{"id":50929,"date":"2024-12-11T14:24:09","date_gmt":"2024-12-11T14:24:09","guid":{"rendered":""},"modified":"2024-12-11T14:24:09","modified_gmt":"2024-12-11T14:24:09","slug":"%d8%aa%d8%b1%d8%ac%d9%85%d9%87-%d9%81%d8%a7%d8%b1%d8%b3%db%8c-%d9%85%d9%82%d8%a7%d9%84%d9%87-50929","status":"publish","type":"product","link":"https:\/\/express24.ir\/d\/product\/%d8%aa%d8%b1%d8%ac%d9%85%d9%87-%d9%81%d8%a7%d8%b1%d8%b3%db%8c-%d9%85%d9%82%d8%a7%d9%84%d9%87-50929\/","title":{"rendered":"\u062a\u0631\u062c\u0645\u0647 \u0641\u0627\u0631\u0633\u06cc \u0645\u0642\u0627\u0644\u0647 \u0645\u0633\u06cc\u0631\u0647\u0627\u06cc \u0644\u06cc\u067e\u06cc\u062f\u06cc \u0645\u062f\u0644 \u0647\u0627\u06cc \u062e\u0637\u0631 \u0627\u0628\u062a\u0644\u0627 \u0628\u0647 \u0628\u06cc\u0645\u0627\u0631\u06cc \u0622\u0644\u0632\u0627\u06cc\u0645\u0631 \u0648 \u0627\u062e\u062a\u0644\u0627\u0644\u0627\u062a \u0634\u0646\u0627\u062e\u062a\u06cc \u062e\u0641\u06cc\u0641 \u0631\u0627 \u0628\u0647\u0628\u0648\u062f \u0645\u06cc \u0628\u062e\u0634\u062f."},"content":{"rendered":"\n\n\n\n\n\n\n\n\n\n\n\n
\u0639\u0646\u0648\u0627\u0646 \u0645\u0642\u0627\u0644\u0647 \u0628\u0647 \u0627\u0646\u06af\u0644\u06cc\u0633\u06cc <\/td>\nLipid Trajectories Improve Risk Models for Alzheimer\u2019s Disease and Mild Cognitive Impairment<\/td>\n<\/tr>\n
\u0639\u0646\u0648\u0627\u0646 \u0645\u0642\u0627\u0644\u0647 \u0628\u0647 \u0641\u0627\u0631\u0633\u06cc <\/td>\n\u062a\u0631\u062c\u0645\u0647 \u0641\u0627\u0631\u0633\u06cc \u0645\u0642\u0627\u0644\u0647 \u0645\u0633\u06cc\u0631\u0647\u0627\u06cc \u0644\u06cc\u067e\u06cc\u062f\u06cc \u0645\u062f\u0644 \u0647\u0627\u06cc \u062e\u0637\u0631 \u0627\u0628\u062a\u0644\u0627 \u0628\u0647 \u0628\u06cc\u0645\u0627\u0631\u06cc \u0622\u0644\u0632\u0627\u06cc\u0645\u0631 \u0648 \u0627\u062e\u062a\u0644\u0627\u0644\u0627\u062a \u0634\u0646\u0627\u062e\u062a\u06cc \u062e\u0641\u06cc\u0641 \u0631\u0627 \u0628\u0647\u0628\u0648\u062f \u0645\u06cc \u0628\u062e\u0634\u062f.<\/td>\n<\/tr>\n
\u0646\u0648\u06cc\u0633\u0646\u062f\u06af\u0627\u0646 <\/td>\n ProfileBruce A. Chase, Roberta Frigerio, Chad J. Yucus, Smita Patel, Demetrius Maraganore, Alan R. Sanders, Jubao Duan, Katerina Markopoulou<\/td>\n<\/tr>\n
\u0641\u0631\u0645\u062a \u0645\u0642\u0627\u0644\u0647 \u0627\u0646\u06af\u0644\u06cc\u0633\u06cc <\/td>\nPDF<\/td>\n<\/tr>\n
\u0632\u0628\u0627\u0646 \u0645\u0642\u0627\u0644\u0647 \u062a\u062d\u0648\u06cc\u0644\u06cc <\/td>\n\u062a\u0631\u062c\u0645\u0647 \u0641\u0627\u0631\u0633\u06cc<\/td>\n<\/tr>\n
\u0641\u0631\u0645\u062a \u0645\u0642\u0627\u0644\u0647 \u062a\u0631\u062c\u0645\u0647 \u0634\u062f\u0647 <\/td>\n\u0628\u0647 \u0635\u0648\u0631\u062a \u0641\u0627\u06cc\u0644 \u0648\u0631\u062f<\/td>\n<\/tr>\n
