%aa%d8%b1%d8%ac%d9%85%d9%87-%d9%81%d8%a7%d8%b1%d8%b3%db%8c-%d9%85%d9%82%d8%a7%d9%84%d9%87-50965\/\",\"url\":\"https:\/\/express24.ir\/d\/product\/%d8%aa%d8%b1%d8%ac%d9%85%d9%87-%d9%81%d8%a7%d8%b1%d8%b3%db%8c-%d9%85%d9%82%d8%a7%d9%84%d9%87-50965\/\",\"name\":\"\u062a\u0631\u062c\u0645\u0647 \u0641\u0627\u0631\u0633\u06cc \u0645\u0642\u0627\u0644\u0647 \u0627\u0632 \u062f\u0633\u062a \u062f\u0627\u062f\u0646 \u0639\u0645\u0644\u06a9\u0631\u062f \u067e\u0631\u0648\u062a\u0626\u06cc\u0646 \u0645\u062a\u0635\u0644 \u0634\u0648\u0646\u062f\u0647 \u0628\u0647 RNA PRRC2B \u0628\u0627\u0639\u062b \u0646\u0642\u0635 \u062a\u0631\u062c\u0645\u0647 \u0648 \u0646\u0627\u0647\u0646\u062c\u0627\u0631\u06cc \u0645\u0627\u062f\u0631\u0632\u0627\u062f\u06cc \u0642\u0644\u0628\u06cc \u0639\u0631\u0648\u0642\u06cc \u0645\u06cc \u0634\u0648\u062f. - \u0641\u0631\u0648\u0634\u06af\u0627\u0647 \u0627\u06a9\u0633\u067e\u0631\u0633\",\"isPartOf\":{\"@id\":\"https:\/\/express24.ir\/d\/#website\"},\"datePublished\":\"2024-12-11T14:48:03+00:00\",\"dateModified\":\"2024-12-11T14:48:03+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/express24.ir\/d\/product\/%d8%aa%d8%b1%d8%ac%d9%85%d9%87-%d9%81%d8%a7%d8%b1%d8%b3%db%8c-%d9%85%d9%82%d8%a7%d9%84%d9%87-50965\/#breadcrumb\"},\"inLanguage\":\"fa-IR\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/express24.ir\/d\/product\/%d8%aa%d8%b1%d8%ac%d9%85%d9%87-%d9%81%d8%a7%d8%b1%d8%b3%db%8c-%d9%85%d9%82%d8%a7%d9%84%d9%87-50965\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/express24.ir\/d\/product\/%d8%aa%d8%b1%d8%ac%d9%85%d9%87-%d9%81%d8%a7%d8%b1%d8%b3%db%8c-%d9%85%d9%82%d8%a7%d9%84%d9%87-50965\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u062e\u0627\u0646\u0647\",\"item\":\"https:\/\/express24.ir\/d\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"\u0641\u0631\u0648\u0634\u06af\u0627\u0647\",\"item\":\"https:\/\/express24.ir\/d\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"\u062a\u0631\u062c\u0645\u0647 \u0641\u0627\u0631\u0633\u06cc \u0645\u0642\u0627\u0644\u0647 \u0627\u0632 \u062f\u0633\u062a \u062f\u0627\u062f\u0646 \u0639\u0645\u0644\u06a9\u0631\u062f \u067e\u0631\u0648\u062a\u0626\u06cc\u0646 \u0645\u062a\u0635\u0644 \u0634\u0648\u0646\u062f\u0647 \u0628\u0647 RNA PRRC2B \u0628\u0627\u0639\u062b \u0646\u0642\u0635 \u062a\u0631\u062c\u0645\u0647 \u0648 \u0646\u0627\u0647\u0646\u062c\u0627\u0631\u06cc \u0645\u0627\u062f\u0631\u0632\u0627\u062f\u06cc \u0642\u0644\u0628\u06cc \u0639\u0631\u0648\u0642\u06cc \u0645\u06cc \u0634\u0648\u062f.\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/express24.ir\/d\/#website\",\"url\":\"https:\/\/express24.ir\/d\/\",\"name\":\"\u0641\u0631\u0648\u0634\u06af\u0627\u0647 \u0627\u06a9\u0633\u067e\u0631\u0633\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/express24.ir\/d\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"fa-IR\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"\u062a\u0631\u062c\u0645\u0647 \u0641\u0627\u0631\u0633\u06cc \u0645\u0642\u0627\u0644\u0647 \u0627\u0632 \u062f\u0633\u062a \u062f\u0627\u062f\u0646 \u0639\u0645\u0644\u06a9\u0631\u062f \u067e\u0631\u0648\u062a\u0626\u06cc\u0646 \u0645\u062a\u0635\u0644 \u0634\u0648\u0646\u062f\u0647 \u0628\u0647 RNA PRRC2B \u0628\u0627\u0639\u062b \u0646\u0642\u0635 \u062a\u0631\u062c\u0645\u0647 \u0648 \u0646\u0627\u0647\u0646\u062c\u0627\u0631\u06cc \u0645\u0627\u062f\u0631\u0632\u0627\u062f\u06cc \u0642\u0644\u0628\u06cc \u0639\u0631\u0648\u0642\u06cc \u0645\u06cc \u0634\u0648\u062f. - \u0641\u0631\u0648\u0634\u06af\u0627\u0647 \u0627\u06a9\u0633\u067e\u0631\u0633","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/express24.ir\/d\/product\/\u062a\u0631\u062c\u0645\u0647-\u0641\u0627\u0631\u0633\u06cc-\u0645\u0642\u0627\u0644\u0647-50965\/","og_locale":"fa_IR","og_type":"article","og_title":"\u062a\u0631\u062c\u0645\u0647 \u0641\u0627\u0631\u0633\u06cc \u0645\u0642\u0627\u0644\u0647 \u0627\u0632 \u062f\u0633\u062a \u062f\u0627\u062f\u0646 \u0639\u0645\u0644\u06a9\u0631\u062f \u067e\u0631\u0648\u062a\u0626\u06cc\u0646 \u0645\u062a\u0635\u0644 \u0634\u0648\u0646\u062f\u0647 \u0628\u0647 RNA PRRC2B \u0628\u0627\u0639\u062b \u0646\u0642\u0635 \u062a\u0631\u062c\u0645\u0647 \u0648 \u0646\u0627\u0647\u0646\u062c\u0627\u0631\u06cc \u0645\u0627\u062f\u0631\u0632\u0627\u062f\u06cc \u0642\u0644\u0628\u06cc \u0639\u0631\u0648\u0642\u06cc \u0645\u06cc \u0634\u0648\u062f. - \u0641\u0631\u0648\u0634\u06af\u0627\u0647 \u0627\u06a9\u0633\u067e\u0631\u0633","og_description":"\u0639\u0646\u0648\u0627\u0646 \u0645\u0642\u0627\u0644\u0647 \u0628\u0647 \u0627\u0646\u06af\u0644\u06cc\u0633\u06cc Loss-of-function of RNA-binding protein PRRC2B causes translational defects and congenital cardiovascular malformation \u0639\u0646\u0648\u0627\u0646 \u0645\u0642\u0627\u0644\u0647 \u0628\u0647 \u0641\u0627\u0631\u0633\u06cc […]","og_url":"https:\/\/express24.ir\/d\/product\/\u062a\u0631\u062c\u0645\u0647-\u0641\u0627\u0631\u0633\u06cc-\u0645\u0642\u0627\u0644\u0647-50965\/","og_site_name":"\u0641\u0631\u0648\u0634\u06af\u0627\u0647 \u0627\u06a9\u0633\u067e\u0631\u0633","og_image":[{"width":440,"height":486,"url":"https:\/\/express24.ir\/d\/wp-content\/uploads\/2024\/02\/Elsevier_logo_2019.svg_.png","type":"image\/png"}],"twitter_card":"summary_large_image","twitter_misc":{"\u0632\u0645\u0627\u0646 \u062a\u0642\u0631\u06cc\u0628\u06cc \u0628\u0631\u0627\u06cc \u062e\u0648\u0627\u0646\u062f\u0646":"2 \u062f\u0642\u06cc\u0642\u0647"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/express24.ir\/d\/product\/%d8%aa%d8%b1%d8%ac%d9%85%d9%87-%d9%81%d8%a7%d8%b1%d8%b3%db%8c-%d9%85%d9%82%d8%a7%d9%84%d9%87-50965\/","url":"https:\/\/express24.ir\/d\/product\/%d8%aa%d8%b1%d8%ac%d9%85%d9%87-%d9%81%d8%a7%d8%b1%d8%b3%db%8c-%d9%85%d9%82%d8%a7%d9%84%d9%87-50965\/","name":"\u062a\u0631\u062c\u0645\u0647 \u0641\u0627\u0631\u0633\u06cc \u0645\u0642\u0627\u0644\u0647 \u0627\u0632 \u062f\u0633\u062a \u062f\u0627\u062f\u0646 \u0639\u0645\u0644\u06a9\u0631\u062f \u067e\u0631\u0648\u062a\u0626\u06cc\u0646 \u0645\u062a\u0635\u0644 \u0634\u0648\u0646\u062f\u0647 \u0628\u0647 RNA