{"id":228457,"date":"2025-11-10T06:46:57","date_gmt":"2025-11-10T07:46:57","guid":{"rendered":"https:\/\/express24.ir\/d\/product\/2301-04815\/"},"modified":"2025-11-10T06:46:57","modified_gmt":"2025-11-10T07:46:57","slug":"2301-04815","status":"publish","type":"product","link":"https:\/\/express24.ir\/d\/product\/2301-04815\/","title":{"rendered":"\u0645\u0642\u0627\u0644\u0647 \u062a\u062d\u0644\u06cc\u0644 \u06cc\u0627\u062f\u06af\u06cc\u0631\u06cc \u0645\u0627\u0634\u06cc\u0646 \u0627\u062e\u062a\u0644\u0627\u0644 \u0645\u0635\u0631\u0641 \u0645\u0648\u0627\u062f \u0627\u0641\u06cc\u0648\u0646\u06cc \u0628\u0631 \u067e\u0627\u06cc\u0647\u200c\u06cc \u0634\u0628\u06a9\u0647\u200c\u0647\u0627\u06cc \u0627\u06cc\u0646\u062a\u0631\u0627\u06a9\u062a\u0648\u0645\u0650 MOR, DOR, KOR, NOR \u0648 ZOR \u0628\u0647 \u0647\u0645\u0631\u0627\u0647 PDF \u0641\u0627\u0631\u0633\u06cc + \u067e\u0627\u062f\u06a9\u0633\u062a \u0635\u0648\u062a\u06cc \u0641\u0627\u0631\u0633\u06cc + \u0648\u06cc\u062f\u06cc\u0648 \u0622\u0645\u0648\u0632\u0634\u06cc \u0641\u0627\u0631\u0633\u06cc"},"content":{"rendered":"<div style=\"background: linear-gradient(135deg, #667eea 0%, #764ba2 100%); padding: 30px; border-radius: 15px; color: white; margin-bottom: 30px;\">\n<h2 style=\"color: white; text-align: center; margin-bottom: 20px;\">\ud83d\udcda \u0645\u0642\u0627\u0644\u0647 \u0639\u0644\u0645\u06cc<\/h2>\n<\/p><\/div>\n<table class=\"paper-info-table\" border=\"1\" cellpadding=\"10\" cellspacing=\"0\" style=\"width: 100%; margin-bottom: 20px; border-collapse: collapse; direction: rtl;\">\n<tr>\n<th style=\"background-color: #1F3A5E; color: white; text-align: right; width: 35%;\">\u0639\u0646\u0648\u0627\u0646 \u0641\u0627\u0631\u0633\u06cc \u0645\u0642\u0627\u0644\u0647<\/th>\n<td style=\"text-align: right; background-color: #f8f9fa; font-weight: bold;\">\u062a\u062d\u0644\u06cc\u0644 \u06cc\u0627\u062f\u06af\u06cc\u0631\u06cc \u0645\u0627\u0634\u06cc\u0646 \u0627\u062e\u062a\u0644\u0627\u0644 \u0645\u0635\u0631\u0641 \u0645\u0648\u0627\u062f \u0627\u0641\u06cc\u0648\u0646\u06cc \u0628\u0631 \u067e\u0627\u06cc\u0647\u200c\u06cc \u0634\u0628\u06a9\u0647\u200c\u0647\u0627\u06cc \u0627\u06cc\u0646\u062a\u0631\u0627\u06a9\u062a\u0648\u0645\u0650 MOR, DOR, KOR, NOR \u0648 ZOR<\/td>\n<\/tr>\n<tr>\n<th style=\"background-color: #1F3A5E; color: white; text-align: right;\">\u0646\u0648\u06cc\u0633\u0646\u062f\u06af\u0627\u0646<\/th>\n<td style=\"text-align: right; background-color: #ffffff;\">Hongsong Feng, Rana Elladki, Jian Jiang, Guo-Wei Wei<\/td>\n<\/tr>\n<tr>\n<th style=\"background-color: #1F3A5E; color: white; text-align: right;\">\u062f\u0633\u062a\u0647\u200c\u0628\u0646\u062f\u06cc \u0639\u0644\u0645\u06cc<\/th>\n<td style=\"text-align: right; background-color: #f8f9fa;\">Biomolecules<\/td>\n<\/tr>\n<\/table>\n<div style=\"border: 2px dashed #4CAF50; border-radius: 16px; padding: 20px; background: #f9fff9; font-family: 'IRANSans', sans-serif;\">\r\n  <h2 style=\"color: #2E7D32; margin-top: 0;\">\ud83d\udcd8 \u0645\u062d\u062a\u0648\u0627\u06cc \u0627\u06cc\u0646 \u0645\u0642\u0627\u0644\u0647 \u0622\u0645\u0648\u0632\u0634\u06cc<\/h2>\r\n  <ul style=\"list-style-type: \u2705; padding-left: 20px; font-size: 16px; line-height: 1.8;\">\r\n    <li>\u0634\u0627\u0645\u0644 <strong>\u0641\u0627\u06cc\u0644 \u0627\u0635\u0644\u06cc \u0645\u0642\u0627\u0644\u0647 (PDF \u0627\u0646\u06af\u0644\u06cc\u0633\u06cc)<\/strong><\/li>\r\n    <li>\u0628\u0647 \u0647\u0645\u0631\u0627\u0647 <strong>\u0641\u0627\u06cc\u0644 PDF \u062a\u0648\u0636\u06cc\u062d \u0641\u0627\u0631\u0633\u06cc<\/strong> \u0628\u0627 \u0628\u06cc\u0627\u0646 \u0633\u0627\u062f\u0647 \u0648 \u0631\u0648\u0627\u0646<\/li>\r\n    <li>\u062f\u0627\u0631\u0627\u06cc <strong>\u067e\u0627\u062f\u06a9\u0633\u062a \u0635\u0648\u062a\u06cc \u0641\u0627\u0631\u0633\u06cc<\/strong> \u062a\u0648\u0636\u06cc\u062d \u06a9\u0627\u0645\u0644 \u0645\u0642\u0627\u0644\u0647<\/li>\r\n    <li>\u0628\u0647 \u0647\u0645\u0631\u0627\u0647 <strong>\u0648\u06cc\u062f\u06cc\u0648 \u0622\u0645\u0648\u0632\u0634\u06cc \u0641\u0627\u0631\u0633\u06cc<\/strong> \u0628\u0631\u0627\u06cc \u062f\u0631\u06a9 \u0639\u0645\u06cc\u0642\u200c\u062a\u0631 \u0645\u0641\u0627\u0647\u06cc\u0645 \u0645\u0642\u0627\u0644\u0647<\/li>\r\n  <\/ul>\r\n  <p style=\"color: #388E3C; font-weight: bold; font-size: 18px; margin-top: 20px;\">\r\n    \ud83c\udfaf \u0647\u0645\u0647\u200c\u06cc \u0641\u0627\u06cc\u0644\u200c\u0647\u0627 \u0628\u0627 \u0647\u062f\u0641 \u062f\u0631\u06a9 \u0622\u0633\u0627\u0646 \u0648 \u0633\u0631\u06cc\u0639 \u0645\u0641\u0627\u0647\u06cc\u0645 \u0639\u0644\u0645\u06cc \u0627\u06cc\u0646 \u0645\u0642\u0627\u0644\u0647 \u062a\u0647\u06cc\u0647 \u0634\u062f\u0647\u200c\u0627\u0646\u062f.\r\n  <\/p>\r\n  <p style=\"font-size: 16px; line-height: 1.8;\">\r\n    \u0686\u0646\u0627\u0646\u0686\u0647 \u062f\u0631 <strong>\u062f\u0627\u0646\u0644\u0648\u062f \u0641\u0627\u06cc\u0644\u200c\u0647\u0627<\/strong> \u0628\u0627 \u0645\u0634\u06a9\u0644\u06cc \u0645\u0648\u0627\u062c\u0647 \u0634\u062f\u06cc\u062f\u060c \u0644\u0637\u0641\u0627\u064b \u0627\u0632 \u0637\u0631\u06cc\u0642 \u0648\u0627\u062a\u0633\u200c\u0627\u067e \u0628\u0627 \u0634\u0645\u0627\u0631\u0647 \r\n    <strong>09395106248<\/strong> \u06cc\u0627 \u0627\u0632 \u0637\u0631\u06cc\u0642 \u0622\u06cc\u062f\u06cc \u062a\u0644\u06af\u0631\u0627\u0645 \r\n    <strong>@ma_limbs<\/strong> \u067e\u06cc\u0627\u0645 \u062f\u0647\u06cc\u062f \u062a\u0627 \u0644\u06cc\u0646\u06a9\u200c\u0647\u0627 \u0641\u0648\u0631\u0627\u064b \u0628\u0631\u0627\u06cc\u062a\u0627\u0646 \u0645\u062c\u062f\u062f\u0627\u064b \u0627\u0631\u0633\u0627\u0644 \u0634\u0648\u0646\u062f.