{"id":50762,"date":"2024-12-09T14:05:18","date_gmt":"2024-12-09T14:05:18","guid":{"rendered":""},"modified":"2024-12-09T14:05:18","modified_gmt":"2024-12-09T14:05:18","slug":"%d8%aa%d8%b1%d8%ac%d9%85%d9%87-%d9%81%d8%a7%d8%b1%d8%b3%db%8c-%d9%85%d9%82%d8%a7%d9%84%d9%87-50762","status":"publish","type":"product","link":"https:\/\/express24.ir\/d\/product\/%d8%aa%d8%b1%d8%ac%d9%85%d9%87-%d9%81%d8%a7%d8%b1%d8%b3%db%8c-%d9%85%d9%82%d8%a7%d9%84%d9%87-50762\/","title":{"rendered":"\u062a\u0631\u062c\u0645\u0647 \u0641\u0627\u0631\u0633\u06cc \u0645\u0642\u0627\u0644\u0647 \u0646\u0642\u0634 MicroRNA \u0647\u0627 \u062f\u0631 \u0628\u06cc\u0645\u0627\u0631\u06cc \u06a9\u0644\u06cc\u0647 \u067e\u0644\u06cc \u06a9\u06cc\u0633\u062a\u06cc\u06a9 \u0627\u062a\u0648\u0632\u0648\u0645\u0627\u0644 \u063a\u0627\u0644\u0628: \u0646\u0645\u0627\u06cc\u0647 \u0647\u0627\u06cc \u0628\u06cc\u0627\u0646 \u0648 \u0622\u0646\u0627\u0644\u06cc\u0632 \u0645\u0633\u06cc\u0631"},"content":{"rendered":"\n\n\n\n\n\n\n\n\n\n\n\n
\u0639\u0646\u0648\u0627\u0646 \u0645\u0642\u0627\u0644\u0647 \u0628\u0647 \u0627\u0646\u06af\u0644\u06cc\u0633\u06cc <\/td>\nRole of MicroRNAs in Autosomal Dominant Polycystic Kidney Disease: Expression Profiles and Pathway Analysis<\/td>\n<\/tr>\n
\u0639\u0646\u0648\u0627\u0646 \u0645\u0642\u0627\u0644\u0647 \u0628\u0647 \u0641\u0627\u0631\u0633\u06cc <\/td>\n\u062a\u0631\u062c\u0645\u0647 \u0641\u0627\u0631\u0633\u06cc \u0645\u0642\u0627\u0644\u0647 \u0646\u0642\u0634 MicroRNA \u0647\u0627 \u062f\u0631 \u0628\u06cc\u0645\u0627\u0631\u06cc \u06a9\u0644\u06cc\u0647 \u067e\u0644\u06cc \u06a9\u06cc\u0633\u062a\u06cc\u06a9 \u0627\u062a\u0648\u0632\u0648\u0645\u0627\u0644 \u063a\u0627\u0644\u0628: \u0646\u0645\u0627\u06cc\u0647 \u0647\u0627\u06cc \u0628\u06cc\u0627\u0646 \u0648 \u0622\u0646\u0627\u0644\u06cc\u0632 \u0645\u0633\u06cc\u0631<\/td>\n<\/tr>\n
\u0646\u0648\u06cc\u0633\u0646\u062f\u06af\u0627\u0646 <\/td>\n ProfileChandra Devi, ProfilePrashant Ranjan, Jitendra Kumar Mishra, Shivendra Singh, ProfileParimal Das<\/td>\n<\/tr>\n
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\n\u0646\u0641\u0631\u0648\u0644\u0648\u0698\u06cc<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\r\n\r\n \r\n \r\n \r\n \r\n
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\u062c\u062f\u0627\u0648\u0644 \u0648 \u0641\u0631\u0645\u0648\u0644 \u0647\u0627 <\/td>\r\n \u06a9\u0644\u06cc\u0647 \u062c\u062f\u0627\u0648\u0644 \u0648 \u0641\u0631\u0645\u0648\u0644 \u0647\u0627 \u0646\u06cc\u0632 \u062f\u0631 \u0641\u0627\u06cc\u0644 \u062a\u062d\u0648\u06cc\u0644\u06cc \u0648\u0631\u062f \u062f\u0631\u062c \u0645\u06cc\u200c\u0634\u0648\u0646\u062f.<\/td>\r\n <\/tr>\r\n<\/table>\r\n\r\n\n

\u0686\u06a9\u06cc\u062f\u0647<\/h2>\n

This study investigates the role of specific microRNAs (miRNAs) in autosomal dominant polycystic kidney disease (ADPKD). Network analysis using Cytoscape 3.10.1 revealed 28 miRNAs that target two or more PKD related genes, while 14 miRNAs interacted with three or more genes. Pathway analysis of these 14 miRNAs, conducted via the miRPath V4.0 tool, utilized various resources such as KEGG, GO terms, Pfam, and MSigDB, highlighting their functional roles in ADPKD. Among these 14 miRNAs, four were prioritized for further analysis based on the higher number of target genes and existing evidence of their expression in blood. These miRNAs were analyzed for fold change expression levels using qRT-PCR on blood-derived RNA samples from ADPKD patients (n=19) and healthy controls (n=5). These four miRNAs\u2014hsa-miR20a-5p, hsa-miR27b-3p, hsa-miR3613-3p, and hsa-miR181a-5p\u2014 showed significant upregulation with p-values of 0.0179, 0.0002, 0.0166, and 0.0402 respectively. The functional enrichment of miRNAs involved in PKD evidently suggests that these play diverse roles in regulating key processes such as cell cycle progression, mTOR signaling, autophagy, EMT, and cellular responses to hypoxia thus playing crucial role in the pathogenesis of ADPKD and could serve as potential biomarkers or therapeutic targets.<\/p>\n