\u0646\u062d\u0648\u0647 \u062a\u062d\u0648\u06cc\u0644 \u062a\u0631\u062c\u0645\u0647 <\/td>\n\u062f\u0648 \u062a\u0627 \u0633\u0647 \u0631\u0648\u0632 \u067e\u0633 \u0627\u0632 \u062b\u0628\u062a \u0633\u0641\u0627\u0631\u0634 (\u0628\u0647 \u0635\u0648\u0631\u062a \u0641\u0627\u06cc\u0644 \u062f\u0627\u0646\u0644\u0648\u062f\u06cc)<\/td>\n<\/tr>\n
\u062a\u0639\u062f\u0627\u062f \u0635\u0641\u062d\u0627\u062a<\/td>\n74<\/td>\n<\/tr>\n
\u0644\u06cc\u0646\u06a9 \u062f\u0627\u0646\u0644\u0648\u062f \u0631\u0627\u06cc\u06af\u0627\u0646 \u0645\u0642\u0627\u0644\u0647 \u0627\u0646\u06af\u0644\u06cc\u0633\u06cc<\/td>\n\u062f\u0627\u0646\u0644\u0648\u062f \u0645\u0642\u0627\u0644\u0647<\/a><\/td>\n<\/tr>\n
\u062f\u0633\u062a\u0647 \u0628\u0646\u062f\u06cc \u0645\u0648\u0636\u0648\u0639\u0627\u062a <\/td>\nNeurology
\n\u0639\u0635\u0628 \u0634\u0646\u0627\u0633\u06cc<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\r\n\r\n \r\n \r\n \r\n \r\n
\u0641\u0631\u0645\u062a \u0627\u0631\u0627\u0626\u0647 \u062a\u0631\u062c\u0645\u0647 \u0645\u0642\u0627\u0644\u0647 <\/td>\r\n \u062a\u062d\u0648\u06cc\u0644 \u0628\u0647 \u0635\u0648\u0631\u062a \u0641\u0627\u06cc\u0644 \u0648\u0631\u062f<\/td>\r\n <\/tr>\r\n
\u0632\u0645\u0627\u0646 \u062a\u062d\u0648\u06cc\u0644 \u062a\u0631\u062c\u0645\u0647 \u0645\u0642\u0627\u0644\u0647 <\/td>\r\n \u0628\u06cc\u0646 2 \u062a\u0627 3 \u0631\u0648\u0632 \u067e\u0633 \u0627\u0632 \u062b\u0628\u062a \u0633\u0641\u0627\u0631\u0634<\/td>\r\n <\/tr>\r\n\t
\u06a9\u06cc\u0641\u06cc\u062a \u062a\u0631\u062c\u0645\u0647 <\/td>\r\n \u0628\u0633\u06cc\u0627\u0631 \u0628\u0627\u0644\u0627. \u0645\u0642\u0627\u0644\u0647 \u0641\u0642\u0637 \u062a\u0648\u0633\u0637 \u0645\u062a\u0631\u062c\u0645\u06cc\u0646 \u0628\u0627 \u0645\u062f\u0631\u06a9 \u062f\u0627\u0646\u0634\u06af\u0627\u0647\u06cc \u0645\u062a\u0631\u062c\u0645\u06cc \u062a\u0631\u062c\u0645\u0647 \u0645\u06cc\u200c\u0634\u0648\u062f.<\/td>\r\n <\/tr>\r\n\t\t
\u062c\u062f\u0627\u0648\u0644 \u0648 \u0641\u0631\u0645\u0648\u0644 \u0647\u0627 <\/td>\r\n \u06a9\u0644\u06cc\u0647 \u062c\u062f\u0627\u0648\u0644 \u0648 \u0641\u0631\u0645\u0648\u0644 \u0647\u0627 \u0646\u06cc\u0632 \u062f\u0631 \u0641\u0627\u06cc\u0644 \u062a\u062d\u0648\u06cc\u0644\u06cc \u0648\u0631\u062f \u062f\u0631\u062c \u0645\u06cc\u200c\u0634\u0648\u0646\u062f.<\/td>\r\n <\/tr>\r\n<\/table>\r\n\r\n\n

\u0686\u06a9\u06cc\u062f\u0647<\/h2>\n