\r\n  <\/p>\r\n<\/div>\r\n\n<article class=\"violin-complex-pieces\" style=\"font-family: 'Vazirmatn', sans-serif;color: #2E2E2E;line-height: 1.75;max-width: 800px;margin: 40px auto;padding: 30px;background: #FFFFFF;border-radius: 12px;box-shadow: 0 6px 20px rgba(0,0,0,0.05);\">\n<style>\n.violin-complex-pieces h1 { text-align: center; font-size: 2.8rem; color: #1F3A5E; margin-bottom: 24px; }\n.violin-complex-pieces h2 { position: relative; font-size: 1.9rem; color: #243A5E; margin-top: 36px; margin-bottom: 16px; padding-bottom: 6px; }\n.violin-complex-pieces h2::after { content: \"\"; position: absolute; left: 0; bottom: 0; width: 60px; height: 4px; background: linear-gradient(90deg,#4A90E2,#50E3C2); border-radius: 2px; }\n.section-box { background: #F7F9FC; border: 1px solid #E0E4E8; border-radius: 8px; padding: 24px; margin-top: 20px; transition: transform 0.2s, box-shadow 0.2s; }\n.section-box:hover { transform: translateY(-4px); box-shadow: 0 8px 24px rgba(42,77,102,0.1); }\n.section-box p, .section-box ul { margin-bottom: 12px; }\nul { margin-left: 24px; }\nul li { margin-bottom: 8px; }\n.highlight { background: #EAF4FF; color: #1F3A5E; padding: 3px 6px; border-radius: 4px; font-weight: bold; }\n<\/style>\n<h1>\u062a\u062d\u0644\u06cc\u0644 \u06cc\u0627\u062f\u06af\u06cc\u0631\u06cc \u0645\u0627\u0634\u06cc\u0646 \u0627\u062e\u062a\u0644\u0627\u0644 \u0645\u0635\u0631\u0641 \u0645\u0648\u0627\u062f \u0627\u0641\u06cc\u0648\u0646\u06cc \u0628\u0631 \u067e\u0627\u06cc\u0647\u200c\u06cc \u0634\u0628\u06a9\u0647\u200c\u0647\u0627\u06cc \u0627\u06cc\u0646\u062a\u0631\u0627\u06a9\u062a\u0648\u0645\u0650 MOR, DOR, KOR, NOR \u0648 ZOR<\/h1>\n<div class='section-box'>\n<h2>\u0645\u0642\u062f\u0645\u0647 \u0648 \u0627\u0647\u0645\u06cc\u062a \u0645\u0648\u0636\u0648\u0639<\/h2>\n<p>\u0627\u062e\u062a\u0644\u0627\u0644 \u0645\u0635\u0631\u0641 \u0645\u0648\u0627\u062f \u0627\u0641\u06cc\u0648\u0646\u06cc (<highlight>Opioid Use Disorder &#8211; OUD<\/highlight>) \u0628\u0647 \u0639\u0646\u0648\u0627\u0646 \u06cc\u06a9 \u0645\u0639\u0636\u0644 \u062c\u062f\u06cc \u0628\u0647\u062f\u0627\u0634\u062a \u0639\u0645\u0648\u0645\u06cc \u062f\u0631 \u0633\u0637\u062d \u062c\u0647\u0627\u0646\u06cc \u0645\u0637\u0631\u062d \u0627\u0633\u062a \u0648 \u067e\u06cc\u0627\u0645\u062f\u0647\u0627\u06cc \u0627\u062c\u062a\u0645\u0627\u0639\u06cc \u06af\u0633\u062a\u0631\u062f\u0647\u200c\u0627\u06cc \u0631\u0627 \u0628\u0647 \u062f\u0646\u0628\u0627\u0644 \u062f\u0627\u0631\u062f. \u0627\u0641\u0632\u0627\u06cc\u0634 \u0686\u0634\u0645\u06af\u06cc\u0631 \u0648\u0627\u0628\u0633\u062a\u06af\u06cc \u0628\u0647 \u0645\u0648\u0627\u062f \u0627\u0641\u06cc\u0648\u0646\u06cc \u0648 \u0633\u0648\u0621 \u0645\u0635\u0631\u0641 \u0628\u0627\u0644\u0642\u0648\u0647 \u0622\u0646\u200c\u0647\u0627\u060c \u0646\u06cc\u0627\u0632 \u0628\u0647 \u0631\u0648\u06cc\u06a9\u0631\u062f\u0647\u0627\u06cc \u062f\u0631\u0645\u0627\u0646\u06cc \u0645\u0624\u062b\u0631\u062a\u0631 \u0648 \u0627\u06cc\u0645\u0646\u200c\u062a\u0631 \u0631\u0627 \u0628\u0631\u062c\u0633\u062a\u0647 \u0645\u06cc\u200c\u06a9\u0646\u062f. \u062f\u0631 \u062d\u0627\u0644\u06cc \u06a9\u0647 \u062a\u0639\u062f\u0627\u062f\u06cc \u0627\u0632 \u062f\u0627\u0631\u0648\u0647\u0627 \u0628\u0631\u0627\u06cc \u062f\u0631\u0645\u0627\u0646 OUD \u062a\u0623\u06cc\u06cc\u062f \u0634\u062f\u0647\u200c\u0627\u0646\u062f\u060c \u06a9\u0627\u0631\u0627\u06cc\u06cc \u0627\u06cc\u0646 \u062f\u0627\u0631\u0648\u0647\u0627 \u0647\u0646\u0648\u0632 \u062c\u0627\u06cc \u0628\u0647\u0628\u0648\u062f \u062f\u0627\u0631\u062f. \u062f\u0633\u062a\u06cc\u0627\u0628\u06cc \u0628\u0647 \u062f\u0631\u0645\u0627\u0646\u200c\u0647\u0627\u06cc \u0645\u0624\u062b\u0631\u062a\u0631 \u0645\u0633\u062a\u0644\u0632\u0645 \u062f\u0631\u06a9 \u0639\u0645\u06cc\u0642\u200c\u062a\u0631 \u0645\u06a9\u0627\u0646\u06cc\u0633\u0645\u200c\u0647\u0627\u06cc \u0639\u0635\u0628\u06cc-\u0632\u06cc\u0633\u062a\u06cc \u0648\u0627\u0628\u0633\u062a\u06af\u06cc \u0628\u0647 \u0645\u0648\u0627\u062f \u0627\u0641\u06cc\u0648\u0646\u06cc \u0627\u0633\u062a.<\/p>\n<p>\u067e\u0631\u0648\u062a\u0626\u06cc\u0646\u200c\u0647\u0627\u06cc\u06cc \u0646\u0638\u06cc\u0631 \u06af\u06cc\u0631\u0646\u062f\u0647\u200c\u0647\u0627\u06cc \u0627\u0641\u06cc\u0648\u0646\u06cc \u0645\u0648 (MOR)\u060c \u062f\u0644\u062a\u0627 (DOR)\u060c \u06a9\u0627\u067e\u0627 (KOR)\u060c \u0646\u0648\u0633\u06cc\u0633\u067e\u062a\u06cc\u0646 (NOR) \u0648 \u0632\u062a\u0627 (ZOR) \u0627\u0647\u062f\u0627\u0641 \u0645\u0633\u062a\u0642\u06cc\u0645 \u0645\u0648\u0627\u062f \u0627\u0641\u06cc\u0648\u0646\u06cc \u0647\u0633\u062a\u0646\u062f. \u0647\u0631 \u06cc\u06a9 \u0627\u0632 \u0627\u06cc\u0646 \u06af\u06cc\u0631\u0646\u062f\u0647\u200c\u0647\u0627 \u0634\u0628\u06a9\u0647\u200c\u06cc \u0648\u0633\u06cc\u0639\u06cc \u0627\u0632 \u0628\u0631\u0647\u0645\u06a9\u0646\u0634\u200c\u0647\u0627\u06cc \u067e\u0631\u0648\u062a\u0626\u06cc\u0646-\u067e\u0631\u0648\u062a\u0626\u06cc\u0646 (<highlight>Protein-Protein Interaction &#8211; PPI<\/highlight>) \u062f\u0627\u0631\u0646\u062f \u06a9\u0647 \u0631\u0641\u062a\u0627\u0631 \u0645\u062a\u0641\u0627\u0648\u062a\u06cc \u0631\u0627 \u062f\u0631 \u0628\u0631\u0627\u0628\u0631 \u062f\u0631\u0645\u0627\u0646\u200c\u0647\u0627\u06cc \u0645\u062e\u062a\u0644\u0641 \u0646\u0634\u0627\u0646 \u0645\u06cc\u200c\u062f\u0647\u0646\u062f. \u0627\u06cc\u0646 \u067e\u06cc\u0686\u06cc\u062f\u06af\u06cc\u060c \u0641\u0631\u0622\u06cc\u0646\u062f \u062a\u0648\u0633\u0639\u0647\u200c\u06cc \u062f\u0627\u0631\u0648\u0647\u0627\u06cc \u0645\u0624\u062b\u0631 \u0628\u0631\u0627\u06cc \u062f\u0631\u0645\u0627\u0646 \u0627\u0639\u062a\u06cc\u0627\u062f \u0628\u0647 \u0645\u0648\u0627\u062f \u0627\u0641\u06cc\u0648\u0646\u06cc \u0631\u0627 \u062f\u0634\u0648\u0627\u0631\u062a\u0631 \u0645\u06cc\u200c\u06a9\u0646\u062f. \u0645\u0637\u0627\u0644\u0639\u0647\u200c\u06cc \u067e\u06cc\u0634 \u0631\u0648\u060c \u0628\u0627 \u0627\u0631\u0627\u0626\u0647\u200c\u06cc \u06cc\u06a9 \u0628\u0631\u0631\u0633\u06cc \u06cc\u0627\u062f\u06af\u06cc\u0631\u06cc \u0645\u0627\u0634\u06cc\u0646 \u0628\u0631 \u067e\u0627\u06cc\u0647\u200c\u06cc \u0634\u0628\u06a9\u0647\u200c\u0647\u0627\u06cc PPI\u060c \u0628\u0647 \u0627\u06cc\u0646 \u0686\u0627\u0644\u0634 \u0645\u06cc\u200c\u067e\u0631\u062f\u0627\u0632\u062f.<\/p>\n<p>\u0628\u0647 \u0637\u0648\u0631 \u062e\u0644\u0627\u0635\u0647\u060c \u0627\u06cc\u0646 \u0645\u0642\u0627\u0644\u0647 \u0628\u0647 \u0628\u0631\u0631\u0633\u06cc \u06cc\u06a9 \u0631\u0648\u0634 \u0645\u0628\u062a\u0646\u06cc \u0628\u0631 \u06cc\u0627\u062f\u06af\u06cc\u0631\u06cc \u0645\u0627\u0634\u06cc\u0646 \u0645\u06cc \u067e\u0631\u062f\u0627\u0632\u062f \u06a9\u0647 \u0628\u0627 \u0627\u0633\u062a\u0641\u0627\u062f\u0647 \u0627\u0632 \u0627\u0637\u0644\u0627\u0639\u0627\u062a \u0645\u0631\u0628\u0648\u0637 \u0628\u0647 \u0628\u0631\u0647\u0645\u06a9\u0646\u0634 \u0647\u0627\u06cc \u067e\u0631\u0648\u062a\u0626\u06cc\u0646\u06cc \u06af\u06cc\u0631\u0646\u062f\u0647 \u0647\u0627\u06cc \u0645\u0648\u0627\u062f \u0627\u0641\u06cc\u0648\u0646\u06cc\u060c \u0628\u0647 \u062f\u0646\u0628\u0627\u0644 \u0634\u0646\u0627\u0633\u0627\u06cc\u06cc \u062f\u0627\u0631\u0648\u0647\u0627\u06cc \u062c\u062f\u06cc\u062f \u0648 \u06cc\u0627 \u0628\u0627\u0632\u062a\u0639\u0631\u06cc\u0641 \u06a9\u0627\u0631\u0628\u0631\u062f \u062f\u0627\u0631\u0648\u0647\u0627\u06cc \u0645\u0648\u062c\u0648\u062f \u0628\u0631\u0627\u06cc \u062f\u0631\u0645\u0627\u0646 \u0627\u0639\u062a\u06cc\u0627\u062f \u0628\u0647 \u0645\u0648\u0627\u062f \u0627\u0641\u06cc\u0648\u0646\u06cc \u0627\u0633\u062a. \u0627\u0647\u0645\u06cc\u062a \u0627\u06cc\u0646 \u062a\u062d\u0642\u06cc\u0642 \u062f\u0631 \u0627\u0631\u0627\u0626\u0647 \u06cc\u06a9 \u0631\u0648\u06cc\u06a9\u0631\u062f \u0646\u0648\u06cc\u0646 \u0648 \u0628\u0627\u0644\u0642\u0648\u0647 \u0645\u0648\u062b\u0631 \u0628\u0631\u0627\u06cc \u062d\u0644 \u06cc\u06a9 \u0645\u0634\u06a9\u0644 \u0628\u0647\u062f\u0627\u0634\u062a \u0639\u0645\u0648\u0645\u06cc \u0627\u0633\u062a.<\/p>\n<\/p><\/div>\n<div class='section-box'>\n<h2>\u0646\u0648\u06cc\u0633\u0646\u062f\u06af\u0627\u0646 \u0648 \u0632\u0645\u06cc\u0646\u0647 \u062a\u062d\u0642\u06cc\u0642<\/h2>\n<p>\u0627\u06cc\u0646 \u0645\u0637\u0627\u0644\u0639\u0647 \u062a\u0648\u0633\u0637 <highlight>\u0647\u0648\u0646\u06af\u0633\u0648\u0646\u06af \u0641\u0646\u06af\u060c \u0631\u0646\u0627 \u0627\u0644\u0631\u062f\u06a9\u06cc\u060c \u062c\u06cc\u0627\u0646 \u062c\u06cc\u0627\u0646\u06af \u0648 \u06af\u0626\u0648-\u0648\u06cc \u0648\u06cc<\/highlight> \u0627\u0646\u062c\u0627\u0645 \u0634\u062f\u0647 \u0627\u0633\u062a. \u0632\u0645\u06cc\u0646\u0647\u200c\u06cc \u062a\u062d\u0642\u06cc\u0642\u0627\u062a\u06cc \u0627\u06cc\u0646 \u06af\u0631\u0648\u0647\u060c \u0628\u0647 \u0637\u0648\u0631 \u06a9\u0644\u06cc\u060c \u0634\u0627\u0645\u0644 <highlight>\u0628\u06cc\u0648\u0645\u0648\u0644\u06a9\u0648\u0644\u200c\u0647\u0627<\/highlight>\u060c <highlight>\u0634\u0628\u06a9\u0647\u200c\u0647\u0627\u06cc \u0628\u0631\u0647\u0645\u06a9\u0646\u0634 \u067e\u0631\u0648\u062a\u0626\u06cc\u0646-\u067e\u0631\u0648\u062a\u0626\u06cc\u0646<\/highlight>\u060c <highlight>\u06cc\u0627\u062f\u06af\u06cc\u0631\u06cc \u0645\u0627\u0634\u06cc\u0646<\/highlight> \u0648 <highlight>\u062a\u0648\u0633\u0639\u0647 \u062f\u0627\u0631\u0648\u0647\u0627<\/highlight> \u0627\u0633\u062a. \u062a\u062e\u0635\u0635 \u0627\u06cc\u0646 \u0645\u062d\u0642\u0642\u0627\u0646 \u062f\u0631 \u062a\u0631\u06a9\u06cc\u0628 \u0631\u0648\u06cc\u06a9\u0631\u062f\u0647\u0627\u06cc \u0645\u062d\u0627\u0633\u0628\u0627\u062a\u06cc \u0648 \u0632\u06cc\u0633\u062a\u06cc \u0628\u0631\u0627\u06cc \u062d\u0644 \u0645\u0633\u0627\u0626\u0644 \u067e\u06cc\u0686\u06cc\u062f\u0647 \u062f\u0631 \u062d\u0648\u0632\u0647\u200c\u06cc \u0639\u0644\u0648\u0645 \u067e\u0632\u0634\u06a9\u06cc \u0648 \u062f\u0627\u0631\u0648\u06cc\u06cc \u0627\u0633\u062a.