\u0686\u06a9\u06cc\u062f\u0647 \u0628\u0647 \u0641\u0627\u0631\u0633\u06cc (\u062a\u0631\u062c\u0645\u0647 \u0645\u0627\u0634\u06cc\u0646\u06cc)<\/h2>\n

\u0627\u06cc\u0646 \u0645\u0637\u0627\u0644\u0639\u0647 \u0628\u0647 \u0628\u0631\u0631\u0633\u06cc \u0646\u0642\u0634 \u0645\u06cc\u06a9\u0631\u0648 RNA \u0647\u0627\u06cc \u062e\u0627\u0635 (miRNA) \u062f\u0631 \u0628\u06cc\u0645\u0627\u0631\u06cc \u06a9\u0644\u06cc\u0648\u06cc \u067e\u0644\u06cc \u06a9\u06cc\u0633\u062a\u06cc\u06a9 \u063a\u0627\u0644\u0628 \u0627\u062a\u0648\u0632\u0648\u0645\u0627\u0644 (ADPKD) \u0645\u06cc \u067e\u0631\u062f\u0627\u0632\u062f.\u062a\u062c\u0632\u06cc\u0647 \u0648 \u062a\u062d\u0644\u06cc\u0644 \u0634\u0628\u06a9\u0647 \u0628\u0627 \u0627\u0633\u062a\u0641\u0627\u062f\u0647 \u0627\u0632 Cytoscape 3.10.1 28 miRNA \u0631\u0627 \u0646\u0634\u0627\u0646 \u062f\u0627\u062f \u06a9\u0647 \u062f\u0648 \u06cc\u0627 \u0686\u0646\u062f \u0698\u0646 \u0645\u0631\u062a\u0628\u0637 \u0628\u0627 PKD \u0631\u0627 \u0647\u062f\u0641 \u0642\u0631\u0627\u0631 \u0645\u06cc \u062f\u0647\u0646\u062f \u060c \u062f\u0631 \u062d\u0627\u0644\u06cc \u06a9\u0647 14 miRNA 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\u0628\u06cc\u0645\u0627\u0631\u0627\u0646 ADPKD (19 \u0646\u0641\u0631) \u0648 \u06af\u0631\u0648\u0647 \u06a9\u0646\u062a\u0631\u0644 \u0633\u0627\u0644\u0645 (5 \u0646\u0641\u0631) \u0645\u0648\u0631\u062f \u0628\u0631\u0631\u0633\u06cc \u0642\u0631\u0627\u0631 \u06af\u0631\u0641\u062a.\u0627\u06cc\u0646 \u0686\u0647\u0627\u0631 miRNA-HSA-MIR20A-5P \u060c HSA-MIR27B-3P \u060c HSA-MIR3613-3P \u0648 HSA-MIR181A-5P\u2014 \u0628\u0647 \u062a\u0631\u062a\u06cc\u0628 \u062a\u0646\u0638\u06cc\u0645 \u0645\u0639\u0646\u06cc \u062f\u0627\u0631\u06cc \u0628\u0627 \u0645\u0642\u0627\u062f\u06cc\u0631 P 0.0179 \u060c 0.0002 \u060c 0.0166 \u0648 0.0402 \u0646\u0634\u0627\u0646 \u062f\u0627\u062f\u0646\u062f.\u063a\u0646\u06cc \u0633\u0627\u0632\u06cc \u0639\u0645\u0644\u06a9\u0631\u062f\u06cc miRNA \u0647\u0627\u06cc \u062f\u0631\u06af\u06cc\u0631 \u062f\u0631 PKD \u0628\u062f\u06cc\u0647\u06cc \u0627\u0633\u062a \u06a9\u0647 \u0627\u06cc\u0646\u0647\u0627 \u0646\u0642\u0634 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\u0641\u0631\u0645\u062a \u0627\u0631\u0627\u0626\u0647 \u062a\u0631\u062c\u0645\u0647 \u0645\u0642\u0627\u0644\u0647 <\/td>\r\n \u062a\u062d\u0648\u06cc\u0644 \u0628\u0647 \u0635\u0648\u0631\u062a \u0641\u0627\u06cc\u0644 \u0648\u0631\u062f<\/td>\r\n <\/tr>\r\n
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\u06a9\u06cc\u0641\u06cc\u062a \u062a\u0631\u062c\u0645\u0647 <\/td>\r\n \u0628\u0633\u06cc\u0627\u0631 \u0628\u0627\u0644\u0627. \u0645\u0642\u0627\u0644\u0647 \u0641\u0642\u0637 \u062a\u0648\u0633\u0637 \u0645\u062a\u0631\u062c\u0645\u06cc\u0646 \u0628\u0627 \u0645\u062f\u0631\u06a9 \u062f\u0627\u0646\u0634\u06af\u0627\u0647\u06cc \u0645\u062a\u0631\u062c\u0645\u06cc \u062a\u0631\u062c\u0645\u0647 \u0645\u06cc\u200c\u0634\u0648\u062f.<\/td>\r\n <\/tr>\r\n\t\t
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