To assess the relationship between lipids and cognitive dysfunction, we retrospectively analyzed blood-lipid levels in clinically well-characterized individuals with stable mild cognitive impairment (MCI) or Alzheimer\u2019s disease (AD) over the decade prior to first cognitive symptoms. In this case\/control cohort study, AD and MCI cases were diagnosed using DSM-IV criteria; MCI cases had not progressed to dementia for \u22655 years; and controls were propensity matched to cases at age of symptom onset (MCI: 116 cases, 435 controls; AD: 215 cases, 483 controls). Participants were grouped based on longitudinal trajectories and quintile of variability independent of the mean (VIM) for total cholesterol, HDL-C, LDL-C, non-HDL-C and ln(triglycerides). Models for the risk of cognitive dysfunction evaluated trajectory and VIM groups, APOE genotype, polygenic risk scores (PRS) for AD and lipid levels, age, comorbidities, and longitudinal correlates of blood-lipid concentrations. Lower HDL-C trajectories (OR = 3.8, 95% CI = 1.3\u201311.3) and the lowest VIM quintile of non-HDL-C (OR = 2.2, 95% CI = 1.3\u20133.0) were associated with higher MCI risk. Lower HDL-C trajectories (OR = 3.0, 95% CI = 1.6\u20135.7) and the lowest VIM quintile of total cholesterol (OR = 2.4, 95% CI = 1.5\u20133.9) were associated with higher AD risk. The inclusion of lipid-trajectory and VIM groups improved risk-model predictive performance independent of APOE genotype or PRS for AD and lipid levels. These results provide an important real-world perspective on the influence of lipid metabolism and blood-lipid levels on the development of stable MCI and AD.<\/p>\n

\u0686\u06a9\u06cc\u062f\u0647 \u0628\u0647 \u0641\u0627\u0631\u0633\u06cc (\u062a\u0631\u062c\u0645\u0647 \u0645\u0627\u0634\u06cc\u0646\u06cc)<\/h2>\n

\u0628\u0631\u0627\u06cc \u0627\u0631\u0632\u06cc\u0627\u0628\u06cc \u0631\u0627\u0628\u0637\u0647 \u0628\u06cc\u0646 \u0644\u06cc\u067e\u06cc\u062f\u0647\u0627 \u0648 \u0627\u062e\u062a\u0644\u0627\u0644 \u0639\u0645\u0644\u06a9\u0631\u062f \u0634\u0646\u0627\u062e\u062a\u06cc \u060c \u0645\u0627 \u0628\u0647 \u0635\u0648\u0631\u062a \u06af\u0630\u0634\u062a\u0647 \u0646\u06af\u0631 \u0633\u0637\u062d \u0644\u06cc\u067e\u06cc\u062f \u062e\u0648\u0646 \u062f\u0631 \u0627\u0641\u0631\u0627\u062f \u0628\u0627 \u0645\u0634\u062e\u0635\u0647 \u0628\u0627\u0644\u06cc\u0646\u06cc \u0628\u0627 \u0627\u062e\u062a\u0644\u0627\u0644 \u0634\u0646\u0627\u062e\u062a\u06cc \u062e\u0641\u06cc\u0641 \u067e\u0627\u06cc\u062f\u0627\u0631 (MCI) \u06cc\u0627 \u0628\u06cc\u0645\u0627\u0631\u06cc \u0622\u0644\u0632\u0627\u06cc\u0645\u0631 (AD) \u062f\u0631 \u0637\u06cc \u06cc\u06a9 \u062f\u0647\u0647 \u0642\u0628\u0644 \u0627\u0632 \u0627\u0648\u0644\u06cc\u0646 \u0639\u0644\u0627\u0626\u0645 \u0634\u0646\u0627\u062e\u062a\u06cc \u0645\u0648\u0631\u062f \u062a\u062c\u0632\u06cc\u0647 \u0648 \u062a\u062d\u0644\u06cc\u0644 \u0642\u0631\u0627\u0631 \u06af\u0631\u0641\u062a\u06cc\u0645.