<\/p>\n<\/p><\/div>\n<div class='section-box'>\n<h2>\u0686\u06a9\u06cc\u062f\u0647 \u0648 \u062e\u0644\u0627\u0635\u0647 \u0645\u062d\u062a\u0648\u0627<\/h2>\n<p>\u0627\u06cc\u0646 \u067e\u0698\u0648\u0647\u0634\u060c \u0628\u0627 \u0627\u0633\u062a\u0641\u0627\u062f\u0647 \u0627\u0632 \u0645\u062f\u0644\u200c\u0647\u0627\u06cc \u06cc\u0627\u062f\u06af\u06cc\u0631\u06cc \u0645\u0627\u0634\u06cc\u0646 \u06a9\u0647 \u0628\u0631 \u0627\u0633\u0627\u0633 \u0634\u0628\u06a9\u0647\u200c\u0647\u0627\u06cc \u0627\u06cc\u0646\u062a\u0631\u0627\u06a9\u062a\u0648\u0645 \u06af\u06cc\u0631\u0646\u062f\u0647\u200c\u0647\u0627\u06cc \u0627\u0641\u06cc\u0648\u0646\u06cc (MOR, DOR, KOR, NOR \u0648 ZOR) \u0622\u0645\u0648\u0632\u0634 \u062f\u0627\u062f\u0647 \u0634\u062f\u0647\u200c\u0627\u0646\u062f\u060c \u0628\u0647 \u0628\u0631\u0631\u0633\u06cc \u0627\u0645\u06a9\u0627\u0646 \u063a\u0631\u0628\u0627\u0644\u06af\u0631\u06cc \u0648 \u0628\u0627\u0632\u062a\u0639\u0631\u06cc\u0641 \u062f\u0627\u0631\u0648\u0647\u0627\u06cc \u0628\u0627\u0644\u0642\u0648\u0647 \u0628\u0631\u0627\u06cc \u062f\u0631\u0645\u0627\u0646 \u0627\u062e\u062a\u0644\u0627\u0644 \u0645\u0635\u0631\u0641 \u0645\u0648\u0627\u062f \u0627\u0641\u06cc\u0648\u0646\u06cc \u0645\u06cc\u200c\u067e\u0631\u062f\u0627\u0632\u062f. \u0645\u062d\u0642\u0642\u0627\u0646 \u0628\u06cc\u0634 \u0627\u0632 500 \u067e\u0631\u0648\u062a\u0626\u06cc\u0646 \u0645\u0648\u062c\u0648\u062f \u062f\u0631 \u0627\u06cc\u0646 \u067e\u0646\u062c \u0634\u0628\u06a9\u0647 \u06af\u06cc\u0631\u0646\u062f\u0647 \u0631\u0627 \u0628\u0631\u0631\u0633\u06cc \u06a9\u0631\u062f\u0647 \u0648 \u0633\u067e\u0633 74 \u0645\u062c\u0645\u0648\u0639\u0647 \u062f\u0627\u062f\u0647 \u0645\u0647\u0627\u0631\u06a9\u0646\u0646\u062f\u0647 \u0631\u0627 \u062c\u0645\u0639\u200c\u0622\u0648\u0631\u06cc \u06a9\u0631\u062f\u0646\u062f. \u0645\u062f\u0644\u200c\u0647\u0627\u06cc \u06cc\u0627\u062f\u06af\u06cc\u0631\u06cc \u0645\u0627\u0634\u06cc\u0646 \u0628\u0627 \u062a\u0631\u06a9\u06cc\u0628 \u0627\u0644\u06af\u0648\u0631\u06cc\u062a\u0645 \u062f\u0631\u062e\u062a \u062a\u0635\u0645\u06cc\u0645 \u062a\u0642\u0648\u06cc\u062a \u06af\u0631\u0627\u062f\u06cc\u0627\u0646\u06cc (<highlight>Gradient Boosting Decision Tree &#8211; GBDT<\/highlight>) \u0628\u0627 \u062f\u0648 \u0627\u062b\u0631 \u0627\u0646\u06af\u0634\u062a \u0645\u0648\u0644\u06a9\u0648\u0644\u06cc \u067e\u06cc\u0634\u0631\u0641\u062a\u0647 \u0645\u0628\u062a\u0646\u06cc \u0628\u0631 \u067e\u0631\u062f\u0627\u0632\u0634 \u0632\u0628\u0627\u0646 \u0637\u0628\u06cc\u0639\u06cc (<highlight>Natural Language Processing &#8211; NLP<\/highlight>) \u0633\u0627\u062e\u062a\u0647 \u0634\u062f\u0646\u062f.<\/p>\n<p>\u0627\u06cc\u0646 \u0645\u062f\u0644\u200c\u0647\u0627 \u0628\u0631\u0627\u06cc \u0627\u0631\u0632\u06cc\u0627\u0628\u06cc \u0633\u06cc\u0633\u062a\u0645\u0627\u062a\u06cc\u06a9 \u067e\u062a\u0627\u0646\u0633\u06cc\u0644 \u063a\u0631\u0628\u0627\u0644\u06af\u0631\u06cc \u0648 \u0628\u0627\u0632\u062a\u0639\u0631\u06cc\u0641 \u062f\u0627\u0631\u0648 \u0628\u0631\u0627\u06cc \u0686\u0647\u0627\u0631 \u06af\u06cc\u0631\u0646\u062f\u0647 \u0627\u0641\u06cc\u0648\u0646\u06cc \u0628\u0647 \u06a9\u0627\u0631 \u06af\u0631\u0641\u062a\u0647 \u0634\u062f\u0646\u062f. \u0639\u0644\u0627\u0648\u0647 \u0628\u0631 \u0627\u06cc\u0646\u060c \u062e\u0648\u0627\u0635 \u062c\u0630\u0628\u060c \u062a\u0648\u0632\u06cc\u0639\u060c \u0645\u062a\u0627\u0628\u0648\u0644\u06cc\u0633\u0645\u060c \u062f\u0641\u0639 \u0648 \u0633\u0645\u06cc\u062a (<highlight>Absorption, Distribution, Metabolism, Excretion, and Toxicity &#8211; ADMET<\/highlight>) \u0646\u06cc\u0632 \u062f\u0631 \u063a\u0631\u0628\u0627\u0644\u06af\u0631\u06cc \u062f\u0627\u0631\u0648\u0647\u0627\u06cc \u0628\u0627\u0644\u0642\u0648\u0647 \u062f\u0631 \u0646\u0638\u0631 \u06af\u0631\u0641\u062a\u0647 \u0634\u062f\u0646\u062f. \u0646\u062a\u0627\u06cc\u062c \u0627\u06cc\u0646 \u0645\u0637\u0627\u0644\u0639\u0647 \u0646\u0634\u0627\u0646 \u0645\u06cc\u200c\u062f\u0647\u062f \u06a9\u0647 \u0627\u06cc\u0646 \u0631\u0648\u06cc\u06a9\u0631\u062f \u0645\u06cc\u200c\u062a\u0648\u0627\u0646\u062f \u0627\u0628\u0632\u0627\u0631\u06cc \u0627\u0631\u0632\u0634\u0645\u0646\u062f \u0648 \u0627\u0645\u06cc\u062f\u0648\u0627\u0631\u06a9\u0646\u0646\u062f\u0647 \u0628\u0631\u0627\u06cc \u062a\u0648\u0633\u0639\u0647 \u062f\u0627\u0631\u0648\u0647\u0627\u06cc \u0641\u0627\u0631\u0645\u0627\u06a9\u0648\u0644\u0648\u0698\u06cc\u06a9 \u0628\u0631\u0627\u06cc \u062f\u0631\u0645\u0627\u0646 OUD \u0628\u0627\u0634\u062f.<\/p>\n<\/p><\/div>\n<div class='section-box'>\n<h2>\u0631\u0648\u0634\u200c\u0634\u0646\u0627\u0633\u06cc \u062a\u062d\u0642\u06cc\u0642<\/h2>\n<p>\u0631\u0648\u0634\u200c\u0634\u0646\u0627\u0633\u06cc \u0627\u06cc\u0646 \u062a\u062d\u0642\u06cc\u0642 \u0634\u0627\u0645\u0644 \u0686\u0646\u062f\u06cc\u0646 \u0645\u0631\u062d\u0644\u0647 \u06a9\u0644\u06cc\u062f\u06cc \u0627\u0633\u062a:<\/p>\n<ol>\n<li><b>\u0627\u06cc\u062c\u0627\u062f \u0634\u0628\u06a9\u0647\u200c\u0647\u0627\u06cc \u0627\u06cc\u0646\u062a\u0631\u0627\u06a9\u062a\u0648\u0645:<\/b> \u0634\u0628\u06a9\u0647\u200c\u0647\u0627\u06cc PPI \u0628\u0631\u0627\u06cc \u06af\u06cc\u0631\u0646\u062f\u0647\u200c\u0647\u0627\u06cc \u0627\u0641\u06cc\u0648\u0646\u06cc MOR, DOR, KOR, NOR \u0648 ZOR \u0628\u0627 \u0627\u0633\u062a\u0641\u0627\u062f\u0647 \u0627\u0632 \u062f\u0627\u062f\u0647\u200c\u0647\u0627\u06cc \u0645\u0648\u062c\u0648\u062f \u062f\u0631 \u067e\u0627\u06cc\u06af\u0627\u0647\u200c\u0647\u0627\u06cc \u062f\u0627\u062f\u0647 \u067e\u0631\u0648\u062a\u0626\u06cc\u0646\u06cc \u0648 \u0645\u0637\u0627\u0644\u0639\u0627\u062a \u067e\u06cc\u0634\u06cc\u0646 \u0627\u06cc\u062c\u0627\u062f \u0634\u062f\u0646\u062f. \u0627\u06cc\u0646 \u0634\u0628\u06a9\u0647\u200c\u0647\u0627 \u0634\u0627\u0645\u0644 \u067e\u0631\u0648\u062a\u0626\u06cc\u0646\u200c\u0647\u0627\u06cc\u06cc \u0647\u0633\u062a\u0646\u062f \u06a9\u0647 \u0628\u0647 \u0637\u0648\u0631 \u0645\u0633\u062a\u0642\u06cc\u0645 \u06cc\u0627 \u063a\u06cc\u0631\u0645\u0633\u062a\u0642\u06cc\u0645 \u0628\u0627 \u06af\u06cc\u0631\u0646\u062f\u0647\u200c\u0647\u0627\u06cc \u0627\u0641\u06cc\u0648\u0646\u06cc \u062a\u0639\u0627\u0645\u0644 \u062f\u0627\u0631\u0646\u062f.