PRRC2B \u0628\u0627\u0639\u062b \u0646\u0642\u0635 \u062a\u0631\u062c\u0645\u0647 \u0648 \u0646\u0627\u0647\u0646\u062c\u0627\u0631\u06cc \u0645\u0627\u062f\u0631\u0632\u0627\u062f\u06cc \u0642\u0644\u0628\u06cc \u0639\u0631\u0648\u0642\u06cc \u0645\u06cc \u0634\u0648\u062f. - \u0641\u0631\u0648\u0634\u06af\u0627\u0647 \u0627\u06a9\u0633\u067e\u0631\u0633","isPartOf":{"@id":"https:\/\/express24.ir\/d\/#website"},"datePublished":"2024-12-11T14:48:03+00:00","dateModified":"2024-12-11T14:48:03+00:00","breadcrumb":{"@id":"https:\/\/express24.ir\/d\/product\/%d8%aa%d8%b1%d8%ac%d9%85%d9%87-%d9%81%d8%a7%d8%b1%d8%b3%db%8c-%d9%85%d9%82%d8%a7%d9%84%d9%87-50965\/#breadcrumb"},"inLanguage":"fa-IR","potentialAction":[{"@type":"ReadAction","target":["https:\/\/express24.ir\/d\/product\/%d8%aa%d8%b1%d8%ac%d9%85%d9%87-%d9%81%d8%a7%d8%b1%d8%b3%db%8c-%d9%85%d9%82%d8%a7%d9%84%d9%87-50965\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/express24.ir\/d\/product\/%d8%aa%d8%b1%d8%ac%d9%85%d9%87-%d9%81%d8%a7%d8%b1%d8%b3%db%8c-%d9%85%d9%82%d8%a7%d9%84%d9%87-50965\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"\u062e\u0627\u0646\u0647","item":"https:\/\/express24.ir\/d\/"},{"@type":"ListItem","position":2,"name":"\u0641\u0631\u0648\u0634\u06af\u0627\u0647","item":"https:\/\/express24.ir\/d\/"},{"@type":"ListItem","position":3,"name":"\u062a\u0631\u062c\u0645\u0647 \u0641\u0627\u0631\u0633\u06cc \u0645\u0642\u0627\u0644\u0647 \u0627\u0632 \u062f\u0633\u062a \u062f\u0627\u062f\u0646 \u0639\u0645\u0644\u06a9\u0631\u062f \u067e\u0631\u0648\u062a\u0626\u06cc\u0646 \u0645\u062a\u0635\u0644 \u0634\u0648\u0646\u062f\u0647 \u0628\u0647 RNA PRRC2B \u0628\u0627\u0639\u062b \u0646\u0642\u0635 \u062a\u0631\u062c\u0645\u0647 \u0648 \u0646\u0627\u0647\u0646\u062c\u0627\u0631\u06cc \u0645\u0627\u062f\u0631\u0632\u0627\u062f\u06cc \u0642\u0644\u0628\u06cc \u0639\u0631\u0648\u0642\u06cc \u0645\u06cc \u0634\u0648\u062f."}]},{"@type":"WebSite","@id":"https:\/\/express24.ir\/d\/#website","url":"https:\/\/express24.ir\/d\/","name":"\u0641\u0631\u0648\u0634\u06af\u0627\u0647 \u0627\u06a9\u0633\u067e\u0631\u0633","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/express24.ir\/d\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"fa-IR"}]}},"_links":{"self":[{"href":"https:\/\/express24.ir\/d\/wp-json\/wp\/v2\/product\/50965","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/express24.ir\/d\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/express24.ir\/d\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/express24.ir\/d\/wp-json\/wp\/v2\/comments?post=50965"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/express24.ir\/d\/wp-json\/wp\/v2\/media\/27"}],"wp:attachment":[{"href":"https:\/\/express24.ir\/d\/wp-json\/wp\/v2\/media?parent=50965"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/express24.ir\/d\/wp-json\/wp\/v2\/product_cat?post=50965"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/express24.ir\/d\/wp-json\/wp\/v2\/product_tag?post=50965"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}