\u062f\u0631 \u0627\u06cc\u0646 \u0645\u0637\u0627\u0644\u0639\u0647 \u06a9\u0648\u0647\u0648\u0631\u062a \u06a9\u0646\u062a\u0631\u0644 \u060c \u0645\u0648\u0627\u0631\u062f AD \u0648 MCI \u0628\u0627 \u0627\u0633\u062a\u0641\u0627\u062f\u0647 \u0627\u0632 \u0645\u0639\u06cc\u0627\u0631\u0647\u0627\u06cc DSM-IV \u062a\u0634\u062e\u06cc\u0635 \u062f\u0627\u062f\u0647 \u0634\u062f.\u0645\u0648\u0627\u0631\u062f MCI \u0628\u0647 \u0645\u062f\u062a 5 \u0633\u0627\u0644 \u0628\u0647 \u0632\u0648\u0627\u0644 \u0639\u0642\u0644 \u067e\u06cc\u0634\u0631\u0641\u062a \u0646\u06a9\u0631\u062f\u0647 \u0628\u0648\u062f.\u0648 \u06a9\u0646\u062a\u0631\u0644 \u0647\u0627 \u0645\u0637\u0627\u0628\u0642 \u0628\u0627 \u0645\u0648\u0627\u0631\u062f \u062f\u0631 \u0633\u0646 \u0634\u0631\u0648\u0639 \u0639\u0644\u0627\u0626\u0645 \u0628\u0648\u062f (MCI: 116 \u0645\u0648\u0631\u062f \u060c 435 \u06a9\u0646\u062a\u0631\u0644 \u061b AD: 215 \u0645\u0648\u0631\u062f \u060c 483 \u06a9\u0646\u062a\u0631\u0644).\u0634\u0631\u06a9\u062a \u06a9\u0646\u0646\u062f\u06af\u0627\u0646 \u0628\u0631 \u0627\u0633\u0627\u0633 \u0645\u0633\u06cc\u0631\u0647\u0627\u06cc \u0637\u0648\u0644\u06cc \u0648 \u067e\u0646\u062c\u0645 \u062a\u0646\u0648\u0639 \u0645\u0633\u062a\u0642\u0644 \u0627\u0632 \u0645\u06cc\u0627\u0646\u06af\u06cc\u0646 (VIM) \u0628\u0631\u0627\u06cc \u06a9\u0644\u0633\u062a\u0631\u0648\u0644 \u06a9\u0644 \u060c HDL-C \u060c LDL-C \u060c \u063a\u06cc\u0631 HDL-C \u0648 LN (\u062a\u0631\u06cc \u06af\u0644\u06cc\u0633\u06cc\u0631\u06cc\u062f\u0647\u0627) \u06af\u0631\u0648\u0647 \u0628\u0646\u062f\u06cc \u0634\u062f\u0646\u062f.\u0645\u062f\u0644 \u0647\u0627\u06cc\u06cc \u0628\u0631\u0627\u06cc \u062e\u0637\u0631 \u0627\u062e\u062a\u0644\u0627\u0644 \u0639\u0645\u0644\u06a9\u0631\u062f \u0634\u0646\u0627\u062e\u062a\u06cc \u060c \u06af\u0631\u0648\u0647 \u0647\u0627\u06cc \u0645\u0633\u06cc\u0631 \u0648 VIM \u060c \u0698\u0646\u0648\u062a\u06cc\u067e APOE \u060c \u0646\u0645\u0631\u0627\u062a \u062e\u0637\u0631 \u067e\u0644\u06cc \u0698\u0646\u06cc\u06a9 (PRS) \u0631\u0627 \u0628\u0631\u0627\u06cc \u0633\u0637\u062d AD \u0648 \u0644\u06cc\u067e\u06cc\u062f\u0647\u0627 \u060c \u0633\u0646 \u060c \u0639\u0648\u0627\u0631\u0636 \u0648 \u0647\u0645\u0628\u0633\u062a\u06af\u06cc \u0637\u0648\u0644\u06cc \u063a\u0644\u0638\u062a \u0644\u06cc\u067e\u06cc\u062f \u062e\u0648\u0646 \u0627\u0631\u0632\u06cc\u0627\u0628\u06cc \u0645\u06cc \u06a9\u0646\u062f.\u0645\u0633\u06cc\u0631\u0647\u0627\u06cc HDL-C \u067e\u0627\u06cc\u06cc\u0646 \u062a\u0631 (OR = 3.8 \u060c 95 \u066a CI = 1.3-11.3) \u0648 \u06a9\u0645\u062a\u0631\u06cc\u0646 Quintile VIM \u063a\u06cc\u0631 HDL-C (OR = 2.2 \u060c 95 \u066a CI = 1.3-3.0) \u0628\u0627 \u062e\u0637\u0631 MCI \u0628\u0627\u0644\u0627\u062a\u0631 \u0647\u0645\u0631\u0627\u0647 \u0628\u0648\u062f\u0646\u062f.