<\/li>\n<li><b>\u062c\u0645\u0639\u200c\u0622\u0648\u0631\u06cc \u062f\u0627\u062f\u0647\u200c\u0647\u0627\u06cc \u0645\u0647\u0627\u0631\u06a9\u0646\u0646\u062f\u0647:<\/b> \u0645\u062c\u0645\u0648\u0639\u0647\u200c\u0627\u06cc \u0627\u0632 74 \u0645\u062c\u0645\u0648\u0639\u0647 \u062f\u0627\u062f\u0647 \u0645\u0647\u0627\u0631\u06a9\u0646\u0646\u062f\u0647 \u0628\u0631\u0627\u06cc \u06af\u06cc\u0631\u0646\u062f\u0647\u200c\u0647\u0627\u06cc \u0627\u0641\u06cc\u0648\u0646\u06cc \u062c\u0645\u0639\u200c\u0622\u0648\u0631\u06cc \u0634\u062f. \u0627\u06cc\u0646 \u062f\u0627\u062f\u0647\u200c\u0647\u0627 \u0634\u0627\u0645\u0644 \u0627\u0637\u0644\u0627\u0639\u0627\u062a \u0645\u0631\u0628\u0648\u0637 \u0628\u0647 \u0645\u0648\u0644\u06a9\u0648\u0644\u200c\u0647\u0627\u06cc\u06cc \u0647\u0633\u062a\u0646\u062f \u06a9\u0647 \u0641\u0639\u0627\u0644\u06cc\u062a \u06af\u06cc\u0631\u0646\u062f\u0647\u200c\u0647\u0627\u06cc \u0627\u0641\u06cc\u0648\u0646\u06cc \u0631\u0627 \u0645\u0647\u0627\u0631 \u0645\u06cc\u200c\u06a9\u0646\u0646\u062f.<\/li>\n<li><b>\u062a\u0648\u0633\u0639\u0647 \u0627\u062b\u0631 \u0627\u0646\u06af\u0634\u062a \u0645\u0648\u0644\u06a9\u0648\u0644\u06cc \u0645\u0628\u062a\u0646\u06cc \u0628\u0631 NLP:<\/b> \u062f\u0648 \u0627\u062b\u0631 \u0627\u0646\u06af\u0634\u062a \u0645\u0648\u0644\u06a9\u0648\u0644\u06cc \u067e\u06cc\u0634\u0631\u0641\u062a\u0647 \u0645\u0628\u062a\u0646\u06cc \u0628\u0631 \u067e\u0631\u062f\u0627\u0632\u0634 \u0632\u0628\u0627\u0646 \u0637\u0628\u06cc\u0639\u06cc \u062a\u0648\u0633\u0639\u0647 \u062f\u0627\u062f\u0647 \u0634\u062f\u0646\u062f. \u0627\u06cc\u0646 \u0627\u062b\u0631 \u0627\u0646\u06af\u0634\u062a\u200c\u0647\u0627\u060c \u0648\u06cc\u0698\u06af\u06cc\u200c\u0647\u0627\u06cc \u0633\u0627\u062e\u062a\u0627\u0631\u06cc \u0648 \u0634\u06cc\u0645\u06cc\u0627\u06cc\u06cc \u0645\u0648\u0644\u06a9\u0648\u0644\u200c\u0647\u0627 \u0631\u0627 \u0628\u0647 \u0635\u0648\u0631\u062a \u06a9\u0645\u06cc \u0646\u0645\u0627\u06cc\u0634 \u0645\u06cc\u200c\u062f\u0647\u0646\u062f \u0648 \u0628\u0647 \u0645\u062f\u0644\u200c\u0647\u0627\u06cc \u06cc\u0627\u062f\u06af\u06cc\u0631\u06cc \u0645\u0627\u0634\u06cc\u0646 \u06a9\u0645\u06a9 \u0645\u06cc\u200c\u06a9\u0646\u0646\u062f \u062a\u0627 \u0627\u0631\u062a\u0628\u0627\u0637 \u0628\u06cc\u0646 \u0633\u0627\u062e\u062a\u0627\u0631 \u0645\u0648\u0644\u06a9\u0648\u0644\u06cc \u0648 \u0641\u0639\u0627\u0644\u06cc\u062a \u0645\u0647\u0627\u0631\u06a9\u0646\u0646\u062f\u06af\u06cc \u0631\u0627 \u062f\u0631\u06a9 \u06a9\u0646\u0646\u062f.<\/li>\n<li><b>\u0633\u0627\u062e\u062a \u0645\u062f\u0644\u200c\u0647\u0627\u06cc \u06cc\u0627\u062f\u06af\u06cc\u0631\u06cc \u0645\u0627\u0634\u06cc\u0646:<\/b> \u0645\u062f\u0644\u200c\u0647\u0627\u06cc \u06cc\u0627\u062f\u06af\u06cc\u0631\u06cc \u0645\u0627\u0634\u06cc\u0646 \u0628\u0627 \u0627\u0633\u062a\u0641\u0627\u062f\u0647 \u0627\u0632 \u0627\u0644\u06af\u0648\u0631\u06cc\u062a\u0645 GBDT \u0648 \u0627\u062b\u0631 \u0627\u0646\u06af\u0634\u062a\u200c\u0647\u0627\u06cc \u0645\u0648\u0644\u06a9\u0648\u0644\u06cc \u0645\u0628\u062a\u0646\u06cc \u0628\u0631 NLP \u0633\u0627\u062e\u062a\u0647 \u0634\u062f\u0646\u062f. GBDT \u06cc\u06a9 \u0627\u0644\u06af\u0648\u0631\u06cc\u062a\u0645 \u0642\u062f\u0631\u062a\u0645\u0646\u062f \u0627\u0633\u062a \u06a9\u0647 \u0645\u06cc\u200c\u062a\u0648\u0627\u0646\u062f \u0631\u0648\u0627\u0628\u0637 \u067e\u06cc\u0686\u06cc\u062f\u0647 \u0628\u06cc\u0646 \u0645\u062a\u063a\u06cc\u0631\u0647\u0627 \u0631\u0627 \u0645\u062f\u0644\u200c\u0633\u0627\u0632\u06cc \u06a9\u0646\u062f.<\/li>\n<li><b>\u0627\u0631\u0632\u06cc\u0627\u0628\u06cc \u0645\u062f\u0644\u200c\u0647\u0627:<\/b> \u0645\u062f\u0644\u200c\u0647\u0627\u06cc \u06cc\u0627\u062f\u06af\u06cc\u0631\u06cc \u0645\u0627\u0634\u06cc\u0646 \u0628\u0631\u0627\u06cc \u0627\u0631\u0632\u06cc\u0627\u0628\u06cc \u067e\u062a\u0627\u0646\u0633\u06cc\u0644 \u063a\u0631\u0628\u0627\u0644\u06af\u0631\u06cc \u0648 \u0628\u0627\u0632\u062a\u0639\u0631\u06cc\u0641 \u062f\u0627\u0631\u0648 \u0628\u0631\u0627\u06cc \u06af\u06cc\u0631\u0646\u062f\u0647\u200c\u0647\u0627\u06cc \u0627\u0641\u06cc\u0648\u0646\u06cc \u0628\u0647 \u06a9\u0627\u0631 \u06af\u0631\u0641\u062a\u0647 \u0634\u062f\u0646\u062f. \u0627\u06cc\u0646 \u0627\u0631\u0632\u06cc\u0627\u0628\u06cc \u0634\u0627\u0645\u0644 \u0628\u0631\u0631\u0633\u06cc \u062f\u0642\u062a\u060c \u062d\u0633\u0627\u0633\u06cc\u062a \u0648 \u0648\u06cc\u0698\u06af\u06cc \u0645\u062f\u0644\u200c\u0647\u0627 \u062f\u0631 \u067e\u06cc\u0634\u200c\u0628\u06cc\u0646\u06cc \u0641\u0639\u0627\u0644\u06cc\u062a \u0645\u0647\u0627\u0631\u06a9\u0646\u0646\u062f\u06af\u06cc \u0645\u0648\u0644\u06a9\u0648\u0644\u200c\u0647\u0627 \u0628\u0648\u062f.<\/li>\n<li><b>\u0627\u0631\u0632\u06cc\u0627\u0628\u06cc \u062e\u0648\u0627\u0635 ADMET:<\/b> \u062e\u0648\u0627\u0635 ADMET \u062f\u0627\u0631\u0648\u0647\u0627\u06cc \u0628\u0627\u0644\u0642\u0648\u0647 \u0646\u06cc\u0632 \u062f\u0631 \u0646\u0638\u0631 \u06af\u0631\u0641\u062a\u0647 \u0634\u062f\u0646\u062f. \u0627\u06cc\u0646 \u062e\u0648\u0627\u0635 \u0634\u0627\u0645\u0644 \u062c\u0630\u0628\u060c \u062a\u0648\u0632\u06cc\u0639\u060c \u0645\u062a\u0627\u0628\u0648\u0644\u06cc\u0633\u0645\u060c \u062f\u0641\u0639 \u0648 \u0633\u0645\u06cc\u062a \u062f\u0627\u0631\u0648\u0647\u0627 \u0647\u0633\u062a\u0646\u062f \u0648 \u0628\u0631\u0627\u06cc \u0627\u0637\u0645\u06cc\u0646\u0627\u0646 \u0627\u0632 \u0627\u06cc\u0645\u0646\u06cc \u0648 \u06a9\u0627\u0631\u0627\u06cc\u06cc \u062f\u0627\u0631\u0648\u0647\u0627 \u0628\u0633\u06cc\u0627\u0631 \u0645\u0647\u0645 \u0647\u0633\u062a\u0646\u062f.<\/li>\n<\/ol>\n<p>\u0628\u0647 \u0639\u0646\u0648\u0627\u0646 \u0645\u062b\u0627\u0644\u060c \u0641\u0631\u0636 \u06a9\u0646\u06cc\u062f \u06cc\u06a9 \u0645\u0648\u0644\u06a9\u0648\u0644 \u062c\u062f\u06cc\u062f \u0628\u0627 \u0633\u0627\u062e\u062a\u0627\u0631\u06cc \u0645\u0646\u062d\u0635\u0631 \u0628\u0647 \u0641\u0631\u062f \u0634\u0646\u0627\u0633\u0627\u06cc\u06cc \u0634\u062f\u0647 \u0627\u0633\u062a. \u0627\u0628\u062a\u062f\u0627 \u0627\u062b\u0631 \u0627\u0646\u06af\u0634\u062a \u0645\u0648\u0644\u06a9\u0648\u0644\u06cc \u0622\u0646 \u0628\u0627 \u0627\u0633\u062a\u0641\u0627\u062f\u0647 \u0627\u0632 \u0631\u0648\u0634\u200c\u0647\u0627\u06cc NLP \u0627\u0633\u062a\u062e\u0631\u0627\u062c \u0645\u06cc\u200c\u0634\u0648\u062f. \u0633\u067e\u0633\u060c \u0627\u06cc\u0646 \u0627\u062b\u0631 \u0627\u0646\u06af\u0634\u062a \u0628\u0647 \u0639\u0646\u0648\u0627\u0646 \u0648\u0631\u0648\u062f\u06cc \u0628\u0647 \u0645\u062f\u0644 GBDT \u062f\u0627\u062f\u0647 \u0645\u06cc\u200c\u0634\u0648\u062f. \u0645\u062f\u0644\u060c \u0628\u0627 \u062a\u0648\u062c\u0647 \u0628\u0647 \u062f\u0627\u062f\u0647\u200c\u0647\u0627\u06cc \u0622\u0645\u0648\u0632\u0634\u06cc \u06a9\u0647 \u0642\u0628\u0644\u0627\u064b \u062f\u06cc\u062f\u0647 \u0627\u0633\u062a\u060c \u067e\u06cc\u0634\u200c\u0628\u06cc\u0646\u06cc \u0645\u06cc\u200c\u06a9\u0646\u062f \u06a9\u0647 \u0622\u06cc\u0627 \u0627\u06cc\u0646 \u0645\u0648\u0644\u06a9\u0648\u0644 \u0627\u062d\u062a\u0645\u0627\u0644\u0627\u064b \u0641\u0639\u0627\u0644\u06cc\u062a \u0645\u0647\u0627\u0631\u06a9\u0646\u0646\u062f\u06af\u06cc \u062f\u0631 \u0628\u0631\u0627\u0628\u0631 \u06af\u06cc\u0631\u0646\u062f\u0647\u200c\u0647\u0627\u06cc \u0627\u0641\u06cc\u0648\u0646\u06cc \u062f\u0627\u0631\u062f \u06cc\u0627 \u062e\u06cc\u0631. \u062f\u0631 \u0646\u0647\u0627\u06cc\u062a\u060c \u062e\u0648\u0627\u0635 ADMET \u0645\u0648\u0644\u06a9\u0648\u0644 \u0646\u06cc\u0632 \u0628\u0631\u0631\u0633\u06cc \u0645\u06cc\u200c\u0634\u0648\u062f \u062a\u0627 \u0627\u0637\u0645\u06cc\u0646\u0627\u0646 \u062d\u0627\u0635\u0644 \u0634\u0648\u062f \u06a9\u0647 \u0627\u06cc\u0646 \u0645\u0648\u0644\u06a9\u0648\u0644 \u0627\u0632 \u0646\u0638\u0631 \u0627\u06cc\u0645\u0646\u06cc \u0648 \u0641\u0627\u0631\u0645\u0627\u06a9\u0648\u06a9\u06cc\u0646\u062a\u06cc\u06a9 \u0645\u0646\u0627\u0633\u0628 \u0627\u0633\u062a.<\/p>\n<\/p><\/div>\n<div class='section-box'>\n<h2>\u06cc\u0627\u0641\u062a\u0647\u200c\u0647\u0627\u06cc \u06a9\u0644\u06cc\u062f\u06cc<\/h2>\n<p>\u06cc\u0627\u0641\u062a\u0647\u200c\u0647\u0627\u06cc \u06a9\u0644\u06cc\u062f\u06cc \u0627\u06cc\u0646 \u062a\u062d\u0642\u06cc\u0642 \u0639\u0628\u0627\u0631\u062a\u0646\u062f \u0627\u0632:<\/p>\n<ul>\n<li>\u0645\u062f\u0644\u200c\u0647\u0627\u06cc \u06cc\u0627\u062f\u06af\u06cc\u0631\u06cc \u0645\u0627\u0634\u06cc\u0646 \u0645\u0628\u062a\u0646\u06cc \u0628\u0631 \u0634\u0628\u06a9\u0647\u200c\u0647\u0627\u06cc \u0627\u06cc\u0646\u062a\u0631\u0627\u06a9\u062a\u0648\u0645 \u06af\u06cc\u0631\u0646\u062f\u0647\u200c\u0647\u0627\u06cc \u0627\u0641\u06cc\u0648\u0646\u06cc\u060c \u0642\u0627\u062f\u0631 \u0628\u0647 \u067e\u06cc\u0634\u200c\u0628\u06cc\u0646\u06cc \u062f\u0642\u06cc\u0642 \u0641\u0639\u0627\u0644\u06cc\u062a \u0645\u0647\u0627\u0631\u06a9\u0646\u0646\u062f\u06af\u06cc \u0645\u0648\u0644\u06a9\u0648\u0644\u200c\u0647\u0627 \u062f\u0631 \u0628\u0631\u0627\u0628\u0631 \u0627\u06cc\u0646 \u06af\u06cc\u0631\u0646\u062f\u0647\u200c\u0647\u0627 \u0647\u0633\u062a\u0646\u062f.<\/li>\n<li>\u0627\u062b\u0631 \u0627\u0646\u06af\u0634\u062a\u200c\u0647\u0627\u06cc \u0645\u0648\u0644\u06a9\u0648\u0644\u06cc \u0645\u0628\u062a\u0646\u06cc \u0628\u0631 NLP\u060c \u0627\u0637\u0644\u0627\u0639\u0627\u062a \u0627\u0631\u0632\u0634\u0645\u0646\u062f\u06cc \u0631\u0627 \u062f\u0631 \u0645\u0648\u0631\u062f \u0633\u0627\u062e\u062a\u0627\u0631 \u0648 \u0641\u0639\u0627\u0644\u06cc\u062a \u0645\u0648\u0644\u06a9\u0648\u0644\u200c\u0647\u0627 \u0627\u0631\u0627\u0626\u0647 \u0645\u06cc\u200c\u062f\u0647\u0646\u062f \u0648 \u0628\u0647 \u0628\u0647\u0628\u0648\u062f \u0639\u0645\u0644\u06a9\u0631\u062f \u0645\u062f\u0644\u200c\u0647\u0627\u06cc \u06cc\u0627\u062f\u06af\u06cc\u0631\u06cc \u0645\u0627\u0634\u06cc\u0646 \u06a9\u0645\u06a9 \u0645\u06cc\u200c\u06a9\u0646\u0646\u062f.<\/li>\n<li>\u0627\u06cc\u0646 \u0631\u0648\u06cc\u06a9\u0631\u062f \u0645\u06cc\u200c\u062a\u0648\u0627\u0646\u062f \u0628\u0631\u0627\u06cc \u0634\u0646\u0627\u0633\u0627\u06cc\u06cc \u062f\u0627\u0631\u0648\u0647\u0627\u06cc \u062c\u062f\u06cc\u062f \u0648 \u06cc\u0627 \u0628\u0627\u0632\u062a\u0639\u0631\u06cc\u0641 \u06a9\u0627\u0631\u0628\u0631\u062f \u062f\u0627\u0631\u0648\u0647\u0627\u06cc \u0645\u0648\u062c\u0648\u062f \u0628\u0631\u0627\u06cc \u062f\u0631\u0645\u0627\u0646 OUD \u0645\u0648\u0631\u062f \u0627\u0633\u062a\u0641\u0627\u062f\u0647 \u0642\u0631\u0627\u0631 \u06af\u06cc\u0631\u062f.<\/li>\n<li>\u0627\u0631\u0632\u06cc\u0627\u0628\u06cc \u062e\u0648\u0627\u0635 ADMET \u062f\u0631 \u063a\u0631\u0628\u0627\u0644\u06af\u0631\u06cc \u062f\u0627\u0631\u0648\u0647\u0627\u06cc \u0628\u0627\u0644\u0642\u0648\u0647\u060c \u0646\u0642\u0634 \u0645\u0647\u0645\u06cc \u062f\u0631 \u0634\u0646\u0627\u0633\u0627\u06cc\u06cc \u062f\u0627\u0631\u0648\u0647\u0627\u06cc \u0627\u06cc\u0645\u0646 \u0648 \u0645\u0624\u062b\u0631 \u062f\u0627\u0631\u062f.