\u0645\u0633\u06cc\u0631\u0647\u0627\u06cc \u067e\u0627\u06cc\u06cc\u0646 HDL-C (OR = 3.0 \u060c 95 \u066a CI = 1.6-5.7) \u0648 \u06a9\u0645\u062a\u0631\u06cc\u0646 \u06a9\u0648\u0626\u06cc\u0646\u062a\u06cc\u0644 VIM \u06a9\u0644\u0633\u062a\u0631\u0648\u0644 \u06a9\u0644 (OR = 2.4 \u060c 95 \u066a CI = 1.5-3.9) \u0628\u0627 \u062e\u0637\u0631 AD \u0628\u0627\u0644\u0627\u062a\u0631 \u0647\u0645\u0631\u0627\u0647 \u0628\u0648\u062f\u0646\u062f.\u06af\u0646\u062c\u0627\u0646\u062f\u0646 \u06af\u0631\u0648\u0647\u0647\u0627\u06cc \u0644\u06cc\u067e\u06cc\u062f\u06cc \u0648 \u0633\u06cc\u067e\u0644\u067e\u062a\u0648\u0631\u06cc \u0648 VIM \u0639\u0645\u0644\u06a9\u0631\u062f \u067e\u06cc\u0634 \u0628\u06cc\u0646\u06cc \u0645\u062f\u0644 \u0631\u06cc\u0633\u06a9 \u0631\u0627 \u0645\u0633\u062a\u0642\u0644 \u0627\u0632 \u0698\u0646\u0648\u062a\u06cc\u067e APOE \u06cc\u0627 PRS \u0628\u0631\u0627\u06cc \u0633\u0637\u062d AD \u0648 \u0644\u06cc\u067e\u06cc\u062f\u0647\u0627 \u0628\u0647\u0628\u0648\u062f \u0628\u062e\u0634\u06cc\u062f.\u0627\u06cc\u0646 \u0646\u062a\u0627\u06cc\u062c \u0686\u0634\u0645 \u0627\u0646\u062f\u0627\u0632 \u0645\u0647\u0645\u06cc \u062f\u0631 \u062f\u0646\u06cc\u0627\u06cc \u0648\u0627\u0642\u0639\u06cc \u062f\u0631 \u0645\u0648\u0631\u062f \u062a\u0623\u062b\u06cc\u0631 \u0645\u062a\u0627\u0628\u0648\u0644\u06cc\u0633\u0645 \u0644\u06cc\u067e\u06cc\u062f\u0647\u0627 \u0648 \u0633\u0637\u062d \u0644\u06cc\u067e\u06cc\u062f \u062e\u0648\u0646 \u062f\u0631 \u062a\u0648\u0633\u0639\u0647 MCI \u067e\u0627\u06cc\u062f\u0627\u0631 \u0648 AD \u0627\u0631\u0627\u0626\u0647 \u0645\u06cc \u062f\u0647\u062f.<\/p>\n\r\n\r\n \r\n \r\n \r\n \r\n
\u0641\u0631\u0645\u062a \u0627\u0631\u0627\u0626\u0647 \u062a\u0631\u062c\u0645\u0647 \u0645\u0642\u0627\u0644\u0647 <\/td>\r\n \u062a\u062d\u0648\u06cc\u0644 \u0628\u0647 \u0635\u0648\u0631\u062a \u0641\u0627\u06cc\u0644 \u0648\u0631\u062f<\/td>\r\n <\/tr>\r\n
\u0632\u0645\u0627\u0646 \u062a\u062d\u0648\u06cc\u0644 \u062a\u0631\u062c\u0645\u0647 \u0645\u0642\u0627\u0644\u0647 <\/td>\r\n \u0628\u06cc\u0646 2 \u062a\u0627 3 \u0631\u0648\u0632 \u067e\u0633 \u0627\u0632 \u062b\u0628\u062a \u0633\u0641\u0627\u0631\u0634<\/td>\r\n <\/tr>\r\n\t
\u06a9\u06cc\u0641\u06cc\u062a \u062a\u0631\u062c\u0645\u0647 <\/td>\r\n \u0628\u0633\u06cc\u0627\u0631 \u0628\u0627\u0644\u0627. \u0645\u0642\u0627\u0644\u0647 \u0641\u0642\u0637 \u062a\u0648\u0633\u0637 \u0645\u062a\u0631\u062c\u0645\u06cc\u0646 \u0628\u0627 \u0645\u062f\u0631\u06a9 \u062f\u0627\u0646\u0634\u06af\u0627\u0647\u06cc \u0645\u062a\u0631\u062c\u0645\u06cc \u062a\u0631\u062c\u0645\u0647 \u0645\u06cc\u200c\u0634\u0648\u062f.<\/td>\r\n <\/tr>\r\n\t\t
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