<\/li>\n<\/ul>\n<p>\u0628\u0647 \u0637\u0648\u0631 \u062e\u0627\u0635\u060c \u0645\u062f\u0644\u200c\u0647\u0627 \u062f\u0631 \u0634\u0646\u0627\u0633\u0627\u06cc\u06cc \u0645\u0647\u0627\u0631\u06a9\u0646\u0646\u062f\u0647\u200c\u0647\u0627\u06cc \u0627\u062d\u062a\u0645\u0627\u0644\u06cc \u0628\u0631\u0627\u06cc \u06af\u06cc\u0631\u0646\u062f\u0647\u200c\u0647\u0627\u06cc DOR \u0648 KOR \u0639\u0645\u0644\u06a9\u0631\u062f \u0628\u0647\u062a\u0631\u06cc \u062f\u0627\u0634\u062a\u0646\u062f. \u0627\u06cc\u0646 \u0645\u0648\u0636\u0648\u0639 \u0646\u0634\u0627\u0646 \u0645\u06cc\u200c\u062f\u0647\u062f \u06a9\u0647 \u0631\u0648\u06cc\u06a9\u0631\u062f \u067e\u06cc\u0634\u0646\u0647\u0627\u062f\u06cc \u0645\u06cc\u200c\u062a\u0648\u0627\u0646\u062f \u0628\u0647 \u0648\u06cc\u0698\u0647 \u062f\u0631 \u062a\u0648\u0633\u0639\u0647 \u062f\u0631\u0645\u0627\u0646\u200c\u0647\u0627\u06cc \u0647\u062f\u0641\u0645\u0646\u062f \u0628\u0631\u0627\u06cc \u06a9\u0627\u0647\u0634 \u0639\u0644\u0627\u0626\u0645 \u062a\u0631\u06a9 \u0627\u0639\u062a\u06cc\u0627\u062f \u0648 \u062c\u0644\u0648\u06af\u06cc\u0631\u06cc \u0627\u0632 \u0639\u0648\u062f \u0628\u06cc\u0645\u0627\u0631\u06cc \u0645\u0641\u06cc\u062f \u0628\u0627\u0634\u062f.<\/p>\n<\/p><\/div>\n<div class='section-box'>\n<h2>\u06a9\u0627\u0631\u0628\u0631\u062f\u0647\u0627 \u0648 \u062f\u0633\u062a\u0627\u0648\u0631\u062f\u0647\u0627<\/h2>\n<p>\u0627\u06cc\u0646 \u062a\u062d\u0642\u06cc\u0642 \u062f\u0627\u0631\u0627\u06cc \u06a9\u0627\u0631\u0628\u0631\u062f\u0647\u0627\u06cc \u0645\u062a\u0639\u062f\u062f\u06cc \u0627\u0633\u062a:<\/p>\n<ul>\n<li><b>\u0634\u0646\u0627\u0633\u0627\u06cc\u06cc \u062f\u0627\u0631\u0648\u0647\u0627\u06cc \u062c\u062f\u06cc\u062f \u0628\u0631\u0627\u06cc \u062f\u0631\u0645\u0627\u0646 OUD:<\/b> \u0627\u06cc\u0646 \u0631\u0648\u06cc\u06a9\u0631\u062f \u0645\u06cc\u200c\u062a\u0648\u0627\u0646\u062f \u0628\u0647 \u0645\u062d\u0642\u0642\u0627\u0646 \u06a9\u0645\u06a9 \u06a9\u0646\u062f \u062a\u0627 \u0645\u0648\u0644\u06a9\u0648\u0644\u200c\u0647\u0627\u06cc \u062c\u062f\u06cc\u062f\u06cc \u0631\u0627 \u0634\u0646\u0627\u0633\u0627\u06cc\u06cc \u06a9\u0646\u0646\u062f \u06a9\u0647 \u0641\u0639\u0627\u0644\u06cc\u062a \u0645\u0647\u0627\u0631\u06a9\u0646\u0646\u062f\u06af\u06cc \u062f\u0631 \u0628\u0631\u0627\u0628\u0631 \u06af\u06cc\u0631\u0646\u062f\u0647\u200c\u0647\u0627\u06cc \u0627\u0641\u06cc\u0648\u0646\u06cc \u062f\u0627\u0631\u0646\u062f \u0648 \u0645\u06cc\u200c\u062a\u0648\u0627\u0646\u0646\u062f \u0628\u0647 \u0639\u0646\u0648\u0627\u0646 \u062f\u0627\u0631\u0648\u0647\u0627\u06cc \u0628\u0627\u0644\u0642\u0648\u0647 \u0628\u0631\u0627\u06cc \u062f\u0631\u0645\u0627\u0646 OUD \u062a\u0648\u0633\u0639\u0647 \u06cc\u0627\u0628\u0646\u062f.<\/li>\n<li><b>\u0628\u0627\u0632\u062a\u0639\u0631\u06cc\u0641 \u06a9\u0627\u0631\u0628\u0631\u062f \u062f\u0627\u0631\u0648\u0647\u0627\u06cc \u0645\u0648\u062c\u0648\u062f:<\/b> \u0627\u06cc\u0646 \u0631\u0648\u06cc\u06a9\u0631\u062f \u0645\u06cc\u200c\u062a\u0648\u0627\u0646\u062f \u0628\u0647 \u0634\u0646\u0627\u0633\u0627\u06cc\u06cc \u062f\u0627\u0631\u0648\u0647\u0627\u06cc \u0645\u0648\u062c\u0648\u062f\u06cc \u06a9\u0645\u06a9 \u06a9\u0646\u062f \u06a9\u0647 \u0645\u06cc\u200c\u062a\u0648\u0627\u0646\u0646\u062f \u0628\u0631\u0627\u06cc \u062f\u0631\u0645\u0627\u0646 OUD \u0645\u0648\u0631\u062f \u0627\u0633\u062a\u0641\u0627\u062f\u0647 \u0642\u0631\u0627\u0631 \u06af\u06cc\u0631\u0646\u062f. \u0627\u06cc\u0646 \u0627\u0645\u0631 \u0645\u06cc\u200c\u062a\u0648\u0627\u0646\u062f \u0641\u0631\u0622\u06cc\u0646\u062f \u062a\u0648\u0633\u0639\u0647 \u062f\u0627\u0631\u0648 \u0631\u0627 \u062a\u0633\u0631\u06cc\u0639 \u06a9\u0646\u062f \u0648 \u0647\u0632\u06cc\u0646\u0647\u200c\u0647\u0627 \u0631\u0627 \u06a9\u0627\u0647\u0634 \u062f\u0647\u062f.<\/li>\n<li><b>\u062a\u0648\u0633\u0639\u0647 \u062f\u0631\u0645\u0627\u0646\u200c\u0647\u0627\u06cc \u0647\u062f\u0641\u0645\u0646\u062f:<\/b> \u0627\u06cc\u0646 \u0631\u0648\u06cc\u06a9\u0631\u062f \u0645\u06cc\u200c\u062a\u0648\u0627\u0646\u062f \u0628\u0647 \u062a\u0648\u0633\u0639\u0647 \u062f\u0631\u0645\u0627\u0646\u200c\u0647\u0627\u06cc \u0647\u062f\u0641\u0645\u0646\u062f \u0628\u0631\u0627\u06cc OUD \u06a9\u0645\u06a9 \u06a9\u0646\u062f. \u0628\u0627 \u062f\u0631\u06a9 \u0628\u0647\u062a\u0631 \u0645\u06a9\u0627\u0646\u06cc\u0633\u0645\u200c\u0647\u0627\u06cc \u0639\u0635\u0628\u06cc-\u0632\u06cc\u0633\u062a\u06cc \u0648\u0627\u0628\u0633\u062a\u06af\u06cc \u0628\u0647 \u0645\u0648\u0627\u062f \u0627\u0641\u06cc\u0648\u0646\u06cc\u060c \u0645\u06cc\u200c\u062a\u0648\u0627\u0646 \u062f\u0627\u0631\u0648\u0647\u0627\u06cc\u06cc \u0631\u0627 \u0637\u0631\u0627\u062d\u06cc \u06a9\u0631\u062f \u06a9\u0647 \u0628\u0647 \u0637\u0648\u0631 \u062e\u0627\u0635 \u0627\u06cc\u0646 \u0645\u06a9\u0627\u0646\u06cc\u0633\u0645\u200c\u0647\u0627 \u0631\u0627 \u0647\u062f\u0641 \u0642\u0631\u0627\u0631 \u0645\u06cc\u200c\u062f\u0647\u0646\u062f.<\/li>\n<li><b>\u06a9\u0627\u0647\u0634 \u0647\u0632\u06cc\u0646\u0647\u200c\u0647\u0627 \u0648 \u0632\u0645\u0627\u0646 \u062a\u0648\u0633\u0639\u0647 \u062f\u0627\u0631\u0648:<\/b> \u0627\u0633\u062a\u0641\u0627\u062f\u0647 \u0627\u0632 \u0631\u0648\u0634\u200c\u0647\u0627\u06cc \u06cc\u0627\u062f\u06af\u06cc\u0631\u06cc \u0645\u0627\u0634\u06cc\u0646 \u0648 \u0645\u062f\u0644\u200c\u0633\u0627\u0632\u06cc \u0645\u062d\u0627\u0633\u0628\u0627\u062a\u06cc \u0645\u06cc\u200c\u062a\u0648\u0627\u0646\u062f \u0647\u0632\u06cc\u0646\u0647\u200c\u0647\u0627 \u0648 \u0632\u0645\u0627\u0646 \u0645\u0648\u0631\u062f \u0646\u06cc\u0627\u0632 \u0628\u0631\u0627\u06cc \u062a\u0648\u0633\u0639\u0647 \u062f\u0627\u0631\u0648\u0647\u0627\u06cc \u062c\u062f\u06cc\u062f \u0631\u0627 \u0628\u0647 \u0637\u0648\u0631 \u0642\u0627\u0628\u0644 \u062a\u0648\u062c\u0647\u06cc \u06a9\u0627\u0647\u0634 \u062f\u0647\u062f.<\/li>\n<\/ul>\n<p>\u06cc\u06a9\u06cc \u0627\u0632 \u062f\u0633\u062a\u0627\u0648\u0631\u062f\u0647\u0627\u06cc \u0645\u0647\u0645 \u0627\u06cc\u0646 \u062a\u062d\u0642\u06cc\u0642\u060c \u0627\u0631\u0627\u0626\u0647 \u06cc\u06a9 \u0686\u0627\u0631\u0686\u0648\u0628 \u0645\u062d\u0627\u0633\u0628\u0627\u062a\u06cc \u0627\u0633\u062a \u06a9\u0647 \u0645\u06cc\u200c\u062a\u0648\u0627\u0646\u062f \u0628\u0647 \u0637\u0648\u0631 \u06af\u0633\u062a\u0631\u062f\u0647 \u0628\u0631\u0627\u06cc \u063a\u0631\u0628\u0627\u0644\u06af\u0631\u06cc \u062f\u0627\u0631\u0648\u0647\u0627 \u0648 \u0634\u0646\u0627\u0633\u0627\u06cc\u06cc \u062f\u0631\u0645\u0627\u0646\u200c\u0647\u0627\u06cc \u0628\u0627\u0644\u0642\u0648\u0647 \u0628\u0631\u0627\u06cc \u0633\u0627\u06cc\u0631 \u0627\u062e\u062a\u0644\u0627\u0644\u0627\u062a \u0639\u0635\u0628\u06cc-\u0631\u0648\u0627\u0646\u06cc \u0646\u06cc\u0632 \u0645\u0648\u0631\u062f \u0627\u0633\u062a\u0641\u0627\u062f\u0647 \u0642\u0631\u0627\u0631 \u06af\u06cc\u0631\u062f.<\/p>\n<\/p><\/div>\n<div class='section-box'>\n<h2>\u0646\u062a\u06cc\u062c\u0647\u200c\u06af\u06cc\u0631\u06cc<\/h2>\n<p>\u0627\u06cc\u0646 \u0645\u0637\u0627\u0644\u0639\u0647 \u0646\u0634\u0627\u0646 \u0645\u06cc\u200c\u062f\u0647\u062f \u06a9\u0647 \u0627\u0633\u062a\u0641\u0627\u062f\u0647 \u0627\u0632 \u0645\u062f\u0644\u200c\u0647\u0627\u06cc \u06cc\u0627\u062f\u06af\u06cc\u0631\u06cc \u0645\u0627\u0634\u06cc\u0646 \u0645\u0628\u062a\u0646\u06cc \u0628\u0631 \u0634\u0628\u06a9\u0647\u200c\u0647\u0627\u06cc \u0627\u06cc\u0646\u062a\u0631\u0627\u06a9\u062a\u0648\u0645 \u06af\u06cc\u0631\u0646\u062f\u0647\u200c\u0647\u0627\u06cc \u0627\u0641\u06cc\u0648\u0646\u06cc\u060c \u0631\u0648\u06cc\u06a9\u0631\u062f\u06cc \u0627\u0645\u06cc\u062f\u0648\u0627\u0631\u06a9\u0646\u0646\u062f\u0647 \u0628\u0631\u0627\u06cc \u0634\u0646\u0627\u0633\u0627\u06cc\u06cc \u062f\u0627\u0631\u0648\u0647\u0627\u06cc \u062c\u062f\u06cc\u062f \u0648 \u06cc\u0627 \u0628\u0627\u0632\u062a\u0639\u0631\u06cc\u0641 \u06a9\u0627\u0631\u0628\u0631\u062f \u062f\u0627\u0631\u0648\u0647\u0627\u06cc \u0645\u0648\u062c\u0648\u062f \u0628\u0631\u0627\u06cc \u062f\u0631\u0645\u0627\u0646 \u0627\u062e\u062a\u0644\u0627\u0644 \u0645\u0635\u0631\u0641 \u0645\u0648\u0627\u062f \u0627\u0641\u06cc\u0648\u0646\u06cc \u0627\u0633\u062a. \u0627\u06cc\u0646 \u0631\u0648\u06cc\u06a9\u0631\u062f \u0645\u06cc\u200c\u062a\u0648\u0627\u0646\u062f \u0628\u0647 \u062a\u0648\u0633\u0639\u0647 \u062f\u0631\u0645\u0627\u0646\u200c\u0647\u0627\u06cc \u0645\u0624\u062b\u0631\u062a\u0631 \u0648 \u0627\u06cc\u0645\u0646\u200c\u062a\u0631 \u0628\u0631\u0627\u06cc \u0627\u06cc\u0646 \u0645\u0639\u0636\u0644 \u0628\u0647\u062f\u0627\u0634\u062a \u0639\u0645\u0648\u0645\u06cc \u06a9\u0645\u06a9 \u06a9\u0646\u062f. \u0628\u0627 \u0627\u06cc\u0646 \u062d\u0627\u0644\u060c \u0644\u0627\u0632\u0645 \u0627\u0633\u062a \u062a\u0648\u062c\u0647 \u062f\u0627\u0634\u062a \u06a9\u0647 \u0646\u062a\u0627\u06cc\u062c \u0627\u06cc\u0646 \u0645\u0637\u0627\u0644\u0639\u0647 \u0628\u0631 \u0627\u0633\u0627\u0633 \u0645\u062f\u0644\u200c\u0633\u0627\u0632\u06cc \u0645\u062d\u0627\u0633\u0628\u0627\u062a\u06cc \u0627\u0633\u062a \u0648 \u0628\u0631\u0627\u06cc \u062a\u0627\u06cc\u06cc\u062f \u0646\u062a\u0627\u06cc\u062c \u0648 \u0627\u062b\u0628\u0627\u062a \u06a9\u0627\u0631\u0627\u06cc\u06cc \u062f\u0627\u0631\u0648\u0647\u0627\u06cc \u0634\u0646\u0627\u0633\u0627\u06cc\u06cc \u0634\u062f\u0647\u060c \u0646\u06cc\u0627\u0632 \u0628\u0647 \u0627\u0646\u062c\u0627\u0645 \u0622\u0632\u0645\u0627\u06cc\u0634\u200c\u0647\u0627\u06cc in vitro \u0648 in vivo \u0648 \u0645\u0637\u0627\u0644\u0639\u0627\u062a \u0628\u0627\u0644\u06cc\u0646\u06cc \u0628\u06cc\u0634\u062a\u0631\u06cc \u0627\u0633\u062a. \u0628\u0627 \u0627\u06cc\u0646 \u0648\u062c\u0648\u062f\u060c \u0627\u06cc\u0646 \u062a\u062d\u0642\u06cc\u0642 \u06af\u0627\u0645\u06cc \u0645\u0647\u0645 \u062f\u0631 \u062c\u0647\u062a \u062a\u0648\u0633\u0639\u0647 \u0631\u0648\u06cc\u06a9\u0631\u062f\u0647\u0627\u06cc \u062f\u0631\u0645\u0627\u0646\u06cc \u0646\u0648\u06cc\u0646 \u0628\u0631\u0627\u06cc OUD \u0645\u062d\u0633\u0648\u0628 \u0645\u06cc\u200c\u0634\u0648\u062f.<\/p>\n<\/p><\/div>\n<\/article>\n","protected":false},"excerpt":{"rendered":"<p>\ud83d\udcda \u0645\u0642\u0627\u0644\u0647 \u0639\u0644\u0645\u06cc \u0639\u0646\u0648\u0627\u0646 \u0641\u0627\u0631\u0633\u06cc \u0645\u0642\u0627\u0644\u0647 \u062a\u062d\u0644\u06cc\u0644 \u06cc\u0627\u062f\u06af\u06cc\u0631\u06cc \u0645\u0627\u0634\u06cc\u0646 \u0627\u062e\u062a\u0644\u0627\u0644 \u0645\u0635\u0631\u0641 \u0645\u0648\u0627\u062f \u0627\u0641\u06cc\u0648\u0646\u06cc \u0628\u0631 \u067e\u0627\u06cc\u0647\u200c\u06cc \u0634\u0628\u06a9\u0647\u200c\u0647\u0627\u06cc \u0627\u06cc\u0646\u062a\u0631\u0627\u06a9\u062a\u0648\u0645\u0650 MOR, DOR, KOR, 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